Protein Alignment Klp64D and unc-104

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001022041.2
• Gene: unc-104 / 174144
• WormBaseID: WBGene00006831
• Length: 1628
• Species: Caenorhabditis elegans
• Alignment Length: 664
• Identity: 215/664 - (32%)
• Similarity: 317/664 - (47%)
• Gaps: 106/664 - (15%)

  Fly    18 IENVRVVVRTRPMDKNELSAGALSAISVDKINRAI---TVMKPNATANEPPKTYYFDNVFDGGSN 79
            :.:|:|.||.||.::.|:|..:...:.|:.....|   ::.|.|.:.|.....:.|.........
 Worm     1 MSSVKVAVRVRPFNQREISNTSKCVLQVNGNTTTINGHSINKENFSFNFDHSYWSFARNDPHFIT 65

  Fly    80 QMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKA 144
            |..:|.:....:::...||||..|.||||||:||:|||.|..:.|...||||.....:|..|...
 Worm    66 QKQVYEELGVEMLEHAFEGYNVCIFAYGQTGSGKSYTMMGKANDPDEMGIIPRLCNDLFARIDNN 130

  Fly   145 KENQ-KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRL 208
            .:.. ::.|.|||||||.|.|:|||..:.|.:|.|:|.|.:|.:|.||:...|.:..|:.|:|..
 Worm   131 NDKDVQYSVEVSYMEIYCERVKDLLNPNSGGNLRVREHPLLGPYVDDLTKMAVCSYHDICNLMDE 195

  Fly   209 GNKNRAVGATKMNQESSRSHAIFSITV-ERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQ 272
            |||.|.|.||.||..||||||:|:|.: ::....:.::...:..|:.|||||||||.:.|.|.||
 Worm   196 GNKARTVAATNMNSTSSRSHAVFTIVLTQKRHCADSNLDTEKHSKISLVDLAGSERANSTGAEGQ 260

  Fly   273 RLKEATKINLSLSVLGNVISALVDGKSTH--------IPYRNSKLTRLLQDSLGGNSKTVMCATI 329
            ||||...||.||:.||.|||.|.: :||.        ||||:|.||.||:::|||||||.|.|.:
 Worm   261 RLKEGANINKSLTTLGLVISKLAE-ESTKKKKSNKGVIPYRDSVLTWLLRENLGGNSKTAMLAAL 324

  Fly   330 SPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEG--DSLE-EEP 391
            ||||.|:.||:||||||.|||.|..:..:||:|...|:|...||:.:||..|::.  |..: :|.
 Worm   325 SPADINFDETLSTLRYADRAKQIVCQAVVNEDPNAKLIRELNEEVIKLRHILKDKGIDVTDVQET 389

  Fly   392 PSSEEEEDTADDELEAPLEIELESSTIQA-VEKKPKKKREKTDAEKEELAKRKNEHQKEIEHAKT 455
            |...::.......:...||...||..:.| :.|..::|...|    ||:.|::.|..:::..|..
 Worm   390 PGKHKKGPKLPAHVHEQLEKLQESEKLMAEIGKTWEQKLIHT----EEIRKQREEELRDMGLACA 450

  Fly   456 EQETLRN--------KLVSL---------------EG-------------KILVGGENLLE---- 480
            |..|...        .||:|               ||             .||:.||.:||
 Worm   451 EDGTTLGVFSPKKLPHLVNLNEDPLMSECLIYYLKEGVTSVGRPEAEHRPDILLSGEAILELHCE 515

  Fly   481 -----------------------KAQTQELLLEQSIAELEQH-----EKSEEALKQTLQQKATER 517
                                   :..|..:|...|...|.:|     ...:||.:......|...
 Worm   516 FINEDGNVTLTMKPNASCYINGKQVTTPTVLHTGSRVILGEHHVFRYNDPQEARQSRHNLAAIAE 580

  Fly   518 IDIEERYSTLQ-------DASTGITKKIHRVMQMLMGVKSELADQQQEHQ-REKEGIYENIRSLS 574
            ..|:.:|:..:       |....:.||:..:.......|.|| :|:..|| ||.|.:.||   |.
 Worm   581 QPIDWKYAQQELLDKQGIDLKADMEKKMLEMESQYRREKVEL-EQKMYHQTREYESMIEN---LQ 641

  Fly   575 RELALCELVLNSYV 588
            :::.|.:    ||:
 Worm   642 KQVDLAQ----SYI 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	147/345 (43%)
		Smc	<433..>578	CDD:440809	43/220 (20%)
unc-104	NP_001022041.2	KISc_KIF1A_KIF1B	2..354	CDD:276816	148/352 (42%)
		Kinesin_assoc	351..488	CDD:465047	32/140 (23%)
		FHA_KIF1	464..564	CDD:438757	16/99 (16%)
		Rcc_KIF21	595..652	CDD:425381	18/65 (28%)
		KIF1B	829..875	CDD:463574
		DUF3694	1116..1260	CDD:463599
		PH_KIFIA_KIFIB	1500..1602	CDD:269939