DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp64D and KIF4B

DIOPT Version :10

Sequence 1:NP_523934.1 Gene:Klp64D / 38611 FlyBaseID:FBgn0004380 Length:677 Species:Drosophila melanogaster
Sequence 2:NP_001092763.1 Gene:KIF4B / 285643 HGNCID:6322 Length:1234 Species:Homo sapiens


Alignment Length:788 Identity:232/788 - (29%)
Similarity:347/788 - (44%) Gaps:234/788 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LDDEIEN--VRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDG 76
            :.:|::.  |||.:|.||:...|:|.|....:|.......:.|        ...|::.:|.|||.
Human     1 MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGETQVVV--------GTDKSFTYDFVFDP 57

  Fly    77 GSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSG----NPDSPQTKGIIPNAFAHI 137
            .:.|.:::.....|::..:.:|||.|:|||||||:||||:|.|    ..::..|.||||.....:
Human    58 CTEQEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRVIQLL 122

  Fly   138 FGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKS-LEVKERPDIGVFVKDLSGYVVHNADD 201
            |..|.| |.:.:|.::|||:||||||:.|||.....|: :.::|.|..|:.:..|:...|..|.|
Human   123 FKEIDK-KSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALD 186

  Fly   202 LENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSK 266
            ..:.:..||.:|.|.:|.||.:||||||||:|::|:.:  :.|.......||.||||||||||.|
Human   187 TVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRK--KSDKNCSFRSKLHLVDLAGSERQKK 249

  Fly   267 TQASGQRLKEATKINLSLSVLGNVISALVDG-KSTHIPYRNSKLTRLLQDSLGGNSKTVMCATIS 330
            |:|.|.||||...||..|..||||||||.|. |.:.:|||:|||||||||||||||.|:|.|.:|
Human   250 TKAEGDRLKEGININRGLLCLGNVISALGDDKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVS 314

  Fly   331 PADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQL-------------- 381
            |||||..||:||||||.||:.|:|:..:|.:|..|.|.|.::::.:|:..|              
Human   315 PADSNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQLQVLLLQAHGGTLPGSINA 379

  Fly   382 ---EEGDSLEEEPPSSEEE---------------------------------------------- 397
               |...||.|:..|..||                                              
Human   380 EPSENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHVACK 444

  Fly   398 -------EDTADDELEAPLEI---------ELESSTIQA--------------VEKKPKKKREKT 432
                   |...|.||:..:||         :|...|:..              ||..|:..| .:
Human   445 LDLQKLVETLEDQELKENVEIICNLQQLITQLSDETVACTAAAIDTAVEEEAQVETSPETSR-SS 508

  Fly   433 DA--------------------------------------------------------------- 434
            ||                                                               
Human   509 DAFTTQHALHQAQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQK 573

  Fly   435 EKEELAKRKNEHQKEIEHAKTEQETLRNKLV-SLEGKILVGGENLLEKAQTQELLL------EQS 492
            |||||.:.....:|.:..||..:.  |:||: .|||:|    .:|.:|...|..||      |::
Human   574 EKEELVRELQTAKKNVNQAKLSEH--RHKLLQELEGQI----ADLKKKLNEQSKLLKLKESTERT 632

  Fly   493 IAELEQH---------------EKSEEALKQTLQQKATERIDIEER-----YSTLQ--------- 528
            :::|.|.               ::..|..:|..|:|..|.|.::||     |..|:         
Human   633 VSKLNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQS 697

  Fly   529 -------DASTGITKKIHRVMQMLMGVKSELADQQQEHQRE-KEGIYENIRS-LSRELALCELVL 584
                   :.:....|::...:|.    :.|:.|:::|.|.. ||||...:|: |..|:   |:::
Human   698 SVLRRKTEEAAAANKRLKDALQK----QREVTDKRKETQSHGKEGIAARVRNWLGNEI---EVMV 755

  Fly   585 NSYVPKEY 592
            ::...|.:
Human   756 STEEAKRH 763

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp64DNP_523934.1 KISc_KIF3 19..352 CDD:276822 153/340 (45%)
Smc <433..>578 CDD:440809 48/252 (19%)
KIF4BNP_001092763.1 KISc_KIF4 8..337 CDD:276823 153/339 (45%)
Smc <429..>986 CDD:440809 62/349 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..513 6/19 (32%)
Interaction with PRC1. /evidence=ECO:0000250|UniProtKB:O95239 663..1234 24/108 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..737 6/28 (21%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O95239 793..798
Globular. /evidence=ECO:0000250 1000..1234
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1030
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1076
CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000250|UniProtKB:O95239 1086..1144
SET 1086..>1126 CDD:394802
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1122..1143
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1183..1234
Blue background indicates that the domain is not in the aligned region.

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