DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp64D and Kif7

DIOPT Version :10

Sequence 1:NP_523934.1 Gene:Klp64D / 38611 FlyBaseID:FBgn0004380 Length:677 Species:Drosophila melanogaster
Sequence 2:NP_001278151.1 Gene:Kif7 / 16576 MGIID:1098239 Length:1348 Species:Mus musculus


Alignment Length:657 Identity:211/657 - (32%)
Similarity:315/657 - (47%) Gaps:115/657 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 VRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDLYV 85
            |||.:|.||:...||..|..|.:.|:.....||:.:        .:.:.|..|....:.|..:|.
Mouse    16 VRVALRVRPLLPKELLHGHQSCLRVEPERGRITLGR--------DRHFGFHVVLGEDTGQEAVYQ 72

  Fly    86 DTARPIVDKVLEGYNGTILAYGQTGTGKTYTM------SGNPDSPQTKGIIPNAFAHIFGHIAKA 144
            ...:|:::...||:|.|:.||||||:||||||      |.:.|.   :||||.|.|..|..|   
Mouse    73 ACVQPLLEAFFEGFNATVFAYGQTGSGKTYTMGEASVASLHEDE---QGIIPRAMAEAFKLI--- 131

  Fly   145 KENQKF--LVRVSYMEIYNEEVRDLLGKDVG-KSLEVKERPD-------IGVFVKDLSGYVVHNA 199
            .||...  ||.|||:|:|.||.||||  :|| .|.:::.|.|       .||...|:.|     .
Mouse   132 DENDLLDCLVHVSYLELYKEEFRDLL--EVGTASRDIQLREDDRGNVVLCGVKEVDVEG-----L 189

  Fly   200 DDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVER-----SELGEGDVQHVRMGKLQLVDLA 259
            |::.:::.:||..|..|||..|:.|||||.:|::|:|:     |.|......|:.:.|...||||
Mouse   190 DEVLSLLEMGNAARHTGATHFNRLSSRSHTVFTVTLEQRGRTPSRLPRPAAGHLLVSKFHFVDLA 254

  Fly   260 GSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD--GKSTHIPYRNSKLTRLLQDSLGGNSK 322
            ||||..||.::|:||||:.:||.:|..||||||||.|  .:.:|||||:||:||:|:||||||:|
Mouse   255 GSERVLKTGSTGERLKESIQINSTLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLGGNAK 319

  Fly   323 TVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSL 387
            |||.|.:||:.|::.||::||.|||||:||:||..:|..|          |..|:.::...|   
Mouse   320 TVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVNWRP----------EAERVPEEQAAG--- 371

  Fly   388 EEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTDAEKEELAKRKNEHQKEIEH 452
            ...||....|..........|......::....:..:..:.|.:|.|....|    .|.|.|...
Mouse   372 ARGPPRHRSETRIIHRGRRVPCPAVGSAAVAAGLGAECARCRARTSAAYSLL----RELQAEPGL 432

  Fly   453 AKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHE-----KSEEALKQTLQ- 511
            .......:|:.|.::||:     .:.|..|...:..:|.:.||.:..:     |.:|..:|.|. 
Mouse   433 PGAAARKVRDWLCAVEGE-----RSTLSSASGPDSGIESAPAEDQAAQGTSGRKGDEGTQQLLTL 492

  Fly   512 QKATERIDIEER--YSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLS 574
            |....|::.|.|  .:.|:||           |:........|.:||:|....:         |.
Mouse   493 QSQVARLEEENRDFLAALEDA-----------MEQYKLQSDRLREQQEEMVELR---------LR 537

  Fly   575 RELA---------LCELVLNSYVPKEYQSMI-NQYTHWNEDIGEWQLKCVAYTGNNMRKHISAHK 629
            .|||         |..|...|:||:.:.:.: ..:||.   :|.....|:.      .:.:|:.:
Mouse   538 LELAQPGWGAPGLLQGLPPGSFVPRPHTAPLGGAHTHM---LGMMPSTCLP------GEEVSSEQ 593

  Fly   630 --TSGKE 634
              .||||
Mouse   594 QVVSGKE 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp64DNP_523934.1 KISc_KIF3 19..352 CDD:276822 148/353 (42%)
Smc <433..>578 CDD:440809 32/152 (21%)
Kif7NP_001278151.1 KISc_KIF4 15..350 CDD:276823 149/354 (42%)
Interaction with SMO. /evidence=ECO:0000269|PubMed:25644602 358..1211 58/294 (20%)
Interaction with DLG5. /evidence=ECO:0000269|PubMed:25644602 358..479 24/142 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..486 7/34 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..674
Smc <707..>1203 CDD:440809
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1314
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1328..1348
Blue background indicates that the domain is not in the aligned region.

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