DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Kif26b

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001155137.1	Gene:	Kif26b / 269152	MGIID:	2447076	Length:	2112	Species:	Mus musculus

Alignment Length:	583	Identity:	166/583 - (28%)
Similarity:	261/583 - (44%)	Gaps:	105/583 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VRVVVR---TRPMDKNELSAGALSAISVDKINRAITVMKP------NA----TANEPPKTYYFDN 72
            |:|::|   |...|.:|.|    |.:.||...:.||:..|      ||    ::..|||.:.||.
Mouse   451 VKVMLRICSTSARDTSESS----SFLKVDPRKKQITLYDPLTCGGQNAFQKRSSQVPPKMFAFDA 511

  Fly    73 VFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHI 137
            ||...::|.::...|...::..|:.|.:|.:..:|....||:|||.|..||.|..||||.|.:.:
Mouse   512 VFPQDASQAEVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGRDDSMQNLGIIPCAISWL 576

  Fly   138 FGHIAKAKE--NQKFLVRVSYMEIYNEE--VRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHN 198
            |..|.:.||  ..:|.||:|.:|::.:|  :||||.:....||:..:.|.:.:....:.|..:.|
Mouse   577 FKLINERKEKTGARFSVRISAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYLCEDPICGTQLQN 641

  Fly   199 ADDLENIMRLGNK-----NRAVGATKMNQES------SRSHAIFSITV-----ERSELGEGDVQH 247
            ..:|.  .....|     :.|:.:.:.||:.      ..||.:|::.:     |:|  |:|.:..
Mouse   642 QSELR--APTAEKAAFFLDAAIASRRSNQQDCDEDDHRNSHMLFTLHIYQYRMEKS--GKGGMSG 702

  Fly   248 VRMGKLQLVDLAGSERQ-SKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTR 311
            .| .:|.|:||....:. ||.:..|..|      .||||.|||||.|||:| |.||||:.||||.
Mouse   703 GR-SRLHLIDLGSCVKALSKNREGGSGL------CLSLSALGNVILALVNG-SKHIPYKESKLTM 759

  Fly   312 LLQDSLGG-NSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIA 375
            ||::|||. |.:|.|.|.||.|.|:|.||:||::.|||...::.:...............:|...
Mouse   760 LLRESLGNVNCRTTMIAHISAAASSYAETLSTIQIASRVLRMKKKKTKYTSSSSGGESSCEEGRM 824

  Fly   376 RLRKQLEEGDS------------LEEEP---PSSEEEEDT-----------ADDEL---EAPLEI 411
            |...||....:            |..:|   .|||:..||           :|.||   |.|.:.
Mouse   825 RRPTQLRPFHARAPVDPEFPLAPLSSDPDYSSSSEQSCDTVIYIGPNGTALSDKELTDNEGPPDF 889

  Fly   412 ELESSTIQAVEKKPKKKREKTDAEKEELAKRKNEHQKEIEHAKTEQETLR-NKLVSLEGKI-LVG 474
                     |...|..::.:.|:...|.|        |...:|:|::.|: |....|:.:: .:.
Mouse   890 ---------VPIVPALQKTRGDSRPGEAA--------EAAASKSERDCLKCNTFAELQERLDCID 937

  Fly   475 GENLLEKAQTQELLL----EQS--IAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDAS 531
            |.....|...:||.:    ||:  .|.|.|....:...:...:...::...:.||..|...||
Mouse   938 GSEEPSKFPFEELPIQFGPEQAGRCAPLSQAVGPDTPSESEKEDNGSDNGQLTEREGTELPAS 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	125/365 (34%)
		Kinesin	26..352	CDD:278646	123/360 (34%)
		RILP-like	<437..556	CDD:304877	22/103 (21%)
Kif26b	NP_001155137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..286
		KISc	450..798	CDD:276812	124/362 (34%)
		KISc	451..798	CDD:214526	124/362 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..859		7/53 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..917		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	955..1165		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1405..1501
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1569..1649
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1687..1734
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1748..1801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1816..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1899..1971
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900