Protein Alignment Klp64D and Kif5b

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_032474.2
• Gene: Kif5b / 16573
• MGIID: 1098268
• Length: 963
• Species: Mus musculus
• Alignment Length: 731
• Identity: 235/731 - (32%)
• Similarity: 341/731 - (46%)
• Gaps: 159/731 - (21%)

  Fly    20 NVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDLY 84
            |::|:.|.||::::|::.|..   .|.|.....|||    .|::|   |.||.||...::|..:|
Mouse     8 NIKVMCRFRPLNESEVNRGDK---YVAKFQGEDTVM----IASKP---YAFDRVFQSSTSQEQVY 62

  Fly    85 VDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQK 149
            .|.|:.||..|||||||||.|||||.:|||:||.|....|:..||||.....||.:|....||.:
Mouse    63 NDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLE 127

  Fly   150 FLVRVSYMEIYNEEVRDLLGKDVGK-SLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            |.::|||.|||.:::||||  ||.| :|.|.|..:...:||..:...|.:.|::.:.:..|..||
Mouse   128 FHIKVSYFEIYLDKIRDLL--DVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNR 190

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEAT 278
            .|..|.||:.|||||:||.|.|::...   ..:....|||.||||||||:.|||.|.|..|.||.
Mouse   191 HVAVTNMNEHSSRSHSIFLINVKQENT---QTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAK 252

  Fly   279 KINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTL 343
            .||.|||.||||||||.:| ||::|||:||:||:||||||||.:|.:....||:..|..||.|||
Mouse   253 NINKSLSALGNVISALAEG-STYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTL 316

  Fly   344 RYASRAKNIQNRMHIN--------------EEPKDALLRH----FQEEIARLRKQLEEGDSLEEE 390
            .:..|||.|:|.:.:|              |:.|:..||:    .:.|:.|.|    .|:::
Mouse   317 LFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWR----NGETV--- 374

  Fly   391 PPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPK----KKREKTDAEK----EELAK------ 441
             |..|:     .|:.:|.||.......|.....||.    .....||||:    |||||
Mouse   375 -PIDEQ-----FDKEKANLEAFTADKDIAITSDKPAAAVGMAGSFTDAERRKCEEELAKLYKQLD 433

  Fly   442 ----RKNEHQKEIEHAKT--------------EQETLRNKLVSLEGKILVGGENLLEKAQTQELL 488
                ..|:..:.:|..||              :|:.::.:|..|:      .||...|.:.:|:|
Mouse   434 DKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQ------AENDASKEEVKEVL 492

  Fly   489 ---------LEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKKIHRVMQM 544
                     .:|...|:|...|..|.|...|.||:.....|:.....|::.:....|:...:|..
Mouse   493 QALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMAS 557

  Fly   545 LM------GV------------------------------KSE----------LADQQQEHQREK 563
            |:      |:                              |||          |...|.|..::.
Mouse   558 LLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKM 622

  Fly   564 EGIYENIRSLSRELALCELVLNSYVPK-----EYQSMINQYTHWNED----IGE--WQLKCVAYT 617
            |   ||    .:|||.|:|.::.:..|     ||...:.|.....|:    :||  .||:.....
Mouse   623 E---EN----EKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLGEELVQLRAQEKV 680

  Fly   618 GNNMRKHISAHKTSGK 633
            ....::|::..:|:.:
Mouse   681 HEMEKEHLNKVQTANE 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	154/332 (46%)
		Smc	<433..>578	CDD:440809	45/227 (20%)
Kif5b	NP_032474.2	KISc_KHC_KIF5	6..325	CDD:276820	154/332 (46%)
		SMC_prok_B	<417..803	CDD:274008	58/293 (20%)
		Khc_CBD_cc	834..903	CDD:467880
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963
		Globular	915..963