Protein Alignment Klp64D and bmk-1

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001379525.1
• Gene: bmk-1 / 179948
• WormBaseID: WBGene00000257
• Length: 963
• Species: Caenorhabditis elegans
• Alignment Length: 690
• Identity: 209/690 - (30%)
• Similarity: 331/690 - (47%)
• Gaps: 107/690 - (15%)

  Fly    20 NVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTY-YFDNVFDGGSNQMDL 83
            |:||.||.|||:..|.|....:.:.|||..:||.:         ..|:: .|...:|..:.|.::
 Worm    18 NLRVAVRIRPMNGTERSEKCTNVVKVDKGKQAIEL---------KGKSFGPFFRTYDPDTTQEEI 73

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSG-------NPDSPQTKGIIPNAFAHIFGHI 141
            |.|.....:.||:.|:|.|:.||||||||||:||.|       :.|.| |.||||.|...||..:
 Worm    74 YSDLVSSQIKKVIAGFNCTVFAYGQTGTGKTFTMEGGRTDAKSSTDDP-TTGIIPRAVEDIFEQL 137

  Fly   142 AKAKENQKFLVRVSYMEIYNEEVRDLLG---KDVGKSLEVKERPD-IGVFVKDLSGYVVHNADDL 202
            .:. ..:::.:||||:|:||||:.|||.   .:..:.|.:.:.|: .||.|..:....|.|..|:
 Worm   138 ERC-GCEEYSLRVSYIELYNEELFDLLASTDNEDRERLRIFDDPNKKGVIVSGVEEVPVRNRSDV 201

  Fly   203 ENIMRLGNKNRAVGATKMNQESSRSHAIFSITV---ERSELGEGDVQHVRMGKLQLVDLAGSERQ 264
            ..:::||.:.|...||.||..|||||::|.:.|   |.:..||   :.|:.|||.||||||||..
 Worm   202 FKLLQLGAEKRRTAATLMNMHSSRSHSLFMVNVVIRENTTTGE---ELVKQGKLNLVDLAGSENI 263

  Fly   265 SKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATI 329
            .::.|.|.|.|||..||.||..||.|| .|:.....|||||.|||||||||||||::.|.:.||:
 Worm   264 GRSGAQGNRAKEAGSINQSLLTLGRVI-RLLTTNGQHIPYRESKLTRLLQDSLGGSTITSLIATL 327

  Fly   330 SPADSNYMETISTLRYASRAKNIQNRMHINEE-PKDALLRHFQEEIARLRKQL------------ 381
            ||:.||:.|:.|||.||.||.||:|:...|.: .|..:|:.:.:||.:||:.|
 Worm   328 SPSSSNFEESQSTLEYAMRAANIKNKPVCNTKLSKKTILKEYSDEIEKLRRDLRAAREKNGVIIS 392

  Fly   382 -EEGDSLEEEPPSSEEEE---DTADDELEAPLE--IELESSTIQAVEKKPKKKREKTDAEKEELA 440
             |..|..::.....:|.|   |.|.|.|....|  :.::....|..|:|.:.:....|..:|...
 Worm   393 QESHDEFQKNSEKVQELEQHLDNAVDRLRIFTEDQMHMDEQYRQLYERKGELEDRLRDRIREMAV 457

  Fly   441 KRK---------NEHQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAEL 496
            |.|         |:|.:.|....|......::|.:.:|        ..::.||......:.:.|:
 Worm   458 KEKELADTNDVLNKHIEVIGLMHTSALKAFDQLTTSQG--------AADEMQTDLRAFWRKVDEM 514

  Fly   497 EQHEKSEEALKQTLQQKATERIDIEERY-STLQDASTGITKKI--------------HR-VMQML 545
            |:.:...:.:.....:|.::.||...:. ::|:.....::||:              || :....
 Worm   515 ERADDRNKIVIDHFSKKMSDFIDTTSKLTNSLKADGDLLSKKLSENICPHVKSMESAHRDIESTA 579

  Fly   546 MGVKSELADQQQEHQREKEGIYENIRSLSRE--------LALCELVLNSYVPK--EYQSMI---- 596
            |.:::......::....::.:.:|:.::|.|        :..|:....||..|  |:..|:
 Worm   580 MDMETHAICIMKKSSEAEKKVIDNMTAISMENRIRLETVMKTCDDFYKSYSAKSQEFTQMVVDKL 644

  Fly   597 ----NQYTHWNEDIGE-----WQLKCVAYTG--NNMRKHI 625
                .|.:.:.||:..     .|..|.:|..  |..:|::
 Worm   645 DEVKKQVSDFTEDMKPLVSTLHQTTCDSYEARTNESKKNV 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	146/346 (42%)
		Smc	<433..>578	CDD:440809	26/177 (15%)
bmk-1	NP_001379525.1	Motor_domain	17..359	CDD:473979	150/355 (42%)
		CCDC158	<365..>839	CDD:464943	58/328 (18%)