Protein Alignment Klp64D and Kif13b

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_006518682.1
• Gene: Kif13b / 16554
• MGIID: 1098265
• Length: 1847
• Species: Mus musculus
• Alignment Length: 705
• Identity: 236/705 - (33%)
• Similarity: 347/705 - (49%)
• Gaps: 156/705 - (22%)

  Fly    21 VRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNAT---ANEPPKTYYFDNVF-------- 74
            |:|.||.|||::.|:.......:.|:.....:..:..|.:   |...||.:.:|:.|
Mouse     6 VKVAVRVRPMNRREIDLHTKCVVDVEANKVILNPVNTNLSKGDARGQPKIFAYDHCFWSMDESVR 70

  Fly    75 DGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFG 139
            :..:.|.|::......|:....:|||..|.||||||:||:|||.|..|.|   |:||...:.:|.
Mouse    71 EKYAGQEDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQP---GLIPRLCSGLFE 132

  Fly   140 HIAKAK-ENQKFLVRVSYMEIYNEEVRDLLG-KDVGKSLEVKERPDIGVFVKDLSGYVVHNADDL 202
            ...|.: |.|.|.|.|||||||||:|||||. |...::|:|:|...:|.:|..||...|.:..|:
Mouse   133 RTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDI 197

  Fly   203 ENIMRLGNKNRAVGATKMNQESSRSHAIFSIT-------VERSELGEGDVQHVRMGKLQLVDLAG 260
            |::|..|||:|.|.||.||:|||||||:|.||       |:....||      ::|||.||||||
Mouse   198 ESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGE------KVGKLSLVDLAG 256

  Fly   261 SERQSKTQASGQRLKEATKINLSLSVLGNVISALVD-----GKSTHIPYRNSKLTRLLQDSLGGN 320
            |||.:||.|:|.||||.:.||.||:.||.|||||.|     .|:..:|||:|.||.||:||||||
Mouse   257 SERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKDSLGGN 321

  Fly   321 SKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGD 385
            |||.|.||:|||..||.||:||||||.|||:|.|...:||:|...::|..:||:.:||:||.:.:
Mouse   322 SKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLREQLTKAE 386

  Fly   386 SLEEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKREKTDAEKEELAKRKNEHQKEI 450
            :::     |.|.:|          .:|.....||.:....::|..||    ||:|:   |.||::
Mouse   387 AMK-----SPELKD----------RLEESEKLIQEMTVTWEEKLRKT----EEIAQ---ERQKQL 429

  Fly   451 EHAKTEQETLRNK-------LVSLE-----GKILV---GGENLLEKAQTQELLL-------EQSI 493
            |......:|...|       ||:|.     .::||   ....|:..|.:|::.|       |..|
Mouse   430 ESLGISLQTSGIKVGDDKCFLVNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHGI 494

  Fly   494 AELEQH-------EKSEEA----------------------------LKQTLQQKATERIDIEER 523
            .::...       :|:...                            |....::|..||.| |:|
Mouse   495 IDITPEGQVVLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAERED-EDR 558

  Fly   524 YSTLQ------------DASTGITKKIH--------RVMQMLMG----VKSELADQQQEHQREKE 564
            .::|:            |:|:.::.:|:        .|....:|    ::|.|:..:|:|:.||.
Mouse   559 EASLKNDSSSEQLDADGDSSSEVSSEINFNFEYAQMEVTMKALGSNDPMQSILSSLEQQHEEEKR 623

  Fly   565 G-------IYEN-----IRSLSRELALCELV--LNSYVPKEYQSMINQYTHWNED 605
            .       :||:     .|.||.|...|..|  |:.:.|...|.:    ..|.|:
Mouse   624 SALERQRLMYEHELEQLRRRLSPERQNCRGVDRLSFHSPSAQQRL----KQWAEE 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	162/355 (46%)
		Smc	<433..>578	CDD:440809	46/237 (19%)
Kif13b	XP_006518682.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	164/362 (45%)
		Kinesin_assoc	357..469	CDD:465047	33/133 (25%)
		FHA_KIF13B	447..545	CDD:438782	13/97 (13%)
		KIF1B	756..802	CDD:463574
		C2-C2_1	<888..>952	CDD:463310
		bMERB_dom	<1073..1143	CDD:463467
		DUF3694	<1220..1277	CDD:463599
		PHA03247	<1423..1659	CDD:223021
		CAP_GLY	1724..1787	CDD:460154