DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp64D and Kif1b

DIOPT Version :10

Sequence 1:NP_523934.1 Gene:Klp64D / 38611 FlyBaseID:FBgn0004380 Length:677 Species:Drosophila melanogaster
Sequence 2:NP_001277924.1 Gene:Kif1b / 16561 MGIID:108426 Length:1816 Species:Mus musculus


Alignment Length:823 Identity:239/823 - (29%)
Similarity:352/823 - (42%) Gaps:224/823 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 NVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATA-------NEPPKTYYFDNVFDGG 77
            :|:|.||.||.:..|.|          |.::.|..|:.|:|:       .|.||::.||..:...
Mouse     5 SVKVAVRVRPFNSRETS----------KESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSH 59

  Fly    78 SNQMD--------LYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAF 134
            ::..|        :|.|..:.::....||||..|.||||||.||:|||.|..:..|. ||||...
Mouse    60 TSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQA-GIIPQLC 123

  Fly   135 AHIFGHI-AKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHN 198
            ..:|..| ....|...:.|.|||||||.|.|||||......:|.|:|.|.:|.:|:|||...|.:
Mouse   124 EELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTS 188

  Fly   199 ADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSIT-VERSELGEGDVQHVRMGKLQLVDLAGSE 262
            ..|:.::|..|||.|.|.||.||:.||||||:|:|. .::.:..|.::...::.|:.||||||||
Mouse   189 YTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSE 253

  Fly   263 RQSKTQASGQRLKEATKINLSLSVLGNVISAL--VDG---------KSTHIPYRNSKLTRLLQDS 316
            |...|.|.|.||||...||.||:.||.|||||  ||.         |:..||||:|.||.||:::
Mouse   254 RADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLREN 318

  Fly   317 LGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQL 381
            |||||:|.|.|.:||||.||.||:||||||.|||.|:....|||:|...|:|..:||:.||:..|
Mouse   319 LGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLL 383

  Fly   382 EE---GDSLEEEP---------------------------------------------------- 391
            ..   ||.::.:|                                                    
Mouse   384 RAQGLGDIIDIDPLIDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSL 448

  Fly   392 -------------------PSSEE------EEDTADDELEAPLEIELESSTIQAVEKK------- 424
                               |..||      |.:....||....|.:|..:....:|::       
Mouse   449 NSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMG 513

  Fly   425 --------------PKK--------------------------KREKTDAEKEELAKRKNEHQKE 449
                          |||                          :..:.|||:.:.......|.||
Mouse   514 VAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKE 578

  Fly   450 IEHA--KTEQETLRNKLVSLE----GKILVGGENLLEKAQTQ---ELLL-----------EQSIA 494
             ||.  ::|:......:|:||    .:..|.|:.:....|.:   .:::           ||:.|
Mouse   579 -EHCLFRSERSNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFNHPEQARA 642

  Fly   495 ELEQHEKSE---EALKQTLQQK---ATERIDI-EERYSTLQDASTGITKKIHRVMQMLMGVKSEL 552
            |.|:...:|   |.:..|..|:   ..:.||: :|....||:            |::|...:.|.
Mouse   643 EREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQE------------MEILYKKEKEE 695

  Fly   553 ADQQQEHQREKEGIYEN-IRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAY 616
            ||...|.||..   ||: :::|.|::....|...:...:|.:..: .:|....::.:|.      
Mouse   696 ADLLLEQQRLD---YESKLQALQRQVETRSLAAETTEEEEEEEEV-PWTQHEFELAQWA------ 750

  Fly   617 TGNNMRKHISAHKTSGKEPDFLDLSHVYLSYNTDGVSNPMRSK 659
                .||..|...||.:  |.|..:.|||. ..:.:|..::.|
Mouse   751 ----FRKWKSHQFTSLR--DLLWGNAVYLK-EANAISVELKKK 786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp64DNP_523934.1 KISc_KIF3 19..352 CDD:276822 155/359 (43%)
Smc <433..>578 CDD:440809 41/172 (24%)
Kif1bNP_001277924.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 156/366 (43%)
Interaction with KIFBP. /evidence=ECO:0000250|UniProtKB:O60333 270..350 45/79 (57%)
Kinesin_assoc 358..555 CDD:465047 26/196 (13%)
FHA_KIF1B 530..639 CDD:438779 16/109 (15%)
GimC 662..>719 CDD:440992 18/71 (25%)
KIF1B 845..892 CDD:463574
KIF1B <956..975 CDD:463574
DUF3694 1266..1413 CDD:463599
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1522..1571
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1620..1659
PH_KIFIA_KIFIB 1701..1799 CDD:269939
Blue background indicates that the domain is not in the aligned region.

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