DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp64D and KIF3A

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001287720.1	Gene:	KIF3A / 11127	HGNCID:	6319	Length:	726	Species:	Homo sapiens

Alignment Length:	708	Identity:	402/708 - (56%)
Similarity:	505/708 - (71%)	Gaps:	53/708 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQ 80
            :..:||:||||.||:::.|.|.....|:|||::...|||.|.: ::||||||:.||.||...|.|
Human    10 ESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTD-SSNEPPKTFTFDTVFGPESKQ 73

  Fly    81 MDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAK 145
            :|:|..|||||:|.|||||||||.||||||||||:||.|....|:.:|||||:|||||||||||:
Human    74 LDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHIAKAE 138

  Fly   146 ENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGN 210
            .:.:|||||||:||||||||||||||..:.||||||||:||::||||.|||:||||::.||.||:
Human   139 GDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGH 203

  Fly   211 KNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLK 275
            |||:||||.||:.||||||||:||:|.||.|.....|||||||.||||||||||:||.|:|||||
Human   204 KNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLK 268

  Fly   276 EATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETI 340
            ||||||||||.|||||||||||||||:|||||||||||||||||||||:|||.|.|||.||.|||
Human   269 EATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETI 333

  Fly   341 STLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEEPPSSEEEEDTADDE- 404
            ||||||:|||||:|:..|||:|||||||.||:||..|:|:||||:.:.....|..||:|..:.|
Human   334 STLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEV 398

  Fly   405 -------------------------LEAPLE-----------------IELESSTIQAVEKKPKK 427
                                     :|.||:                 ||:::.    ::::.|.
Human   399 GEDGEKRKKRRGSSSSSSSDSTCSVIEKPLDKFLPNQAGKKKVSPDKMIEMQAK----IDEERKA 459

  Fly   428 KREKTDAEKEELAKRKNE---HQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLL 489
            ...|.|.|:||..|.:.|   .:|::..|:.|.::|..||.:||.|::|||.:||.||:.||.||
Human   460 LETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLL 524

  Fly   490 EQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELAD 554
            |:|..|||:..|..|.|::.|::|..||:||||:|::||:.:.|.|||:.:|..|||..|||:||
Human   525 EESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMAD 589

  Fly   555 QQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTGN 619
            .|||||||.||:.||||.|||||.|..|::::::|::||.||..|.|||||||||||||||||||
Human   590 LQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDYQEMIENYVHWNEDIGEWQLKCVAYTGN 654

  Fly   620 NMRKHISAHKTSGKEPDFLDLSHVYLSYNTDGVSNPMRSKSARPRTS-GVPRPTTARR 676
            ||||.........|:|..:|||||||:|..:.:...: .|..||||| |..||.|.||
Human   655 NMRKQTPVPDKKEKDPFEVDLSHVYLAYTEESLRQSL-MKLERPRTSKGKARPKTGRR 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	238/332 (72%)
		Kinesin	26..352	CDD:278646	233/325 (72%)
		RILP-like	<437..556	CDD:304877	56/121 (46%)
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	238/332 (72%)
KIF3A	NP_001287720.1	SMC_prok_B	<450..>616	CDD:274008	79/169 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159601
Domainoid	1	1.000	459	1.000	Domainoid score	I490
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38266
Inparanoid	1	1.050	756	1.000	Inparanoid score	I563
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0001102
OrthoInspector	1	1.000	-	-		oto89872
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	1	1.000	-	-		X4842
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790