Protein Alignment Klp64D and klp-4

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001359864.1
• Gene: klp-4 / 180608
• WormBaseID: WBGene00002217
• Length: 1576
• Species: Caenorhabditis elegans
• Alignment Length: 649
• Identity: 220/649 - (33%)
• Similarity: 302/649 - (46%)
• Gaps: 143/649 - (22%)

  Fly    16 DEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEP-----PKTYYFDNVF- 74
            ||...|:|.:|.||.:|.||..         |....:.:.|.....:.|     .||:.||:.|
 Worm     5 DEESAVKVAIRVRPFNKRELDL---------KTKSVVRIQKEQCVLHHPIEEKNSKTFTFDHSFC 60

  Fly    75 -------DGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPN 132
                   |..|.:...| .....:|:....|||..|.||||||:||:|||.|.||.|   ||||.
 Worm    61 STDPHSYDFASQETVSY-HLGSGVVENAFSGYNACIFAYGQTGSGKSYTMMGTPDQP---GIIPR 121

  Fly   133 AFAHIFGHIAKAKENQ-KFLVRVSYMEIYNEEVRDLLG-KDVGKSLEVKERPDIGVFVKDLSGYV 195
            ....||..|.:...:. .|.|.|||||||||.|||||. |...|:|:|:|...:|..|..||...
 Worm   122 VCNDIFTRIQETSNSSLSFKVEVSYMEIYNERVRDLLDPKKSSKALKVREHKILGPMVDGLSILA 186

  Fly   196 VHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERS--ELGEGDVQHVRMGKLQLVDL 258
            |::.:.:.|::..|||:|.|.||.||.|||||||:||:.|.::  :| |......::.|:.||||
 Worm   187 VNSFEQISNLLEEGNKSRTVAATNMNAESSRSHAVFSLIVTQTLHDL-ENGFSGEKVAKISLVDL 250

  Fly   259 AGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD---GKSTHIPYRNSKLTRLLQDSLGGN 320
            |||||..||.|.|:||:|...||.||:.||.|||||.:   .|...||||:|.||.||:||||||
 Worm   251 AGSERAGKTGAVGKRLEEGGNINKSLTTLGMVISALAERNSKKDKFIPYRDSVLTWLLKDSLGGN 315

  Fly   321 SKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQL---- 381
            |:|||.||:|||..||.||:||||||.|||.|.|...|||:|...::|..:||:..||.|:
 Worm   316 SRTVMIATLSPAADNYEETLSTLRYADRAKKIVNHAIINEDPNARVIRELREEVETLRMQITQTK 380

  Fly   382 ---EEGDSLEEEPPSSE--------------EEEDTADDELEAPLE---IELESSTIQAVEKKPK 426
               .|.:.|.|....||              :|.||.:.|.:..|.   |.:|||.|:..:.:..
 Worm   381 KEHAETEELRERLAESERLVAQMNKSWEERLKETDTLNKERQKDLTEIGISIESSGIKVEKDRFY 445

  Fly   427 KKREKTDAEKEEL-------------------------------AKRKNEHQKEI---------- 450
            ......|....||                               :.|:::.::..
 Worm   446 LVNMNADPSLNELLVYYINGSAIIGNSEELETSRDSGLSMTCSDSSRRDDDKERTSIVLRGLGIM 510

  Fly   451 -EHAKTEQETLRNKL------VSLEGKILVGGENLLEKA---QTQELL----------------L 489
             .|||...|....:|      :|.|.:|.|.|:.:.|:.   ....||                :
 Worm   511 RRHAKMTVEEYGGRLRLFVAPMSSECRICVNGKQITERTLLRNGNRLLVGMNHFFKVNCPKVMDM 575

  Fly   490 EQSIAELEQ--------HEKSE-----EALKQ-----TLQQKATERIDIEERYSTLQDASTGIT 535
            ||||.|...        ||.::     .|:.|     ||:.:..::..:|::|...:.....:|
 Worm   576 EQSIMEDSTMFDYNDAWHEVNDANPISSAVDQYMESVTLKHQEDKKAALEQQYEAFEKYIQSLT 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	160/352 (45%)
		Smc	<433..>578	CDD:440809	31/188 (16%)
klp-4	NP_001359864.1	KISc_KIF1A_KIF1B	10..354	CDD:276816	162/357 (45%)
		Kinesin_assoc	351..463	CDD:465047	28/111 (25%)
		FHA_KIF13	443..570	CDD:438758	17/126 (13%)
		KIF1B	776..840	CDD:463574
		DUF3694	<1239..1293	CDD:463599