DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Kif6

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_796026.2	Gene:	Kif6 / 319991	MGIID:	1098238	Length:	802	Species:	Mus musculus

Alignment Length:	722	Identity:	211/722 - (29%)
Similarity:	338/722 - (46%)	Gaps:	153/722 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATA----NEPPKTY--YFDNVFDGG 77
            :.:::..|.:|..:.: ..|..|....:|:..::.::.|...|    |...::|  .|..:||..
Mouse     4 QTIQIFARVKPTVRKQ-QQGIYSIDEDEKLTHSLEIVLPRDLADGFVNNKRESYKFKFQRIFDQE 67

  Fly    78 SNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIA 142
            :.|..::...|:|:.:..|.||||||.||||||:|||:|::|..:....:||||...::||..:.
Mouse    68 AKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQ 132

  Fly   143 KAKENQKFLVRVSYMEIYNEEVRDLLG--------KDVGKSLEVKERPDIGVFVKDLSGYVVHNA 199
            | ..::.:...:||:|||||...|||.        :|:.| :.:.|.||..:.:|:||.:.....
Mouse   133 K-DSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPK-VTILEDPDQNIHLKNLSLHQATTE 195

  Fly   200 DDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQ 264
            ::..|::.||:.||.:..|.|||.|:|||.||::.:...|.|...|:|   .||.|||||||||.
Mouse   196 EEALNLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSATVRH---AKLHLVDLAGSERV 257

  Fly   265 SKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATI 329
            |||...|..|.||..|||||..|..||.||.:...||||||||.:|.:|:||||||..|.|.||:
Mouse   258 SKTGVGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIPYRNSMMTSVLRDSLGGNCMTTMIATL 322

  Fly   330 SPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEEPPSS 394
            |....|..|:|||.|:|.|...|:|...:|||....|:      |.||:|::|:   |:.|...:
Mouse   323 SLEKRNIDESISTCRFAQRVALIKNEAILNEEIDPRLM------IVRLQKEIED---LKAELAMA 378

  Fly   395 EEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTDAEKEEL------AKRKNEHQKEIEHA 453
            ..|:.| :...||.| ::||......:|.:..:.|.:..|:..::      .|:....:|.:|:.
Mouse   379 TGEQRT-EALTEAEL-LQLEKLIASYLEDQDPESRLEVGADMRKIHHCFHHFKKLLNDKKTLENT 441

  Fly   454 KTE-------QETLRN----KLVSL------EGKILVGGENLL--EKAQTQELLLEQSIAELEQ- 498
            .:.       ||.||:    ||:.|      |..|||   |:|  ||.:||:.|...|:.:.:.
Mouse   442 VSSESTRQACQEPLRDEEYTKLLGLLKQRDNEINILV---NMLKKEKKKTQDALQNSSLEKSDTR 503

  Fly   499 ---------------------------------------HEKS----------EEAL-------- 506
                                                   |:|:          :||.
Mouse   504 PPQNSPFIAGSPAVPRTPFSSAPSHTQDLSICRHRSSLLHKKTGMREEMSLGRQEAFEIFKRDHA 568

  Fly   507 --------KQTLQQKATER----IDIEERYSTLQDASTGITKKIHRVMQMLMG-----VKSELAD 554
                    ||.|:|:.:|.    ..|.|..|.:......|.::  .:.|:.:|     |.:...|
Mouse   569 DSVTIEDNKQVLKQRFSEAKALGESINEARSKIGQLKDAINQR--HLQQVALGISENTVPASTPD 631

  Fly   555 QQQEHQR----EKEGIYE----NIRSLSRELALCELVLNS---YVPKEYQSMINQYTHWNEDIGE 608
            .|:|..|    |::|.|:    ::::|..|:...:|:::.   .:.||:::.      |.|:...
Mouse   632 PQEEKLRAQLEEEKGRYKTAFMHLKALKVEIEHLQLLMDKAKVKLQKEFEAW------WAEEATS 690

  Fly   609 WQLKCVA 615
            .|:...|
Mouse   691 LQVNSPA 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	134/346 (39%)
		Kinesin	26..352	CDD:278646	134/339 (40%)
		RILP-like	<437..556	CDD:304877	39/218 (18%)
Kif6	NP_796026.2	KISc_KIF9_like	5..343	CDD:276826	134/343 (39%)
		Kinesin	11..345	CDD:278646	134/339 (40%)
		Cob_adeno_trans	<350..>408	CDD:294596	19/68 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810