Protein Alignment Klp64D and Kif18a

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001405889.1
• Gene: Kif18a / 228421
• MGIID: 2446977
• Length: 919
• Species: Mus musculus
• Alignment Length: 842
• Identity: 236/842 - (28%)
• Similarity: 372/842 - (44%)
• Gaps: 210/842 - (24%)

  Fly    15 DDEIENVRVVVRTRPMDKNELSAGALSAI--------SVDKINRAITVMKPNATAN-------EP 64
            :|....::||||.||.:..|.:......:        |.|.....|:......|.|       ..
Mouse     6 EDLCHRMKVVVRVRPENTKEKAVQFCKVVHVVDKHILSFDPKQEEISFFHRKKTTNFDITKRQNK 70

  Fly    65 PKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGI 129
            ...:.||.|||..|.||:::..|.:||:...|.|||.|:.|||.||:|||:||.|:...|   |:
Mouse    71 DLKFVFDAVFDETSTQMEVFEHTTKPILHSFLNGYNCTVFAYGATGSGKTHTMLGSAAEP---GV 132

  Fly   130 IPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGY 194
            :......:|..|.:.||.::....|||:|:|||::||||..  ...|.|:|....||.|:   |.
Mouse   133 MYLTMLDLFKCIDEIKEEKECSTAVSYLEVYNEQIRDLLTN--SGPLAVREDSQKGVVVQ---GL 192

  Fly   195 VVHNADDLENIMRL---GNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLV 256
            .:|.....|.|::|   |||||....|.:|..||||||:|.|.:.:.:......|:||:.|:.|:
Mouse   193 TLHQPKSSEEILQLLDNGNKNRTQHPTDVNAVSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLI 257

  Fly   257 DLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGK--STHIPYRNSKLTRLLQDSLGG 319
            |||||||.|.:.|.|.|..|.|.||.||..|||||:||.:.|  :.|||||||||||||:|||||
Mouse   258 DLAGSERASVSGAKGSRFVEGTNINKSLLALGNVINALANTKRRNQHIPYRNSKLTRLLKDSLGG 322

  Fly   320 NSKTVMCATISPADSNYMETISTLRYASRAKNIQNRM---------HINEEPKDALLRHFQEEIA 375
            |.:|:|.|.:||:...|.:|.:||:||:|||.|::.:         ||::..|...::  :.||.
Mouse   323 NCQTIMIAAVSPSSLFYDDTYNTLKYANRAKEIKSSLKSNVLNLNSHISQYVKICNMQ--KAEIL 385

  Fly   376 RLRKQLEEGDSLEEEPPSSEEEE-------DTADDELE--------------------APLEIEL 413
            .|:::|:   :.||:...|:..:       :..|.|.|                    ..||:.|
Mouse   386 MLKEKLK---AYEEQKALSDRNDCAKLVHSNPEDRETERFQEILNCLFQNREGIRQEYLKLEMLL 447

  Fly   414 ESSTIQA------------------VEKKPKKK-----REKTDA-----EKEELAKRKNEHQKEI 450
            :::.:::                  |||...|:     :.||::     :|||::|:.:|:...:
Mouse   448 KANALKSSYHQQCHKQIEMMCSEDKVEKATCKRDHRLEKLKTNSCFLEKKKEEVSKQFDENTNWL 512

  Fly   451 EHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKAT 515
            ...:.|.     :|:...|.|   .|.|.::.....|.|:....:.:....:..|..|..|.|.|
Mouse   513 HRVENEM-----RLLGQNGDI---PEALNKELHCHHLHLQNKELKTQMAHMTALACLQEQQHKQT 569

  Fly   516 ERI------DIEERYSTLQDASTGIT--------KKIHRVMQMLMGVKSELADQQQEHQREKE-- 564
            |.:      .:.::|..|::  ||::        |.|..:::....|  ..|||..||....:
Mouse   570 EAVLNALLPVLRKQYWKLKE--TGLSNAAFDSDFKDIEHLVERKKVV--AWADQTNEHSNRNDLP 630

  Fly   565 GI--------YENIRSLSRELALCELVLNSYVPK--------------------EYQSMINQYTH 601
            ||        .|.|:|:|    .|..|.:..|.|                    ..:|.:::.|.
Mouse   631 GISLLMTFPQLEPIQSIS----CCTSVSDPNVLKLTPQRRTRRKIIPSPLKVQHTQKSALSESTQ 691

  Fly   602 WNEDIGEWQLKCVAYTGNNMRK----HISAHKTSGKEPDFLD-------------LSHVYLS--- 646
            .|:...: :|:.:.||..:.:|    ..|..:||.:..:.::             ||.....
Mouse   692 LNDSFSK-ELQPIVYTPEDCKKAQDLFPSLTRTSSQSANVMNDNSQKALCRIESPLSRTECKQGL 755

  Fly   647 YNTD-------GVSN------PMRS---------------KSARPRTSGVP----RPTTARR 676
            |:|.       |:.|      |:.|               |.:.|.::|||    ..|.|:|
Mouse   756 YSTSTLCDSIRGLKNKWPEQEPLASSKSSVHRIESSSFSTKDSMPESAGVPSYMAMTTAAKR 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	145/352 (41%)
		Smc	<433..>578	CDD:440809	37/173 (21%)
Kif18a	NP_001405889.1	KISc_KIP3_like	11..355	CDD:276821	145/351 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	774..804		4/29 (14%)