DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Klp10A

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	167/564 - (29%)
Similarity:	246/564 - (43%)	Gaps:	121/564 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPQEEANAG-TTAQLDDEIEN-----------------VRVVVRTRPMDKNELSAGALSAISVDK 47
            |.|:..|.. .|||:..|.::                 :.|.||.||:.:.|::...:..|||.:
  Fly   241 MNQDPGNPNWETAQMIREYQSTLEFVPLLDGQAVDDHQITVCVRKRPISRKEVNRKEIDVISVPR 305

  Fly    48 INRAITVMKPNATAN-----EPPKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYG 107
            .:..| |.:|.:..:     |..| :.||..|:...:...:|..||:|:|..:.||...|..|||
  Fly   306 KDMLI-VHEPRSKVDLTKFLENHK-FRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYG 368

  Fly   108 QTGTGKTYTMSG--NPDSPQTK-GIIPNAFAHIFGHIAKAK-ENQKFLVRVSYMEIYNEEVRDLL 168
            |||:|||:||.|  |......| ||...|...:|..:...: .....:|..|:.|||:.:|.|||
  Fly   369 QTGSGKTHTMGGEFNGKVQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLL 433

  Fly   169 GKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSI 233
            ...  :.|.|.|.....|.|..|:..||...:::..:::.||..|..|.|..|..||||||:|.|
  Fly   434 SDK--QKLRVLEDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQI 496

  Fly   234 TVERSELGEGDVQ-HVRMGKLQLVDLAGSERQSKTQASGQRLK-EATKINLSLSVLGNVISALVD 296
            .:.    .:|..: |   ||...:||||:||...|.::.::.: |..:||.||..|...|.||
  Fly   497 VLR----PQGSTKIH---GKFSFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRAL-- 552

  Fly   297 GK-STHIPYRNSKLTRLLQDS-LGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHIN 359
            || |.|:|:|.||||::|:|| :|..|||.|.|.|||..|:...|::|||||.|.
  Fly   553 GKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRV---------- 607

  Fly   360 EEPKDALLRHFQEEIARLRKQLEEGDSLEEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKK 424
                               |:|...|.:|..|....|           |:||
  Fly   608 -------------------KELVVKDIVEVCPGGDTE-----------PIEI------------- 629

  Fly   425 PKKKREKTDAEKEELAKRKNEHQKEI---EHAKTEQETLRNKLVS-LEGKILVGGENLLEK---A 482
                   ||.|:||.....:.|..::   .||...|...:....| ..|.::....|...|   |
  Fly   630 -------TDDEEEEELNMVHPHSHQLHPNSHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNA 687

  Fly   483 QTQELLLEQSIAELEQHEKSEEALKQ-----TLQQKATERIDIE 521
            ...:|.:   ::.|.:||.|:|.:.|     .|||  ||.:.:|
  Fly   688 GNMDLAM---LSSLSEHEMSDELIVQHQAIDDLQQ--TEEMVVE 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	124/362 (34%)
		Kinesin	26..352	CDD:278646	122/338 (36%)
		RILP-like	<437..556	CDD:304877	24/97 (25%)
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	124/371 (33%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	122/366 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437765
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940