Protein Alignment Klp64D and Kif21a

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_017171930.1
• Gene: Kif21a / 16564
• MGIID: 109188
• Length: 1685
• Species: Mus musculus
• Alignment Length: 697
• Identity: 204/697 - (29%)
• Similarity: 325/697 - (46%)
• Gaps: 154/697 - (22%)

  Fly    26 RTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEP------PKTYYFDNVFDGGSNQMDLY 84
            |.||....|...|.....||              |..||      .|.:.||.|||..|.|..:|
Mouse    23 RIRPQLAKEKIEGCHICTSV--------------TPGEPQVFLGKDKAFTFDYVFDIDSQQEQIY 73

  Fly    85 VDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPD---SPQTKGIIPNAFAHIFGHIAKAKE 146
            ......:::...||||.|:.||||||.||||||....|   ..:.:|||..|..|:|..|.:.|.
Mouse    74 TQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIMEEEQGIISRAVRHLFKSIDEKKT 138

  Fly   147 N--------QKFLVRVSYMEIYNEEV-------RDLLGKDVGKSLEVKERPDIGVFVKDLSGYVV 196
            :        .:|.|...::|:|||||       ||:..|:...::.:.|....|::...::...|
Mouse   139 SAIKNGLPPPEFKVNAQFLELYNEEVLDLFDTTRDIDAKNKKSNIRIHEDSTGGIYTVGVTTRTV 203

  Fly   197 HNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITV---------------------ERSEL 240
            :...::...::||..:|...:|:||.:||||||||:|.|                     |.|.:
Mouse   204 NTEPEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQTDAENATDNKLISESSPM 268

  Fly   241 GEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD--GKSTHIP 303
            .|.:   ....|...||||||||..:|.|:|:|.||...||..|..||||||||.|  .::||:|
Mouse   269 NEFE---TLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVP 330

  Fly   304 YRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLR 368
            ||:|||||||||||||||:|:|.|.:||:|.::|||::||:||:||:||:|::.:|::.....:.
Mouse   331 YRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQIN 395

  Fly   369 HFQEEIARLRKQLEE---GDSLEEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKRE 430
            ..:.||.||:.:|.|   |..:.:     ||..::.:|.......::.|::.::.   :.|..:|
Mouse   396 ALRSEITRLQMELMEYKTGKRIID-----EEGVESINDMFHENAMLQTENNNLRV---RIKAMQE 452

  Fly   431 KTDA-----------EKEELAKRKNEHQKEIE---HAKTEQ-ETLRNKLVSLEGKILVGGENL-- 478
            ..||           :..::..|..|..:||.   |:..:: |.||.||:..|..    .|||
Mouse   453 TVDALRARITQLVSEQANQVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAV----NENLRK 513

  Fly   479 -LEKA----------------------QTQEL--LLEQSIAELEQHEKSEEALKQTLQQKATERI 518
             |.:|                      :|.|:  |.::.:.:|::.||.::...|.|::...|..
Mouse   514 NLTRATARSPYFSASSAFSPTILSSDKETIEIIDLAKKDLEKLKRKEKKKKKRLQKLEESGREER 578

  Fly   519 DI---EERYSTLQD--ASTGITKKIHRVMQMLMGVKSELADQQQEHQREK--------EGIYENI 570
            .:   ::...|.|:  ...|:::|.:.  ::.:....|::|.:.|.:.|:        ||...:.
Mouse   579 SVAGKDDNADTDQEKKEEKGVSEKENN--ELDVEENQEVSDHEDEEEEEEDEEEEDDIEGEESSD 641

  Fly   571 RSLSR---------ELA--LCELVLNSYV-------PKEYQSMINQY 599
            .|.|.         :||  .||:.:...:       .|..|::..||
Mouse   642 ESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQY 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	140/372 (38%)
		Smc	<433..>578	CDD:440809	39/208 (19%)
Kif21a	XP_017171930.1	KISc_KIF4	23..380	CDD:276823	141/373 (38%)
		Cast	<372..846	CDD:431111	68/331 (21%)
		EnvC	650..>865	CDD:443969	8/39 (21%)
		Rcc_KIF21A	946..1027	CDD:410204
		WD40	1350..1663	CDD:238121
		WD40 repeat	1401..1460	CDD:293791
		WD40 repeat	1466..1501	CDD:293791
		WD40 repeat	1506..1550	CDD:293791
		WD40 repeat	1558..1591	CDD:293791
		WD40 repeat	1598..1634	CDD:293791