DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp64D and KIF1C

DIOPT Version :10

Sequence 1:NP_523934.1 Gene:Klp64D / 38611 FlyBaseID:FBgn0004380 Length:677 Species:Drosophila melanogaster
Sequence 2:NP_006603.2 Gene:KIF1C / 10749 HGNCID:6317 Length:1103 Species:Homo sapiens


Alignment Length:727 Identity:230/727 - (31%)
Similarity:326/727 - (44%) Gaps:169/727 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 NVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVF--------DG 76
            :|:|.||.||.:..|.|..|...:|:.  ....:::.|. .:.:.||::.||..:        ..
Human     5 SVKVAVRVRPFNARETSQDAKCVVSMQ--GNTTSIINPK-QSKDAPKSFTFDYSYWSHTSTEDPQ 66

  Fly    77 GSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHI 141
            .::|..:|.|....::....||||..|.||||||.||:|||.|..: |..:||:|.....:|..:
Human    67 FASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQE-PGQQGIVPQLCEDLFSRV 130

  Fly   142 AKAKENQ----KFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDL 202
            :   |||    .:.|.|||||||.|.|||||......||.|:|.|.:|.:|:|||...|.:..|:
Human   131 S---ENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQDLSKLAVTSYADI 192

  Fly   203 ENIMRLGNKNRAVGATKMNQESSRSHAIFSIT-VERSELGEGDVQHVRMGKLQLVDLAGSERQSK 266
            .::|..|||.|.|.||.||:.||||||:|:|. .:|.......:...::.|:.|||||||||...
Human   193 ADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERADS 257

  Fly   267 TQASGQRLKEATKINLSLSVLGNVISALVD-----GKSTHIPYRNSKLTRLLQDSLGGNSKTVMC 326
            :.|.|.||||...||.||:.||.|||||.|     .||..||||:|.||.||:::|||||:|.|.
Human   258 SGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMI 322

  Fly   327 ATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQL---------- 381
            |.:||||.||.||:||||||.|.|.|:....|||:|...|:|..|||:||||:.|          
Human   323 AALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLSASAL 387

  Fly   382 -----EEGD------SLEEEP-PSSEEEEDTADDELEAPLEIELES--------STIQAVEK--- 423
                 |||.      ::...| |.|.....|.:.|||.......||        ..:|..||   
Human   388 EGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETEKIIA 452

  Fly   424 ----KPKKKREKTDA---EKEEL------------------AKRKNEHQKEIE-----------H 452
                ..::|..||:|   |:|.|                  :.:|..|...:.           |
Human   453 ELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYH 517

  Fly   453 AK--------------------TEQETLRNKLVSLEGKILV------GGENLLE-KAQTQELLL- 489
            .|                    .||..|...:...:|:::|      |.|..:. |..|:.|:| 
Human   518 IKDGVTRVGQVDMDIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVLK 582

  Fly   490 ------------------EQSIAELEQ------HEKSEE-----ALKQTLQQKATE-RIDIEERY 524
                              ||:..|.|:      ...||.     |.|:.|:|:..: ::::|:| 
Human   583 SGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKR- 646

  Fly   525 STLQDASTGITKKIHRVMQMLMGVKSE---LADQQQEHQREKEGIYENIRSLSRELALCELVLNS 586
              |||......|:           |.|   |.:||:.:.....|...:.||......|...:...
Human   647 --LQDLENQYRKE-----------KEEADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQ 698

  Fly   587 YVPKEYQSMINQ 598
            ..|...|:::.:
Human   699 LPPTTVQTIVKR 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp64DNP_523934.1 KISc_KIF3 19..352 CDD:276822 151/349 (43%)
Smc <433..>578 CDD:440809 43/237 (18%)
KIF1CNP_006603.2 KISc_KIF1A_KIF1B 4..355 CDD:276816 152/356 (43%)
Kinesin_assoc 352..522 CDD:465047 40/169 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 400..438 9/37 (24%)
FHA_KIF1C 498..599 CDD:438780 14/100 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 808..828
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 874..924
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 950..1103
Blue background indicates that the domain is not in the aligned region.

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