Protein Alignment Klp64D and Kif6

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_796026.2
• Gene: Kif6 / 319991
• MGIID: 1098238
• Length: 802
• Species: Mus musculus
• Alignment Length: 722
• Identity: 211/722 - (29%)
• Similarity: 338/722 - (46%)
• Gaps: 153/722 - (21%)

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATA----NEPPKTY--YFDNVFDGG 77
            :.:::..|.:|..:.: ..|..|....:|:..::.::.|...|    |...::|  .|..:||..
Mouse     4 QTIQIFARVKPTVRKQ-QQGIYSIDEDEKLTHSLEIVLPRDLADGFVNNKRESYKFKFQRIFDQE 67

  Fly    78 SNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIA 142
            :.|..::...|:|:.:..|.||||||.||||||:|||:|::|..:....:||||...::||..:.
Mouse    68 AKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQ 132

  Fly   143 KAKENQKFLVRVSYMEIYNEEVRDLLG--------KDVGKSLEVKERPDIGVFVKDLSGYVVHNA 199
            | ..::.:...:||:|||||...|||.        :|:.| :.:.|.||..:.:|:||.:.....
Mouse   133 K-DSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPK-VTILEDPDQNIHLKNLSLHQATTE 195

  Fly   200 DDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQ 264
            ::..|::.||:.||.:..|.|||.|:|||.||::.:...|.|...|:|   .||.|||||||||.
Mouse   196 EEALNLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSATVRH---AKLHLVDLAGSERV 257

  Fly   265 SKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATI 329
            |||...|..|.||..|||||..|..||.||.:...||||||||.:|.:|:||||||..|.|.||:
Mouse   258 SKTGVGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIPYRNSMMTSVLRDSLGGNCMTTMIATL 322

  Fly   330 SPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEEPPSS 394
            |....|..|:|||.|:|.|...|:|...:|||....|:      |.||:|::|:   |:.|...:
Mouse   323 SLEKRNIDESISTCRFAQRVALIKNEAILNEEIDPRLM------IVRLQKEIED---LKAELAMA 378

  Fly   395 EEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTDAEKEEL------AKRKNEHQKEIEHA 453
            ..|:.| :...||.| ::||......:|.:..:.|.:..|:..::      .|:....:|.:|:.
Mouse   379 TGEQRT-EALTEAEL-LQLEKLIASYLEDQDPESRLEVGADMRKIHHCFHHFKKLLNDKKTLENT 441

  Fly   454 KTE-------QETLRN----KLVSL------EGKILVGGENLL--EKAQTQELLLEQSIAELEQ- 498
            .:.       ||.||:    ||:.|      |..|||   |:|  ||.:||:.|...|:.:.:.
Mouse   442 VSSESTRQACQEPLRDEEYTKLLGLLKQRDNEINILV---NMLKKEKKKTQDALQNSSLEKSDTR 503

  Fly   499 ---------------------------------------HEKS----------EEAL-------- 506
                                                   |:|:          :||.
Mouse   504 PPQNSPFIAGSPAVPRTPFSSAPSHTQDLSICRHRSSLLHKKTGMREEMSLGRQEAFEIFKRDHA 568

  Fly   507 --------KQTLQQKATER----IDIEERYSTLQDASTGITKKIHRVMQMLMG-----VKSELAD 554
                    ||.|:|:.:|.    ..|.|..|.:......|.::  .:.|:.:|     |.:...|
Mouse   569 DSVTIEDNKQVLKQRFSEAKALGESINEARSKIGQLKDAINQR--HLQQVALGISENTVPASTPD 631

  Fly   555 QQQEHQR----EKEGIYE----NIRSLSRELALCELVLNS---YVPKEYQSMINQYTHWNEDIGE 608
            .|:|..|    |::|.|:    ::::|..|:...:|:::.   .:.||:::.      |.|:...
Mouse   632 PQEEKLRAQLEEEKGRYKTAFMHLKALKVEIEHLQLLMDKAKVKLQKEFEAW------WAEEATS 690

  Fly   609 WQLKCVA 615
            .|:...|
Mouse   691 LQVNSPA 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	134/346 (39%)
		Smc	<433..>578	CDD:440809	48/252 (19%)
Kif6	NP_796026.2	KISc_KIF9_like	5..343	CDD:276826	134/343 (39%)
		GumC	<557..>726	CDD:442439	30/149 (20%)