Protein Alignment Klp64D and Kif1b

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_038965095.1
• Gene: Kif1b / 117548
• RGDID: 621520
• Length: 1825
• Species: Rattus norvegicus
• Alignment Length: 823
• Identity: 238/823 - (28%)
• Similarity: 353/823 - (42%)
• Gaps: 224/823 - (27%)

  Fly    20 NVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATA-------NEPPKTYYFDNVFDGG 77
            :|:|.||.||.:..|.|          |.::.|..|:.|:|:       .|.||::.||..:...
  Rat     5 SVKVAVRVRPFNSRETS----------KESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSH 59

  Fly    78 SNQMD--------LYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAF 134
            ::..|        :|.|..:.::....||||..|.||||||.||:|||.|..:..|. ||||...
  Rat    60 TSPEDPCFASQSRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQA-GIIPQLC 123

  Fly   135 AHIFGHI-AKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHN 198
            ..:|..| ....|:..:.|.|||||||.|.|||||......:|.|:|.|.:|.:|:|||...|.:
  Rat   124 EELFEKINDNCNEDMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTS 188

  Fly   199 ADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSIT-VERSELGEGDVQHVRMGKLQLVDLAGSE 262
            ..|:.::|..|||.|.|.||.||:.||||||:|:|. .::.:..|.::...::.|:.||||||||
  Rat   189 YTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSE 253

  Fly   263 RQSKTQASGQRLKEATKINLSLSVLGNVISAL--VDG---------KSTHIPYRNSKLTRLLQDS 316
            |...|.|.|.||||...||.||:.||.|||||  ||.         |:..||||:|.||.||:::
  Rat   254 RADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLREN 318

  Fly   317 LGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQL 381
            |||||:|.|.|.:||||.||.||:||||||.|||.|:....|||:|...|:|..:||:.||:..|
  Rat   319 LGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLL 383

  Fly   382 EE---GDSLEEEP---------------------------------------------------- 391
            ..   ||.::.:|
  Rat   384 RAQGLGDIIDIDPLMDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSL 448

  Fly   392 -------------------PSSEE------EEDTADDELEAPLEIELESSTIQAVEKK------- 424
                               |..||      |.:....||....|.:|..:....:|::
  Rat   449 NSQAGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMG 513

  Fly   425 --------------PKK--------------------------KREKTDAEKEELAKRKNEHQKE 449
                          |||                          :..:.|||:.:.......|.||
  Rat   514 VAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKE 578

  Fly   450 IEHA--KTEQETLRNKLVSLE----GKILVGGENLLEKAQTQ---ELLL-----------EQSIA 494
             ||.  ::|:......:|:||    .:..|.|:.:....|.:   .:::           ||:.|
  Rat   579 -EHCIFRSERNNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFNHPEQARA 642

  Fly   495 ELEQHEKSE---EALKQTLQQK---ATERIDI-EERYSTLQDASTGITKKIHRVMQMLMGVKSEL 552
            |.|:...:|   |.:..|..|:   ..:.||: :|....||:            |::|...:.|.
  Rat   643 EREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQE------------MEILYKREKEE 695

  Fly   553 ADQQQEHQREKEGIYEN-IRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAY 616
            ||...|.||..   ||: :::|.:::....|...:...:|.:..: .:|....::.:|.
  Rat   696 ADLLLEQQRLD---YESKLQALQKQVETRSLAAETTEEEEEEEEV-PWTQHEFELAQWA------ 750

  Fly   617 TGNNMRKHISAHKTSGKEPDFLDLSHVYLSYNTDGVSNPMRSK 659
                .||..|...||.:  |.|..:.|||. ..:.:|..::.|
  Rat   751 ----FRKWKSHQFTSLR--DLLWGNAVYLK-EANAISVELKKK 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	155/359 (43%)
		Smc	<433..>578	CDD:440809	40/172 (23%)
Kif1b	XP_038965095.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	156/366 (43%)
		Kinesin_assoc	358..555	CDD:465047	26/196 (13%)
		FHA_KIF1B	530..639	CDD:438779	16/109 (15%)
		GimC	662..>719	CDD:440992	17/71 (24%)
		KIF1B	845..892	CDD:463574
		KIF1B	<956..975	CDD:463574
		DUF3694	1266..1422	CDD:463599
		PH_KIFIA_KIFIB	1710..1808	CDD:269939