Protein Alignment Klp64D and Kif15

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_034750.1
• Gene: Kif15 / 209737
• MGIID: 1098258
• Length: 1387
• Species: Mus musculus
• Alignment Length: 644
• Identity: 220/644 - (34%)
• Similarity: 332/644 - (51%)
• Gaps: 100/644 - (15%)

  Fly    13 QLDDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGG 77
            |..:|.:.::|.||.||.::...||....:..:..:::  |.::.:  :|..|||:.||.|....
Mouse    19 QPSNEGDAIKVFVRIRPAEEGARSADGEQSFCLSVLSQ--TTLRLH--SNPDPKTFVFDYVAGMD 79

  Fly    78 SNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSP----QTKGIIPNAFAHIF 138
            :.|..::...|:.||:..:.||||||.||||||:|||:||.|..||.    ..:||||.:|.::|
Mouse    80 TTQESVFSTVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSDSDNFSHNLRGIIPRSFEYLF 144

  Fly   139 GHIAKAKE----NQKFLVRVSYMEIYNEEVRDLL-GKDVGKSLEVKERPDIGVFVKDLSGYVVHN 198
            ..|.:.||    .:.||.:.|::|:|||::.||| ...||  |.::|....||||.......|.:
Mouse   145 SLIDREKEKAGAGKSFLCKCSFIEVYNEQIYDLLDSASVG--LYLREHIKKGVFVVGAVEQAVTS 207

  Fly   199 ADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSER 263
            |.:...::..|.:||.|.:|.||:|||||||:|:||:|..|.....| ::|...|.|||||||||
Mouse   208 AAETYQVLSRGWRNRRVASTSMNRESSRSHAVFTITIESMEKSSETV-NIRTSLLNLVDLAGSER 271

  Fly   264 QSKTQASGQRLKEATKINLSLSVLGNVISALVD---GKSTHIPYRNSKLTRLLQDSLGGNSKTVM 325
            |..|.|.|.|||||..||.|||.||.||:||||   ||..||.||:||||.||:||||||:||.:
Mouse   272 QKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHICYRDSKLTFLLRDSLGGNAKTAI 336

  Fly   326 CATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEE 390
            .|.:.|....:.||:|||.:|.|||.|:|:..:||:.: ..:...|.|:.||::||.:..|.:..
Mouse   337 IANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQ-GNVSQLQAEVKRLKEQLSQFTSGQIT 400

  Fly   391 PPS--SEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTDAEKEELAKRKNEHQKEIEHA 453
            |.|  :.::|.|      ..:|..||:.......::.||...:...:.|:|..:|   :|.|:..
Mouse   401 PESLLARDKEKT------NYIEYFLEAMLFFKKSEQEKKSLIEKITQLEDLTLKK---EKFIQSN 456

  Fly   454 K-----TEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLE------QSIAE------------ 495
            |     .|.:.:|.:.:..||:    |..|.|:   |:.||.      |::.|
Mouse   457 KMIVKFREDQIMRLERLHKEGR----GSFLPEE---QDRLLSELRDEVQTLREHVEHHPRLAKYA 514

  Fly   496 LEQHEKSEE--ALKQTLQQKATERID------IEERYSTLQDAST------GITKK--------- 537
            :|.|...||  .||.....|....||      :|:.::.:....|      |.:.|
Mouse   515 MENHSLREENRRLKLLAPVKRAHEIDAQSIARLEKAFAEVSSTETNDKGLQGFSPKALKESSFFT 579

  Fly   538 -IHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSM 595
             ..::...|:.:::||.:.:||        ||..:.|:|:.   :|.|.|    |.||:
Mouse   580 NTEKLKAQLLQIQTELNNSKQE--------YEEFKELTRKK---QLELES----ELQSL 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	152/344 (44%)
		Smc	<433..>578	CDD:440809	40/191 (21%)
Kif15	NP_034750.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		1/3 (33%)
		KISc_KLP2_like	25..373	CDD:276824	156/354 (44%)
		SMC_prok_B	520..1339	CDD:274008	26/119 (22%)