Protein Alignment Klp64D and klp-13

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001360738.1
• Gene: klp-13 / 180865
• WormBaseID: WBGene00002224
• Length: 678
• Species: Caenorhabditis elegans
• Alignment Length: 619
• Identity: 195/619 - (31%)
• Similarity: 285/619 - (46%)
• Gaps: 100/619 - (16%)

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAI-SVDKINRAITVMKPNATAN-------EPPKTYYFDNVFD 75
            :.:.||||.||::..|.|..|...: .:||  :.:.::.|....|       :..:.:.||..|.
 Worm     6 QQLTVVVRVRPLNSGEKSRKAFQCVFPLDK--KRVLLVDPEKFENNILRQNRQHERKFEFDASFG 68

  Fly    76 GGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGH 140
            ..|||.|::..|..||:|.|:||:|.|:.|||.||:|||:||.|..|.|....::......
 Worm    69 ATSNQEDVHETTTGPIIDSVVEGFNATVFAYGATGSGKTFTMIGTKDRPGLMTLMTKTLYE---- 129

  Fly   141 IAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENI 205
                |.:.::.|.:||||||||.:||||... |..||:.|.....:.|..||.....|...:..|
 Worm   130 ----KLDNQYQVLLSYMEIYNEIIRDLLNPS-GGDLELLEDERGNIRVPGLSSVKAPNLTRIMQI 189

  Fly   206 MRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQAS 270
            ::.||..|...||..|:.||||||:..:.:.:::     ..|   .||.::|||||||.|.||..
 Worm   190 LQEGNLRRTQEATMANKTSSRSHALLQVMIVKNQ-----SLH---SKLFMIDLAGSERASNTQNR 246

  Fly   271 GQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSN 335
            |.||||...||.||..|||||::|....:..:.||:|||||||:|||||.:||.|.|.::|:.||
 Worm   247 GIRLKEGAAINRSLLALGNVINSLASKTTKFVNYRDSKLTRLLKDSLGGTAKTCMIAHVTPSSSN 311

  Fly   336 YMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEEPP-------S 393
            :.||.:||.|||||.||.|: .:...|..| .:.:.|.:..:||  |.|..::....       |
 Worm   312 FEETYNTLMYASRAMNITNK-PMRNRPASA-DQVYAEAMNAIRK--EVGSQIKNSSSITGLAARS 372

  Fly   394 SEEEEDTADDELEAPLEIELESSTIQAVEKKP------------------------KKKREKTDA 434
            |.:|..::.:.   |..|...||..:|.:..|                        |:.|||..|
 Worm   373 SVQERSSSRNR---PKSISRNSSLTRAAQPMPIDRGRGGSLFTQLKEQYMTLSDKQKRLREKLMA 434

  Fly   435 EKEEL---------------AKRKNEHQK---EIEHAKTEQETLRNKLVSLEG---KILVGGENL 478
            ..:|.               |..|:.|.|   .||..|.:.|..|.:||.|..   |:    |..
 Worm   435 TNQEAYSLEMSLISKNAIINAWEKHHHDKTAESIERLKKDGELQRVRLVELSDQRTKV----EKA 495

  Fly   479 LEKAQTQELLLEQSIAELEQHEKSEEALKQTLQ------QKATERIDIEERYSTLQDASTGITK- 536
            |.|.:.....||..:..|....:..|.:|..::      ||.:...|:..|...:....|.|.|
 Worm   496 LRKGEENASGLESRMRSLASTNEQREVVKLMVKMAEIEAQKISALSDLAIRGLIMDRTDTSIAKL 560

  Fly   537 -KIHRVMQMLMGVKSELADQQQEHQREKEGIYEN 569
             |...|...|  :..:|.|..::...|:..:.:|
 Worm   561 QKYEMVADKL--IDGKLDDNDRKKLEEEYRVIKN 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	135/340 (40%)
		Smc	<433..>578	CDD:440809	37/166 (22%)
klp-13	NP_001360738.1	Motor_domain	7..328	CDD:473979	135/339 (40%)
		iSH2_PI3K_IA_R	413..>513	CDD:355389	24/103 (23%)