DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp64D and CG14535

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	123/504 - (24%)
Similarity:	197/504 - (39%)	Gaps:	120/504 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IENVRVVVRTRPMDKNELSAGA-LSAISVDKINRAITVMKPNATANEP------------PKTYY 69
            :..|:|::|....|:|  |.|. ...:::||..|.:|:..|......|            ||.:.
  Fly    42 VGKVKVMLRVADRDRN--SGGTEPDFMALDKKKRQVTLTDPRTACPPPQAAQERAPMVAAPKMFA 104

  Fly    70 FDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYT----MSGNPDSPQTK--- 127
            |||:|.|...|.|:.......::..||||.:|.:||.|...||:..|    :.|...|....
  Fly   105 FDNLFTGEDKQSDVCASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLGELGGGSGSGSASGSG 169

  Fly   128 -----GIIPNAFAHIFGHI--AKAKENQKFLVRVSYMEIYNEEVRDLLGKD--VGKSLEVKERPD 183
                 |..|.|.|.::..|  .:.|...:|.||||.:.: :....|.|.:|  :..:.|..:.|
  Fly   170 VACSLGAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGV-SATKPDALSQDLLISHAAESDDSP- 232

  Fly   184 IGVFVKD--LSGYVVHNADDLENI-----MRLGNKNRAVGATKMNQESS----RSHAIFSITVER 237
             |::::|  |.|.....|...|..     ..|..:.::.|:|.......    .|..||::.|.:
  Fly   233 -GIYLRDDFLGGPTELRAPTAERAALFLDSALAGRLKSSGSTASGSSGCAAPLESALIFTLHVYQ 296

  Fly   238 SELG-EGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTH 301
            ..|. :|.|...| .:|.::||.|...::.              .|.||.:||::.|::.|: .|
  Fly   297 YSLSRKGGVAGGR-SRLHIIDLGGCANRNG--------------GLPLSGIGNILLAILSGQ-RH 345

  Fly   302 IPYRNSKLTRLLQDSLGGNSKTVMC-----ATISPADSNYMETISTLRYASRAKNIQNRMHINEE 361
            .|:::..||.||:|.|.    .:.|     |.:.| :.:|.:.:||::.|||...::.|.|....
  Fly   346 PPHKDHPLTPLLKDCLA----PITCHVAIVAHVRP-EQSYQDALSTIQIASRIHRLRRRKHRVPM 405

  Fly   362 PKDALLRHFQEEIARLRKQLEEG-------DSLEEEPPSSEEEEDTA------DD--ELEAPLEI 411
            |              |...|.:|       .....:|.|||...||.      ||  :.|.| .:
  Fly   406 P--------------LAVGLAQGLGGNGSSAGSGADPSSSEISADTVIYMGPNDDATDGEHP-PV 455

  Fly   412 ELESSTI-------------QAVEKKPKKKREKT-----DAEKEELAKR 442
            .|.|.|.             ..:||.|.|....:     .|...|.||:
  Fly   456 YLPSLTAGDNRGVMSKALKGSGLEKPPSKSASNSPMMMKKAMAAEKAKK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	96/378 (25%)
		Kinesin	26..352	CDD:278646	94/371 (25%)
		RILP-like	<437..556	CDD:304877	3/6 (50%)
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	96/375 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000