DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp64D and Kif17

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_034753.1	Gene:	Kif17 / 16559	MGIID:	1098229	Length:	1038	Species:	Mus musculus

Alignment Length:	628	Identity:	269/628 - (42%)
Similarity:	359/628 - (57%)	Gaps:	104/628 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDL 83
            |:|:||||.|||:|.|......|.::||.......:..|.| |:||||.:.||..:........:
Mouse     4 ESVKVVVRCRPMNKRERELSCQSVVTVDSARGQCFIQNPGA-ADEPPKQFTFDGAYYIEHFTEQI 67

  Fly    84 YVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQ 148
            |.:.|.|:|:.|.|||||||.||||||:||::||.|.||.|..:||||.||.|:|..: :..||.
Mouse    68 YNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPCQRGIIPRAFEHVFESV-QCAENT 131

  Fly   149 KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNR 213
            |||||.||:|||||:|.||||.|..:.||:||.|:.||:||.||.:.|||....|.:|..|.|||
Mouse   132 KFLVRASYLEIYNEDVHDLLGADTKQRLELKEHPEKGVYVKGLSMHTVHNVAQCERVMETGWKNR 196

  Fly   214 AVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEAT 278
            |||.|.||::|||||:||:|.:|...:.|....|:|.|||.|||||||||||||.|:|:||||||
Mouse   197 AVGYTLMNKDSSRSHSIFTINIEIYAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLKEAT 261

  Fly   279 KINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTL 343
            |||||||.|||||||||||:..|||||:||||||||||||||:||:|.|.:||||:||.||:|||
Mouse   262 KINLSLSALGNVISALVDGRCKHIPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTL 326

  Fly   344 RYASRAKNIQNRMHINEEPKDALLRHFQEEIARLR----KQLEEGDSLEEEPPSSEEEEDTADDE 404
            |||:|||||:|:..|||:|||||||.:||||.||:    :|:..|:
Mouse   327 RYANRAKNIKNKPRINEDPKDALLREYQEEIKRLKAILAQQMGPGN------------------- 372

  Fly   405 LEAPLEIELESSTIQAVEK--KPKKKREKTDAEK--------EELAKRKNEHQKEIEHAKTEQET 459
            |.|.|..:.....:|:.||  .|...::.|:|||        |.||:.|.:::.|.|.....||.
Mouse   373 LSALLSTQTPPGPVQSEEKLLSPTTVQQDTEAEKQLIREEYEERLARLKADYEAEQESRVRLQED 437

  Fly   460 LRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKS--------------EEALKQTL 510
            :.....|.:.|:....|||.::.:|:.:|..:.:.:.|...::              |.|:|.|:
Mouse   438 ITAMRNSYDVKLSTLQENLRKEKETEAILKAEVLCKTEVMSRAELASGPEYSPPLQYETAVKPTI 502

  Fly   511 QQ-----------KATERIDIEERY---------------STLQDASTGITKKIHRVMQMLMGVK 549
            ..           |:...:..||.:               |||:|::|
Mouse   503 LSMPDMPPSGKVTKSQAPLAFEEPHGETSRSEFSFESNECSTLEDSAT----------------- 550

  Fly   550 SELADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEY 592
            ||.....:|        :.|: ..|...||.|   :.|:|:||
Mouse   551 SEAFPGPEE--------FSNM-EFSMAAALTE---SRYLPEEY 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	197/332 (59%)
		Kinesin	26..352	CDD:278646	192/325 (59%)
		RILP-like	<437..556	CDD:304877	30/158 (19%)
Kif17	NP_034753.1	Motor_domain	4..335	CDD:277568	197/332 (59%)
		Kinesin	11..335	CDD:278646	192/325 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..401		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..559		10/72 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..657
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	916..940
		AC_N	918..>1036	CDD:292831
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	976..1038
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920