Protein Alignment Klp64D and unc-104

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_061509099.1
• Gene: unc-104 / 1275256
• VectorBaseID: AGAMI1_003598
• Length: 1863
• Species: Anopheles gambiae
• Alignment Length: 668
• Identity: 217/668 - (32%)
• Similarity: 321/668 - (48%)
• Gaps: 112/668 - (16%)

  Fly    18 IENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGG----- 77
            :.:|:|.||.||.:..|::..:...|.:......||..|....::|..|.:.:|..:...
Mosquito     1 MSSVKVAVRVRPFNSREIARESKCIIEMAGNTTCITNPKVPPGSSESVKRFNYDYSYWSHDPRDL 65

  Fly    78 --SNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGH 140
              |.|..:|.|....::....:|||..|.||||||.||:|||.|..:..| :|:||.....:|..
Mosquito    66 EFSTQAMVYSDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGKQEDGQ-EGVIPMICKDLFRR 129

  Fly   141 IAKAK-ENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLEN 204
            |.:.: ::.|:.|.|||||||.|.|||||......:|:|:|.|.:|.:|:|||...|.:..|:.:
Mosquito   130 IQETESDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLKVREHPLLGPYVEDLSKLAVTSYQDIHD 194

  Fly   205 IMRLGNKNRAVGATKMNQESSRSHAIFSI--TVERSELGEGDVQHVRMGKLQLVDLAGSERQSKT 267
            ::..|||.|.|.||.||:.||||||:|:|  |.:|.: ....::..::.|:.|||||||||...|
Mosquito   195 LIDEGNKARTVAATNMNETSSRSHAVFTIFFTQKRQD-RMTSLETEKVSKISLVDLAGSERADST 258

  Fly   268 QASGQRLKEATKINLSLSVLGNVISALVD--------GKSTHIPYRNSKLTRLLQDSLGGNSKTV 324
            .|.|.||||...||.||:.||.|||||.:        .|:..||||:|.||.||:::|||||||.
Mosquito   259 GAKGTRLKEGANINKSLTTLGKVISALAEIASKNKKSKKADFIPYRDSVLTWLLRENLGGNSKTA 323

  Fly   325 MCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLE-EGDSLE 388
            |.|.|||||.||.||:||||||.|||.|..:..:||:....|:|..:|||.:||:.|: ||..::
Mosquito   324 MIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRELLKAEGIEVQ 388

  Fly   389 EEPPSS---EEEEDTADDELEAPLEIELESSTIQAV------------EKK---PKKKREKTDAE 435
            |.|...   |:.....|:.|       ::|..|::|            |||   |.:.|::|.:.
Mosquito   389 EGPDGKVVCEKRYANKDECL-------IKSDKIESVGGVVITEEGEDGEKKIHSPNRNRKRTGSS 446

  Fly   436 ----------KEELAKRKNEHQKEIEHAKTEQETLRNKLVSLEGKILVGGE-------------- 476
                      .|:|....||..:| :..:|||..::.:.|..|..:.|..:
Mosquito   447 TEMAVDQLQASEKLIAELNETWEE-KLKRTEQIRVQREAVFAEMGVAVKEDGITVGVFSPKKSPH 510

  Fly   477 --NLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKKIH 539
              ||.|.....|.||......|.:...||..:.|.:|...:.   |.:.:...::....:|...|
Mosquito   511 LVNLNEDPTLSECLLYYIKDGLTRLGTSEANVPQDIQLSGSH---ILKEHCVFENKDGVVTLVPH 572

  Fly   540 R---------------VMQ----MLMGVKSELADQQQEHQREKEGIYENIRSLSRELALCELVLN 585
            :               |:|    :::|..........|..|||       |..::|:.:||...|
Mosquito   573 KDALVYVNGRKVIEPEVLQTGSRVILGRNHVFRFTHPEQAREK-------REKNKEVDVCETPGN 630

  Fly   586 SYVPKEYQSMINQYTHWN 603
            |          .:...||
Mosquito   631 S----------GEIADWN 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	150/350 (43%)
		Smc	<433..>578	CDD:440809	34/189 (18%)
unc-104	XP_061509099.1	None