DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp64D and Kif12

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001304281.1	Gene:	Kif12 / 16552	MGIID:	1098232	Length:	643	Species:	Mus musculus

Alignment Length:	458	Identity:	154/458 - (33%)
Similarity:	230/458 - (50%)	Gaps:	47/458 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDLY- 84
            ::||:|.|||...||..|..||:.... .|.:.|        .|...:.|..|.||...|.|::
Mouse    26 IQVVLRVRPMSTVELRRGEQSALHCSG-TRTLQV--------SPDVAFRFGAVLDGARTQEDVFR 81

  Fly    85 VDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDS-------PQTKGIIPNAFAHIFGHIA 142
            ....:.:.:..|.|::.|:..:||||:|||||::|.|..       |...||:...|..:...:.
Mouse    82 ACGVKRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQGEGVPVPPSLAGIMQRTFTWLLDRVQ 146

  Fly   143 KAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMR 207
            ..  :....:|.||:|||||:|.|||.....:.|.|:.....|.:|:.|......:.:.|..:::
Mouse   147 HL--DSPVTLRASYLEIYNEQVWDLLSLGSPRPLPVRWTKARGFYVEQLRVVEFGSLEALMELLQ 209

  Fly   208 LGNKNRAVGATKMNQESSRSHAIFSITVERS--------ELGEGDVQHVRMGKLQLVDLAGSERQ 264
            :|...|...:..:||.||||||:.::.:.|.        :|||..|.    |||..|||||||:.
Mouse   210 MGLSRRRSSSHTLNQASSRSHALLTLHISRPTSQQVPPVDLGEPPVG----GKLCFVDLAGSEKV 270

  Fly   265 SKTQASGQRLKEATKINLSLSVLGNVISALVD--GKSTHIPYRNSKLTRLLQDSLGGNSKTVMCA 327
            :.|.:.||.:.||..||.||..||:.||.|:|  .|..|||:|:||||:||.|||||...|:|.|
Mouse   271 AATGSQGQLMLEANSINRSLLALGHCISLLLDPQRKQNHIPFRDSKLTKLLADSLGGRGVTLMVA 335

  Fly   328 TISPADSNYMETISTLRYASRAKNIQNRMHINEEP--------KDALLRHFQEEIARLRKQLEEG 384
            .:||:.....||:|||||||||:.|..|....:.|        ::.||| .|||...||.||
Mouse   336 CVSPSAQCLPETLSTLRYASRAQRITTRPQGPKSPGVKPPQQVENELLR-LQEENRHLRFQL--- 396

  Fly   385 DSLEEEPPSSEEEEDT-ADDELEAPL-EIELESSTIQAVEKKPKKKREKTDAEKEELAKRKNEHQ 447
            |.:....|.:...... |...|...| |..||:..::...::.:..|:...||:..||::.::.:
Mouse   397 DQMHTTAPGAHGARMAWAQRNLYGMLQEFMLENERLRKEMRQLRSSRDLARAEQRVLAQQVHDLE 461

  Fly   448 KEI 450
            :.:
Mouse   462 RRL 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	128/348 (37%)
		Kinesin	26..352	CDD:278646	126/343 (37%)
		RILP-like	<437..556	CDD:304877	2/14 (14%)
Kif12	NP_001304281.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		KISc	25..358	CDD:276812	127/346 (37%)
		Kinesin	31..360	CDD:278646	126/343 (37%)
		Kinesin-relat_1	<379..464	CDD:289481	23/88 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..562
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..643
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810