Protein Alignment Klp64D and Kif19

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001402044.1
• Gene: Kif19 / 303659
• RGDID: 1559936
• Length: 997
• Species: Rattus norvegicus
• Alignment Length: 756
• Identity: 228/756 - (30%)
• Similarity: 349/756 - (46%)
• Gaps: 133/756 - (17%)

  Fly    15 DDEIENVRVVVRTRPMDKNELSAGA-LSAISVDKINRAITVMKPNATANEPP-----------KT 67
            |.:.:.:.|.:|.||:..:||..|| |.|..||:  :.:.:|.|    .|.|           |:
  Rat     6 DSKDQQLMVALRVRPISVSELEEGATLIAHKVDE--QMVVLMDP----MEDPDDILRAHRSREKS 64

  Fly    68 YYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPN 132
            |.||..||..:.|..:|..|.:.:::.|:.|||.|:.|||.||.||||||.|....|   ||...
  Rat    65 YLFDVAFDFTATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTDHEP---GIYVR 126

  Fly   133 AFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVH 197
            ....:|..|.:...:.::.|.:||:|||||.:||||...:| .||::|.....:.|..::.....
  Rat   127 TLNDLFRAIEETSNDMEYEVSMSYLEIYNEMIRDLLNPALG-YLELREDSKGVIQVAGITEVSTI 190

  Fly   198 NADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSE 262
            ||.::..::..||:.|....|..||.||||||:..:.|.:....:..:|.||.|:|.::||||||
  Rat   191 NAKEIMQLLMKGNRQRTQEPTAANQTSSRSHAVLQVAVRQRNRVKNILQEVRQGRLFMIDLAGSE 255

  Fly   263 RQSKTQASGQRLKEATKINLSLSVLGNVISALVD-GKSTHIPYRNSKLTRLLQDSLGGNSKTVMC 326
            |.|:||..|||:||...||.||..|||.|:||.| |.:.:|.||:|||||||:|||||||:|||.
  Rat   256 RASQTQNRGQRMKEGAHINRSLLALGNCINALSDKGGNKYINYRDSKLTRLLKDSLGGNSRTVMI 320

  Fly   327 ATISPADSNYMETISTLRYASRAKNIQNRM---------HINEEPKDALLRHFQEEIARL----- 377
            |.||||.:.:.|:.:||.||.|||||:.|:         ||.:  ..:::...:.||.||
  Rat   321 AHISPASTAFEESRNTLTYAGRAKNIRTRVKQNLLNVSYHIAQ--YTSIIADLRGEIQRLKCKID 383

  Fly   378 --------RKQLEEGD----SLEEEPPSSEEEEDTADD--------------------ELE-APL 409
                    |.:|:.||    ..|.:..|.:||:.....                    ||| ..:
  Rat   384 QQAGRGQARGKLDRGDIRHIQAEVQLHSGQEEQAEMGQLREQLISAFHEQMDVRRRLLELENQAM 448

  Fly   410 EIELESS----TIQAVEKKPKKKREKTDAEKEELAKRKNEHQKEIEHAKTEQETLRNKLVSLEGK 470
            |:::::|    ||.:.|.:..::..|...|:.:.:..|.:.:|:.:...........::.|....
  Rat   449 EVQIDTSRHLLTIASWEHEKSRRALKWREERRKESYTKEDSEKDSDTGDEPDNLEPPEVASAREN 513

  Fly   471 I--LVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTG 533
            |  |||.:..|.|   ::|.|||...||       .|..:.|::....||..||:...|     .
  Rat   514 IAALVGEQKKLRK---EKLALEQRCREL-------RARGRRLEETLPRRIGSEEQREVL-----S 563

  Fly   534 ITKKIH--RVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVL----------NS 586
            :..::|  .|....|...:.|.|....|:||.      :|.|.:..:||:.::          |.
  Rat   564 LLCRVHELEVENTEMQSHALLRDSALRHRREA------VRRLEQHRSLCDEIIQGQRQIIDDYNL 622

  Fly   587 YVPKEYQSMINQYTHWNEDIGEWQLKCV-------AYTGNNMRKHISAHKTSGKEPDFLDL---- 640
            .:|:..:.:...|....|: |..:...:       |...:::.|...|..|...:.|...:
  Rat   623 EIPRHLEELYEVYLRELEE-GSLERATIMDRVASRALQDSSLPKITPAGTTLTPDSDLESVKTLS 686

  Fly   641 SHVYLSYN-------TDGVSNPMRSKSARP---RTSGVPRP 671
            |......|       ||..|..|...|.|.   ::|.||.|
  Rat   687 SEAQCPQNNTLPPLGTDSDSYHMFKASPRAWQVKSSSVPTP 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	144/345 (42%)
		Smc	<433..>578	CDD:440809	33/148 (22%)
Kif19	NP_001402044.1	KISc_KIP3_like	11..346	CDD:276821	144/344 (42%)
		Smc	<340..>605	CDD:440809	63/287 (22%)