Protein Alignment Klp64D and Kif3b

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001099999.1
• Gene: Kif3b / 296284
• RGDID: 1306815
• Length: 747
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 304/639 - (47%)
• Similarity: 424/639 - (66%)
• Gaps: 44/639 - (6%)

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |:||||||.|||:..|.:|.....:.||.....::|..|..|::|.|||:.||.|:|..:.|.:|
  Rat     8 ESVRVVVRCRPMNGKEKAAAYDKVVDVDVKLGQVSVKNPKGTSHEMPKTFTFDAVYDWNAKQFEL 72

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |.:|.||:||.||:|:||||.|||||||||||||.|....|:.:|:|||:|.|||.||::: :||
  Rat    73 YDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVRGDPEKRGVIPNSFDHIFTHISRS-QNQ 136

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            ::|||.||:|||.||:||||.||..|.||:|||||.||:|||||.:|..:..::|::|.:||:||
  Rat   137 QYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNR 201

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEAT 278
            :||||.||:.||||||||.||||.||:|.....|:|:|||.||||||||||:||.|.|:||||||
  Rat   202 SVGATNMNEHSSRSHAIFVITVECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEAT 266

  Fly   279 KINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTL 343
            |||||||.|||||||||||||||||||:||||||||||||||:||||.|.:.||..|..||::||
  Rat   267 KINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTL 331

  Fly   344 RYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEE---------------------GDSL 387
            |||:|||||:|:..:||:|||||||.||||||||:.|||:                     |:..
  Rat   332 RYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEE 396

  Fly   388 EEEPPSSEEEEDTADD---ELEAPLEIE----LESSTIQAVEKKPKKKREKTDAEKEELAKRKNE 445
            |||....|||.|..||   |.:..||||    :|..::.|             .||..|.|.|.:
  Rat   397 EEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVA-------------EEKMRLLKEKEK 448

  Fly   446 HQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTL 510
            ..:::...|...|.|..|:.::|.|:||||:|:::....|:.:|||...|:.:.::.|..::|.:
  Rat   449 KMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQM 513

  Fly   511 QQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSR 575
            :.:..|.::::|.|::||......|||:.::...|..||:|:.|.|:||.:|::.:.:....|:|
  Rat   514 ESRDEETLELKETYTSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTR 578

  Fly   576 ELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNN--MRKHISA 627
            ||.|..|::.:::|.|.::.|...:.::::...|:|..:....|.  |::.:||
  Rat   579 ELKLKHLIIENFIPLEEKNKIMNRSFFDDEEDHWKLHPITRLENQQMMKRPVSA 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	209/332 (63%)
		Smc	<433..>578	CDD:440809	43/144 (30%)
Kif3b	NP_001099999.1	KISc_KIF3	8..340	CDD:276822	209/332 (63%)
		Smc	<355..>581	CDD:440809	73/238 (31%)