DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp64D and Kif15

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_034750.1	Gene:	Kif15 / 209737	MGIID:	1098258	Length:	1387	Species:	Mus musculus

Alignment Length:	644	Identity:	220/644 - (34%)
Similarity:	332/644 - (51%)	Gaps:	100/644 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QLDDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGG 77
            |..:|.:.::|.||.||.::...||....:..:..:::  |.::.:  :|..|||:.||.|....
Mouse    19 QPSNEGDAIKVFVRIRPAEEGARSADGEQSFCLSVLSQ--TTLRLH--SNPDPKTFVFDYVAGMD 79

  Fly    78 SNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSP----QTKGIIPNAFAHIF 138
            :.|..::...|:.||:..:.||||||.||||||:|||:||.|..||.    ..:||||.:|.::|
Mouse    80 TTQESVFSTVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSDSDNFSHNLRGIIPRSFEYLF 144

  Fly   139 GHIAKAKE----NQKFLVRVSYMEIYNEEVRDLL-GKDVGKSLEVKERPDIGVFVKDLSGYVVHN 198
            ..|.:.||    .:.||.:.|::|:|||::.||| ...||  |.::|....||||.......|.:
Mouse   145 SLIDREKEKAGAGKSFLCKCSFIEVYNEQIYDLLDSASVG--LYLREHIKKGVFVVGAVEQAVTS 207

  Fly   199 ADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSER 263
            |.:...::..|.:||.|.:|.||:|||||||:|:||:|..|.....| ::|...|.|||||||||
Mouse   208 AAETYQVLSRGWRNRRVASTSMNRESSRSHAVFTITIESMEKSSETV-NIRTSLLNLVDLAGSER 271

  Fly   264 QSKTQASGQRLKEATKINLSLSVLGNVISALVD---GKSTHIPYRNSKLTRLLQDSLGGNSKTVM 325
            |..|.|.|.|||||..||.|||.||.||:||||   ||..||.||:||||.||:||||||:||.:
Mouse   272 QKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHICYRDSKLTFLLRDSLGGNAKTAI 336

  Fly   326 CATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEE 390
            .|.:.|....:.||:|||.:|.|||.|:|:..:||:.: ..:...|.|:.||::||.:..|.:..
Mouse   337 IANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQ-GNVSQLQAEVKRLKEQLSQFTSGQIT 400

  Fly   391 PPS--SEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTDAEKEELAKRKNEHQKEIEHA 453
            |.|  :.::|.|      ..:|..||:.......::.||...:...:.|:|..:|   :|.|:..
Mouse   401 PESLLARDKEKT------NYIEYFLEAMLFFKKSEQEKKSLIEKITQLEDLTLKK---EKFIQSN 456

  Fly   454 K-----TEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLE------QSIAE------------ 495
            |     .|.:.:|.:.:..||:    |..|.|:   |:.||.      |::.|
Mouse   457 KMIVKFREDQIMRLERLHKEGR----GSFLPEE---QDRLLSELRDEVQTLREHVEHHPRLAKYA 514

  Fly   496 LEQHEKSEE--ALKQTLQQKATERID------IEERYSTLQDAST------GITKK--------- 537
            :|.|...||  .||.....|....||      :|:.::.:....|      |.:.|
Mouse   515 MENHSLREENRRLKLLAPVKRAHEIDAQSIARLEKAFAEVSSTETNDKGLQGFSPKALKESSFFT 579

  Fly   538 -IHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSM 595
             ..::...|:.:::||.:.:||        ||..:.|:|:.   :|.|.|    |.||:
Mouse   580 NTEKLKAQLLQIQTELNNSKQE--------YEEFKELTRKK---QLELES----ELQSL 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	152/344 (44%)
		Kinesin	26..352	CDD:278646	150/337 (45%)
		RILP-like	<437..556	CDD:304877	34/165 (21%)
Kif15	NP_034750.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		1/3 (33%)
		KISc_KLP2_like	25..373	CDD:276824	156/354 (44%)
		KISc	26..370	CDD:214526	154/350 (44%)
		Kinesin-relat_1	463..551	CDD:289481	22/94 (23%)
		SMC_prok_B	520..1339	CDD:274008	26/119 (22%)
		HMMR_C	1267..>1387	CDD:292530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810