Protein Alignment Klp64D and Kif22

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_006507264.1
• Gene: Kif22 / 110033
• MGIID: 109233
• Length: 690
• Species: Mus musculus
• Alignment Length: 698
• Identity: 201/698 - (28%)
• Similarity: 315/698 - (45%)
• Gaps: 118/698 - (16%)

  Fly    18 IENVRVVVRTRPMDKNELSAGALSAI-SVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQM 81
            :..|||.||.||....|..|..|..: ::|..:..:.    |....:....|.||..:...|.|.
Mouse    36 LARVRVAVRLRPFMDGETEAKELPCVRAIDSCSLEVA----NWKKYQETLKYQFDAFYGEKSTQQ 96

  Fly    82 DLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKE 146
            ::||.:.:||:..:|||.|.::||||.||.|||:||.|:|:.|   |:||.|...:. .:|:.:.
Mouse    97 EVYVGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQP---GVIPRALMDLL-QLAREES 157

  Fly   147 NQ----KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMR 207
            .:    ...|.:||:|||.|:|.|||....| .|.::|.....:.:..|:...:.:..|.|....
Mouse   158 AEGRPWDVSVAMSYLEIYQEKVLDLLDPASG-DLVIREDCRGNILIPGLTQKPITSFSDFEQHFL 221

  Fly   208 LGNKNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQ 272
            ..::|||||||::||.||||||:..:.|::.|......|  |.|||.|:||||||...:|...|.
Mouse   222 PASRNRAVGATRLNQRSSRSHAVLLVKVDQRERLTPFRQ--REGKLYLIDLAGSEDNRRTGNQGI 284

  Fly   273 RLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYM 337
            ||||:..||.||.|||.|:.||..| ...||||:|||||||||||||::.:::.|.|:|....|.
Mouse   285 RLKESGAINTSLFVLGKVVDALNQG-LPRIPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYQ 348

  Fly   338 ETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEEPPSSEEEEDTAD 402
            :|||.|.:.:|:|.:.||...||    :|..|....:...:|:| .|.|..::....|||...:.
Mouse   349 DTISALNFTARSKEVINRPFTNE----SLQPHALAPVKLSQKEL-LGPSEAKKAKGPEEESTGSP 408

  Fly   403 DELEAPLEIELESSTIQAVE----------------------------KKPKKKREKTDAEKEEL 439
            :...||.....:.|.:|.:.                            ..||:       |:..|
Mouse   409 ESTAAPASASQKLSLLQKLSNMDPAMLENLLSMERLLGSQGSQGTPLLNTPKR-------ERMVL 466

  Fly   440 AKRKNEHQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEE 504
            .|...|...|||..|.:|:.|..|:::.|      ..:..||..|..:|...:.......:..::
Mouse   467 MKTVEEKNLEIERLKMKQKELEAKVLAQE------APDPREKENTPTILQPPASYSGTVAKPLKK 525

  Fly   505 ALKQTLQQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYEN 569
            |:...||:...:|                  :..:::..:..|.|.:|....:....||:..|..
Mouse   526 AVVMPLQRIQKQR------------------ESSNQIQLLKKGPKRKLEPSPESEAVEKDEDYWE 572

  Fly   570 IRSLSREL------ALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNNMRKHISAH 628
            :: :|.||      .|.:| ||....:|.:|:        :.||:.:.:.:          :...
Mouse   573 VQ-ISPELLAHGRKKLLDL-LNEGSARELRSL--------QRIGQKKAQLI----------VGWR 617

  Fly   629 KTSGKEPDFLDLSHVYLSYNTDGVSNP-----MRSKSARPRTSGVPRP 671
            :..|...:..||..|      :|:|..     ::.:...|...|||.|
Mouse   618 ELHGPFSEVEDLEQV------EGISGKQVESFLKVRPPLPFLHGVPPP 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	134/337 (40%)
		Smc	<433..>578	CDD:440809	29/150 (19%)
Kif22	XP_006507264.1	KISc_KID_like	38..361	CDD:276827	133/334 (40%)
		ComEA	591..641	CDD:441164	12/73 (16%)