Protein Alignment Klp64D and Kif3a

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Alignment Length: 707
• Identity: 397/707 - (56%)
• Similarity: 504/707 - (71%)
• Gaps: 52/707 - (7%)

  Fly    16 DEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQ 80
            :..:||:||||.||:::.|.|.....|:|||::...|||.|.: ::||||||:.||.||...|.|
Mouse    10 ESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTD-SSNEPPKTFTFDTVFGPESKQ 73

  Fly    81 MDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAK 145
            :|:|..|||||:|.|||||||||.||||||||||:||.|....|..:|:|||:|||||||||||:
Mouse    74 LDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAE 138

  Fly   146 ENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGN 210
            .:.:|||||||:||||||||||||||..:.||||||||:||::||||.|||:||||::.||.||:
Mouse   139 GDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGH 203

  Fly   211 KNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLK 275
            |||:||||.||:.||||||||:||:|.||.|.....|||||||.||||||||||:||.|:|||||
Mouse   204 KNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLK 268

  Fly   276 EATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETI 340
            ||||||||||.|||||||||||||||:|||||||||||||||||||||:|||.|.|||.||.|||
Mouse   269 EATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETI 333

  Fly   341 STLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEEPPSSEEEED------ 399
            ||||||:|||||:|:..|||:|||||||.||:||..|:|:||||:.:.....|..||:|
Mouse   334 STLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDEEGELG 398

  Fly   400 ---------------TADDE----LEAPLE-----------------IELESSTIQAVEKKPKKK 428
                           ::.|.    :|.||:                 :|:::.    ::::.|..
Mouse   399 EDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLPHQAGKKKVSPDKMVEMQAK----IDEERKAL 459

  Fly   429 REKTDAEKEELAKRKNE---HQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLE 490
            ..|.|.|:||..|.:.|   .:|::..|:.|.::|..||.:||.|::|||.:||.||:.||.|||
Mouse   460 ETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLE 524

  Fly   491 QSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQ 555
            :|..|||:..:..|.|::.|::|..||:||||:|::||:.:.|.|||:.:|..|||..|||:||.
Mouse   525 ESNMELEERRRRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADL 589

  Fly   556 QQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNN 620
            |||||||.||:.||||.|||||.|..|::::::|::||.||..|.||||||||||||||||||||
Mouse   590 QQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNN 654

  Fly   621 MRKHISAHKTSGKEPDFLDLSHVYLSYNTDGVSNPMRSKSARPRTS-GVPRPTTARR 676
            |||.........::|..:|||||||:|..:.:...: .|..||||| |..||...||
Mouse   655 MRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSL-MKLERPRTSKGKARPKMGRR 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	237/332 (71%)
		Smc	<433..>578	CDD:440809	74/147 (50%)
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	237/332 (71%)
		Smc	<450..>614	CDD:440809	77/167 (46%)