DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and klp-18

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_501093.1	Gene:	klp-18 / 177474	WormBaseID:	WBGene00002228	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	676	Identity:	199/676 - (29%)
Similarity:	300/676 - (44%)	Gaps:	170/676 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 RAITVMKPNATANEPPKTYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKT 114
            |.:|:...|.:     |.|...::||..|:|.|::...|:.||:..:||||||:.||||||:|||
Worm    29 RVVTIETDNGS-----KRYELHHIFDSSSSQEDVFGTVAKKIVEDCVEGYNGTVFAYGQTGSGKT 88

  Fly   115 YTMSGNPDS---PQTKGIIPNAFAHIFGHI-AKAKENQK--FLVRVSYMEIYNEEVRDLLG---- 169
            :||.|..||   .:..|:||.:..|:|.|: .||||.||  |.|.|.::|:|||.:.|||.
Worm    89 HTMLGPCDSWTDQELMGLIPRSVEHVFQHLDTKAKECQKLTFSVSVEFVELYNEVIYDLLNAKNK 153

  Fly   170 ---KDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIF 231
               :|.||.:::     :|...|:     |.|..||.::::.|.:.|:.|:|.||.|||||||:.
Worm   154 VQLRDSGKDIQL-----VGALSKN-----VDNPLDLMHLVQKGWQERSTGSTAMNAESSRSHALL 208

  Fly   232 SITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD 296
            .|.::..| ..|::...|...|.||||||||||:.|::||.||||||.||.||:|||..|..|.|
Worm   209 IIRIKTQE-RTGELVKERSSILNLVDLAGSERQTHTKSSGDRLKEATNINSSLTVLGRCIRLLAD 272

  Fly   297 GKST--HIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHIN 359
            ....  |:|||:|.||.:|::||||||||.:...:.|......|:.|||.:|.....|.|
Worm   273 PSKAKGHVPYRDSHLTHILKNSLGGNSKTAVIVNMHPDRDFAQESNSTLMFAQSCTMIMN----- 332

  Fly   360 EEPKDALLRHFQEEIARLRKQLEEGDSLEEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKK 424
                          || .|.::..||.                           |||..:|:::.
Worm   333 --------------IA-TRNEVMTGDQ---------------------------ESSYKKAIQEL 355

  Fly   425 PKKKREKTDAEKEELAKRKNEHQKEIEHAKTEQETLRNKLVSLEG-------KILVGGEN----- 477
            .::..|..:..:.|.|.:.:|.:.|....|||..:||.:.|.|..       |..:|.||
Worm   356 RQEVDETREKVRTEFASQLDEAEVEQLRLKTENNSLRLENVDLRAKYDFALLKYTIGSENEQIVN 420

  Fly   478 --------------------LLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERI---- 518
                                :..|.||.:|.:|.|....::.:|...||:...|:.....|
Worm   421 EFKKIISEFSAANSSSPFECIALKNQTLQLEIEASEKRYQELQKETSALRNRYQENLDATILMQT 485

  Fly   519 -DIEERYS-------------------------TLQDASTGITKKIHRVMQMLMGVKSELADQQQ 557
             ..:||.|                         |.:||...:..:..:       :..||:..:.
Worm   486 PSAKERRSSSRPKRRETQYRPSPARMALFAEVETSEDAVLDLQCQNEK-------LSCELSSLKD 543

  Fly   558 EHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNNM- 621
            :|:.......|..|.|..|:...:        ||. |::::....:|.:.|...:.|  |.||:
Worm   544 KHEEATSKSIETERLLQGEIVALQ--------KEV-SIVSESLRKSEAVAEGYKEKV--TANNLT 597

  Fly   622 -----------RKHISAHKTSGKEPD 636
                       ||.|:..:.|.||.:
Worm   598 LDKLLLHIDASRKRIAELELSSKESE 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	133/316 (42%)
		Kinesin	26..352	CDD:278646	133/316 (42%)
		RILP-like	<437..556	CDD:304877	34/180 (19%)
klp-18	NP_501093.1	KISc	5..328	CDD:276812	133/314 (42%)
klp-18	NP_501093.1	SbcC	342..913	CDD:223496	61/327 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810