DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Kif26a

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_006240697.1	Gene:	Kif26a / 314473	RGDID:	1307957	Length:	1881	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	136/509 - (26%)
Similarity:	233/509 - (45%)	Gaps:	87/509 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKP-----------NATANEPPKTYYFDNVF 74
            |:|::|..|....:.||.:.|.:.||...:.:|:..|           :|.....||.:.||.:|
  Rat   365 VKVMLRIWPAQGVQRSAESTSFLKVDSRKKQVTLYDPAAGPPGCAGLRHAPTAPVPKMFAFDAIF 429

  Fly    75 DGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFG 139
            ...|.|.::...|...::..|:.|.:|.|.::|....||:|||.|...|||:.||:|.|.:.:|.
  Rat   430 PQDSEQAEVCSGTVADVLQSVVGGADGCIFSFGHMSLGKSYTMIGKDSSPQSLGIVPCAISWLFR 494

  Fly   140 HIAKAKE--NQKFLVRVSYMEI--YNEEVRDLLGKDVGKSLEVKERPDIGVFVKD--LSGYVVHN 198
            .|.:.||  ..:|.:|||.:|:  :::.:||||.:.....|:..:.|  ||::::  :.|..:.|
  Rat   495 LIDERKERLGTRFSIRVSAVEVCGHDQSLRDLLAEVASGCLQDTQSP--GVYLREDPVCGTQLRN 557

  Fly   199 ADDLENIMRLGNKNRA---VGATKMNQESSR----------SHAIFSITVER---SELGEGDVQH 247
                :|.:|.....:|   :.|....:.:||          ||.:|::.|.:   .:.|:|.:..
  Rat   558 ----QNELRAPTAEKAAFYLDAALAARSTSRAGCGEDARRTSHMLFTLHVYQYRVEKCGQGGMSG 618

  Fly   248 VRMGKLQLVDLAGSERQSKTQASGQRLKEAT--KINLSLSVLGNVISALVDGKSTHIPYRNSKLT 310
            .| .:|.|:||...|      |:..|..||:  .:.||||.||:||.|||:| :.|:|||:..||
  Rat   619 GR-SRLHLIDLGSCE------AAPSRGGEASGGPLCLSLSALGSVILALVNG-AKHVPYRDHTLT 675

  Fly   311 RLLQDSLGGNS-KTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEI 374
            .||::||...| .|.|.|.||.:.:::.||:||::.|:|...::.:...:...........:|..
  Rat   676 MLLRESLATTSCCTTMIAHISDSPTHHAETLSTVQLAARIHRLRRKKGKHASSSSGGESSCEEGR 740

  Fly   375 ARLRKQL-------------EEGDSLEEEPPSSEEEEDTADDEL-EAPLEIELESSTIQAVEKKP 425
            ||....|             ....:|..:|..|...|.:.|..: ..|....|..
  Rat   741 ARRPPHLRPFHPRTVVLDPDRSAPALSGDPDYSSSSEQSCDTVIYVGPGGTALSD---------- 795

  Fly   426 KKKREKTDAEK--------EELAKRK-NEHQKEIEHAKTEQ-ETLRNKLVSLEG 469
               ||.||.|.        ..|::|: :|..::.:|.:... ..|:.:|..::|
  Rat   796 ---RELTDNEGPPDFVPIIPALSRRRPSEGPRDADHFRCSTFAELQERLECIDG 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	113/366 (31%)
		Kinesin	26..352	CDD:278646	111/361 (31%)
		RILP-like	<437..556	CDD:304877	7/35 (20%)
Kif26a	XP_006240697.1	KISc	364..716	CDD:276812	113/364 (31%)
		KISc	365..725	CDD:214526	113/373 (30%)
		PRK07764	<837..1309	CDD:236090	3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900