DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Kif3c

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_032471.2	Gene:	Kif3c / 16570	MGIID:	107979	Length:	796	Species:	Mus musculus

Alignment Length:	771	Identity:	304/771 - (39%)
Similarity:	443/771 - (57%)	Gaps:	116/771 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |.::||.|.||:.:.|.:||....:::|.....:|:..|.|...|.|||:.||.|:|..|.|.||
Mouse     9 EALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADL 73

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |.:|.||::|.||:|:|||:.|||||||||||||.|....|:.:|:|||||.|||.||::: :||
Mouse    74 YDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRS-QNQ 137

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            ::|||.||:|||.||:||||.|:.||.||:||.|:.||::||||.:|..|..::|::|.|||:.|
Mouse   138 QYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQAR 202

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSK----------TQ 268
            |||:|.||:.||||||||.||||.||.|.....|:|:|||.||||||||||:|          ||
Mouse   203 AVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNAAGGPATQ 267

  Fly   269 ----------------ASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSL 317
                            :||:|.|||:|||||||.|||||:||...:|||||||:|||||||||||
Mouse   268 PTAGGGSGSGSASGSASSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSL 332

  Fly   318 GGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLE 382
            |||:||:|.||:.||..:|.|::||||:|:|||||:|:..:||:|||.|||.||||||||:.|||
Mouse   333 GGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLE 397

  Fly   383 EGDSLEEEP-------------PS------------SEEEEDTADDE------LEAPLEIELESS 416
            :...|.:.|             |:            :|||:|..::.      |||.||..:|:.
Mouse   398 KKGMLGKRPRRKSSRRKKAVSAPAGYPEGSVIEAWVAEEEDDNNNNHHPPQPILEAALEKNMENY 462

  Fly   417 TIQAVEKKPKKK------REKTDAEKEELAKRKNEHQKEIEHAKTEQETLRNKLVSLEGKILVGG 475
            .....|:..::|      |.....||::|.:.|.:..:::...:...|.|..|..::|.|:|:||
Mouse   463 LQDQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESKLLIGG 527

  Fly   476 ENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKKIHR 540
            .|:::....|:.:||....|:.:.::.|..::|.:..:..|.:::...||:||......|||:.:
Mouse   528 RNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTYSSLQQEVEVKTKKLKK 592

  Fly   541 VMQMLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNED 605
            :...|..||:|:.||.:|:.|.::.:.|.....:|||.|..|::.:::|.|.::.|......:.:
Mouse   593 LYAKLQAVKAEIQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLFLDCE 657

  Fly   606 IGEWQLKCVAYTGNN---MRKH----------ISAH----KTSGKEPDF---------LDLSH-- 642
            ..:|:.:.:...|.|   |:|.          ||.:    ...|..|.:         ||:|.
Mouse   658 EEQWRFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVSPPA 722

  Fly   643 -VYLSYNTDGVSNP--------MRSKS--ARPRTSGV-------------PRPTTA 674
             ..:.::.|...:|        ||..|  .||.|:.|             |.|:||
Mouse   723 IFEMEFSHDQEQDPRVLHMERLMRLDSFLERPSTTKVRKSRSWCQSPQRMPPPSTA 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	197/358 (55%)
		Kinesin	26..352	CDD:278646	194/351 (55%)
		RILP-like	<437..556	CDD:304877	30/118 (25%)
Kif3c	NP_032471.2	KISc_KIF3	9..367	CDD:276822	197/358 (55%)
		Kinesin	16..367	CDD:278646	194/351 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..292		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422		4/24 (17%)
		GBP_C	<463..571	CDD:303769	23/107 (21%)
		coiled coil	540..551	CDD:293879	3/10 (30%)
		coiled coil	560..571	CDD:293879	2/10 (20%)
		Globular. /evidence=ECO:0000255	633..793		29/146 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..796		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720