DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and cut7

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_594527.1	Gene:	cut7 / 2542732	PomBaseID:	SPAC25G10.07c	Length:	1085	Species:	Schizosaccharomyces pombe

Alignment Length:	782	Identity:	229/782 - (29%)
Similarity:	357/782 - (45%)	Gaps:	164/782 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QEEANAGTTAQLDDEIE-NVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPK 66
            :.:.|:.|...|.||.| |:.||||.|.....|:...:..|:|......|...::.:.::....|
pombe    54 RSDTNSPTDHALHDENETNINVVVRVRGRTDQEVRDNSSLAVSTSGAMGAELAIQSDPSSMLVTK 118

  Fly    67 TYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGN-PDS----PQT 126
            ||.||.||...::|:.|:.::..|::::||.|||.||.|||||||||||||||: .||    .:.
pombe   119 TYAFDKVFGPEADQLMLFENSVAPMLEQVLNGYNCTIFAYGQTGTGKTYTMSGDLSDSDGILSEG 183

  Fly   127 KGIIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLL-GKDVGKSLEVKERPDI--GVFV 188
            .|:||.|...:|..:..:  ||::.|:.||.|:||||:|||| .:::.|...|.|....  .|.:
pombe   184 AGLIPRALYQLFSSLDNS--NQEYAVKCSYYELYNEEIRDLLVSEELRKPARVFEDTSRRGNVVI 246

  Fly   189 KDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERS------------ELG 241
            ..:....:.||.|...::|.|:..|.|.|||.|..|||||:||:||:.|.            .:.
pombe   247 TGIEESYIKNAGDGLRLLREGSHRRQVAATKCNDLSSRSHSIFTITLHRKVSSGMTDETNSLTIN 311

  Fly   242 EGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRN 306
            ......:|..||.:|||||||...::.|..:|.:|...||.||..||.||:|||: |:.|||||.
pombe   312 NNSDDLLRASKLHMVDLAGSENIGRSGAENKRARETGMINQSLLTLGRVINALVE-KAHHIPYRE 375

  Fly   307 SKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEP-KDALLRHF 370
            |||||||||||||.:||.|..|:|..::|..||||||.||:|||:|:|:...|:.. :..|::..
pombe   376 SKLTRLLQDSLGGKTKTSMIVTVSSTNTNLEETISTLEYAARAKSIRNKPQNNQLVFRKVLIKDL 440

  Fly   371 QEEIARLRKQLEE---------GDSLEEEPPSSEEEEDTADDELEAPLEI---ELESS--TIQAV 421
            ..:|.||:..|..         .:|..:|.....:.:|....|....||:   .::||  .:|.|
pombe   441 VLDIERLKNDLNATRKKNGVYLAESTYKELMDRVQNKDLLCQEQARKLEVLDLNVKSSREQLQYV 505

  Fly   422 EKKPKKKREKTDAEKEELAKRKNEHQKEIEHAKTEQETLRNKLV----------SLEGKILVGGE 476
            .|..::.:::.:|.:.:|.....    |:|..|:|.|.|:|:||          :.|.||.....
pombe   506 SKSNQEHKKEVEALQLQLVNSST----ELESVKSENEKLKNELVLEIEKRKKYETNEAKITTVAT 566

  Fly   477 NLLE------------------------------------------------------------- 480
            :|.:
pombe   567 DLSQYYRESKEYIASLYEKLDRTERNNKENENNFWNLKFNLLTMLRSFHGSFTDETNGYFTLLND 631

  Fly   481 -KAQTQELL------LEQSIAELEQHEKS-EEALKQTLQQKATERIDIEERYSTLQDASTGITKK 537
             .|..:|||      |..|:.::.:|.:| :|||:......|.....::...|.|:|:...:...
pombe   632 FNASMEELLNTHSNQLLISMTKITEHFQSLDEALQSARSSCAVPNSSLDLIVSELKDSKNSLLDA 696

  Fly   538 IHRVMQMLM--------GVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQS 594
            :...:|.:.        |:.|||.:.|::       :.|:.|.|.:||               :|
pombe   697 LEHSLQDISMSSQKLGNGISSELIELQKD-------MKESYRQLVQEL---------------RS 739

  Fly   595 MIN-QYTHWNEDIGEWQLKCVAYTGNNMRKHISAHKTSGKEPDFL------DLSHVYLSYNTDGV 652
            :.| |:||     .|.|.:.:....|::...:....||..:.|.:      |....:.|...|.:
pombe   740 LYNLQHTH-----EESQKELMYGVRNDIDALVKTCTTSLNDADIILSDYISDQKSKFESKQQDLI 799

  Fly   653 SN 654
            :|
pombe   800 AN 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	149/353 (42%)
		Kinesin	26..352	CDD:278646	144/345 (42%)
		RILP-like	<437..556	CDD:304877	34/205 (17%)
cut7	NP_594527.1	KISc_BimC_Eg5	70..429	CDD:276815	151/361 (42%)
		KISc	72..428	CDD:214526	150/358 (42%)
		SbcC	<398..>966	CDD:223496	88/435 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940