Protein Alignment Klp64D and Kif16b

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_036014693.1
• Gene: Kif16b / 16558
• MGIID: 1098240
• Length: 1908
• Species: Mus musculus
• Alignment Length: 812
• Identity: 246/812 - (30%)
• Similarity: 352/812 - (43%)
• Gaps: 228/812 - (28%)

  Fly    11 TAQLDDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMK-PNA----TANEPPKTYYF 70
            |.:|:..:|.:..|     :...|....|...|.::|....||.:| |..    :..|..||:.:
Mouse    33 TTELEKWVEILAAV-----LFSGEKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTY 92

  Fly    71 DNVFDGGSNQMDLYVD-------TARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNP-DSPQTK 127
            |..|.....:...||.       ....:|....||||..:.||||||:||:|||.||. ||
Mouse    93 DFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDS---- 153

  Fly   128 GIIPNAFAHIFGHIAKAK--ENQKFLVRVSYMEIYNEEVRDLLGKDVGK--SLEVKERPDIGVFV 188
            |:||.....:|..|.:..  :...|...|||:|||||.|||||.:...|  :|.|:|.|..|.:|
Mouse   154 GLIPRICEALFSRINETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYV 218

  Fly   189 KDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKL 253
            :|||.::|.|..|:|.:|..||.||...||.||..||||||||:|...:::. :.::....:.|:
Mouse   219 EDLSKHLVQNYSDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKF-DAEMPCETVSKI 282

  Fly   254 QLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVD-----------GKSTHIPYRNS 307
            .|||||||||...|.|:|.||||...||.||..||||||||.|           .|...:|||:|
Mouse   283 HLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANPLVKKKQVFVPYRDS 347

  Fly   308 KLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQE 372
            .||.||:|||||||||:|.|||||||.||.||:||||||:|||||.|:..|||:....|:|..:.
Mouse   348 VLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRA 412

  Fly   373 EIARLRKQLEEGD--SLEEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTD-- 433
            |||||:..|.:|:  :|.:.|.:...||....:|           :.:|.:.|:...|..:|.
Mouse   413 EIARLKTLLAQGNQIALLDSPTALSMEEKLHQNE-----------ARVQELTKEWTNKWNETQNI 466

  Fly   434 AEKEELAKRKN---------------------------EHQKE------IEHAKTEQE------- 458
            .:::.||.||.                           .|.||      .|.|.|||:
Mouse   467 LKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGREDASTEQDIVLHGLD 531

  Fly   459 ------------------TLRNKLVSLEG-------------KILVGGENL-------------- 478
                              .||....|:.|             .||:|..|:
Mouse   532 LESEHCVFENAGGTVTLIPLRGSQCSVNGVQIVDATQLNQGAVILLGRTNMFRFNHPKEAAKLRE 596

  Fly   479 ----------------------------------------------LEKAQTQELLLEQS----I 493
                                                          .|:.|.:||...:|    |
Mouse   597 KRKSGLLSSFSLSMTDLSKSCENLSAVMLYNPGLFPIKGPICLRLEFERQQREELEKLESKRKLI 661

  Fly   494 AELEQHEKSEEALKQTLQQ------KATERI--DIEERYSTLQDASTGITKKIHRVMQMLMGVKS 550
            .|:|:.:||::|..:.:||      |.||.:  .|.::..:|:..|..|..|:..::......:.
Mouse   662 EEMEEKQKSDKAELERMQQEVETRRKETEIVQRQIRKQEESLKRRSFHIENKLKDLLAEKERFEE 726

  Fly   551 E-LADQQ---QEHQREKEGIY---ENIRSLSRELALCELVLNSYVPKE----YQSMINQYTHWN- 603
            | |.:||   |:.::|:|.::   |.:|.|..        |||:...|    :|.:...:...|
Mouse   727 ERLREQQGLEQQRRQEEESLFRIREELRKLQE--------LNSHEQAEKVQIFQELDRLHQEQNA 783

  Fly   604 ------------EDIGEWQLKCVAYTGNNMRK 623
                        |:..:.|::.||:....:||
Mouse   784 QSAKLRLEKRRLEEEEKEQVQRVAHLEEQLRK 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	157/360 (44%)
		Smc	<433..>578	CDD:440809	51/296 (17%)
Kif16b	XP_036014693.1	KISc_KIF1A_KIF1B	51..399	CDD:276816	158/352 (45%)
		Kinesin_assoc	398..510	CDD:465047	27/122 (22%)
		FHA	480..596	CDD:469597	16/115 (14%)
		Smc	<644..>1118	CDD:440809	43/180 (24%)