DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Kif3b

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_032470.3	Gene:	Kif3b / 16569	MGIID:	107688	Length:	747	Species:	Mus musculus

Alignment Length:	639	Identity:	302/639 - (47%)
Similarity:	424/639 - (66%)	Gaps:	44/639 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |:||||||.|||:..|.:|.....:.||.....::|..|..|::|.|||:.||.|:|..:.|.:|
Mouse     8 ESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTSHEMPKTFTFDAVYDWNAKQFEL 72

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |.:|.||:||.||:|:||||.|||||||||||||.|....|:.:|:|||:|.|||.||::: :||
Mouse    73 YDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVRGDPEKRGVIPNSFDHIFTHISRS-QNQ 136

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            ::|||.||:|||.||:||||.||..|.||:|||||.||:|||||.:|..:..::|::|.:||:||
Mouse   137 QYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNR 201

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEAT 278
            :||||.||:.||||||||.||:|.||:|.....|:|:|||.||||||||||:||.|.|:||||||
Mouse   202 SVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEAT 266

  Fly   279 KINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTL 343
            |||||||.|||||||||||||||||||:||||||||||||||:||||.|.:.||..|..||::||
Mouse   267 KINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTL 331

  Fly   344 RYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEE---------------------GDSL 387
            |||:|||||:|:..:||:|||||||.||||||||:.|||:                     |:..
Mouse   332 RYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEE 396

  Fly   388 EEEPPSSEEEEDTADD---ELEAPLEIE----LESSTIQAVEKKPKKKREKTDAEKEELAKRKNE 445
            |||....||:.|..||   |.:..||||    :|..::.|             .||..|.|.|.:
Mouse   397 EEEGEEGEEDGDDKDDYWREQQEKLEIEKRAIVEDHSLVA-------------EEKMRLLKEKEK 448

  Fly   446 HQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTL 510
            ..:::...|...|.|..|:.::|.|:||||:|:::....|:.:|||...|:.:.::.|..::|.:
Mouse   449 KMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQM 513

  Fly   511 QQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENIRSLSR 575
            :.:..|.::::|.|::||......|||:.::...|..||:|:.|.|:||.:|::.:.:....|:|
Mouse   514 ESRDEETLELKETYTSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTR 578

  Fly   576 ELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNN--MRKHISA 627
            ||.|..|::.:::|.|.::.|...:.::::...|:|..:....|.  |::.:||
Mouse   579 ELKLKHLIIENFIPLEEKNKIMNRSFFDDEEDHWKLHPITRLENQQMMKRPVSA 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	208/332 (63%)
		Kinesin	26..352	CDD:278646	202/325 (62%)
		RILP-like	<437..556	CDD:304877	34/118 (29%)
Kif3b	NP_032470.3	KISc_KIF3	8..340	CDD:276822	208/332 (63%)
		Kinesin	15..340	CDD:278646	202/325 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..412		7/37 (19%)
		Globular	580..747		12/53 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..747
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710