Protein Alignment Klp64D and CENPE

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001804.2
• Gene: CENPE / 1062
• HGNCID: 1856
• Length: 2701
• Species: Homo sapiens
• Alignment Length: 802
• Identity: 237/802 - (29%)
• Similarity: 366/802 - (45%)
• Gaps: 202/802 - (25%)

  Fly    21 VRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQMDLYV 85
            |.|.||.||::..|.|.|..:.:.....|..|..:       :..|::.||.||.|.....::|.
Human     7 VAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQV-------DGSKSFNFDRVFHGNETTKNVYE 64

  Fly    86 DTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAKENQKF 150
            :.|.||:|..::||||||.|||||.:||||||.|:.|.   .|:||.|...||..|.|..: ::|
Human    65 EIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDH---LGVIPRAIHDIFQKIKKFPD-REF 125

  Fly   151 LVRVSYMEIYNEEVRDLL-GKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGNKNRA 214
            |:||||||||||.:.||| |....|.|.::|..:..|:|.||:..||:.::.....:..|.|:|.
Human   126 LLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWITKGEKSRH 190

  Fly   215 VGATKMNQESSRSHAIFSITVERSELG-----EGDVQHVRMGKLQLVDLAGSERQSKTQASGQRL 274
            .|.|||||.|||||.||.:.:|..|.|     ||.   |::..|.|||||||||.::|.|:|.||
Human   191 YGETKMNQRSSRSHTIFRMILESREKGEPSNCEGS---VKVSHLNLVDLAGSERAAQTGAAGVRL 252

  Fly   275 KEATKINLSLSVLGNVISALVDGK-STHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYME 338
            ||...||.||.:||.||..|.||: ...|.||:|||||:||:|||||:||.:..||:|.  ::.|
Human   253 KEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPV--SFDE 315

  Fly   339 TISTLRYASRAKNIQNRMHINEEPKD-ALLRHFQEEIARLRKQLEEGDSLEEEPPSSE------- 395
            |::.|::||.||.::|..::||...| |||:.:::||..|:||||| .|||....:.|
Human   316 TLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEE-VSLETRAQAMEKDQLAQL 379

  Fly   396 -EEED-----------------------TADDELEA---------------------------PL 409
             ||:|                       |...||:|                           |.
Human   380 LEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPT 444

  Fly   410 EI-------------ELESS-------------TIQAVEKKPKKK-------------------- 428
            .|             |::.|             |:..:|..|..|
Human   445 NITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDN 509

  Fly   429 -------------------REKTDAEKEELAKRKNEHQKE-------------IEHAKTEQETLR 461
                               :||.|.::.|..:||.:..:|             ::||:...:.|.
Human   510 LVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLE 574

  Fly   462 NKLVSLEGKILVGGENLLEKAQ----TQELL-----LEQSIAELEQHEKSEEALKQTLQQKATER 517
            |:| |.:.::|...|:.::|.|    :|:|.     |..|:..:|..::    :||||....|..
Human   575 NEL-SSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ----MKQTLFDAETVA 634

  Fly   518 IDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKE---GIYENIRSLSRELAL 579
            :|.:...:.|:..:..:.:|:..:......:::::...|.:.:.:|:   .:.:.::|...|:..
Human   635 LDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITK 699

  Fly   580 CELVLNSYVPK-------------EYQSMINQYTHWNEDIGE-----WQLKCVAYTGNNMRKHIS 626
            ...:::..|||             :.|..:|:....||.:.|     .:||.:......:||.|.
Human   700 LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQ 764

  Fly   627 AHK------TSGKEPDFLDLSH 642
            ...      ||.|:..|.::.|
Human   765 DKSEELHIITSEKDKLFSEVVH 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	151/337 (45%)
		Smc	<433..>578	CDD:440809	32/169 (19%)
CENPE	NP_001804.2	KISc_CENP_E	6..329	CDD:276825	151/337 (45%)
		SMC_prok_B	345..1131	CDD:274008	80/448 (18%)
		SMC_prok_B	828..1715	CDD:274008
		SMC_prok_B	1332..2129	CDD:274008
		SMC_N	1730..>2573	CDD:481474
		Kinetochore-binding domain	2126..2476
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2355..2376
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2508..2533
		Globular autoinhibitory domain. /evidence=ECO:0000250	2510..2698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2588..2701