DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp64D and kif26a

DIOPT Version :9

Sequence 1:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_004917245.2	Gene:	kif26a / 100491850	XenbaseID:	XB-GENE-6051360	Length:	2010	Species:	Xenopus tropicalis

Alignment Length:	782	Identity:	191/782 - (24%)
Similarity:	314/782 - (40%)	Gaps:	240/782 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANE----------PPKTYYFDN 72
            |..|:::||..|....:.::.::|.:.||...:.:|:..|:.....          .||.:.||:
Frog   405 IGKVKIMVRICPFQGPQNTSESMSFLKVDPRKKQVTLYDPSTCGPSVSVHRRAVVAVPKMFAFDS 469

  Fly    73 VFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHI 137
            ||...::|.::...|...::..|:.|.:|.|..:|....||:|||.|...|.|:.||||.|.:.:
Frog   470 VFPQDASQAEVCSGTVAEVIQSVVNGADGCIFCFGHVRLGKSYTMIGKDASTQSLGIIPCAISWL 534

  Fly   138 FGHIAKAKE--NQKFLVRVSYMEIY--NEEVRDLLGKDVGKSLEVKERPDIGVFVKD--LSGYVV 196
            |..|.:.||  ..:|.:|||.:||:  :|.::|||.::...||:..:.|  ||::::  :.|..:
Frog   535 FKLINERKEKTGTRFSIRVSAVEIFGKDENLKDLLAEEATGSLQDGQSP--GVYLREDPICGTQL 597

  Fly   197 HNADDLE--------NIMRLGNKNRAVGATKMNQESSR-SHAIFSITV-----ERSELGEGDVQH 247
            .|..:|.        :.:......|:......::|..| ||.:|::.:     |:|  |:|.:..
Frog   598 QNQSELRAPTAEKAAHFLDAALAARSTSRPDCDEEERRNSHMLFTLHIYQYRMEKS--GKGGMSG 660

  Fly   248 VRMGKLQLVDLAGSER---QSKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKL 309
            .| .:|.|:||...|:   :|:....|        :.|||:.|||||.|||:| :.|||||:|||
Frog   661 GR-SRLHLIDLGSCEKVLSKSRDGCGG--------LCLSLTALGNVILALVNG-AKHIPYRDSKL 715

  Fly   310 TRLLQDSLGG-NSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEE 373
            |.|||:|||. |.:|.|.|.||.:.:||.||:||::.|||
Frog   716 TMLLQESLGNINCRTTMIAHISDSPANYQETLSTVQLASR------------------------- 755

  Fly   374 IARLRKQLEE-------GDSLEEE-----PP-----------------------------SSEEE 397
            |.|::|:..:       |:|..||     ||                             |||:.
Frog   756 IHRMKKKKSKYASSSSGGESSCEEGRVRRPPHIRPFHQRTVVLDPDFPTLGFHSDPDYSSSSEQS 820

  Fly   398 EDT-----------ADDEL---EAPLE-IELESSTIQAVEKKPKKKREKTDAEKEELAKRKNEHQ 447
            .||           :|.||   |.|.| :.:..|.:        |||.|.:.  ..:....|:|.
Frog   821 CDTVIYVGPNGAALSDKELTDNEGPPEFVPIIPSLL--------KKRSKDNL--SSIRSSDNDHL 875

  Fly   448 KEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLEQSIA---------ELEQHEKSE 503
            |    ..|..| |:.:|..::|           ..:....|:|:.:|         |...|...|
Frog   876 K----CNTFAE-LQERLECIDG-----------SEEPARFLIEEPVAAHCNKAMNYEDNVHSTKE 924

  Fly   504 EAL----------KQTLQQKATERIDIEERY-STLQDASTGITKKIHRVMQMLMGVKSELADQQQ 557
            :.|          :..:..|..:.|.|...: ..:.|:.|...:..|              :..|
Frog   925 KTLLSGICKRPGFQDMVSPKKGQNIIISTAFPPNISDSETNAPQSAH--------------EHPQ 975

  Fly   558 EHQREK--------EGIYENIRSLSRELA--LCE-----------------LVLNSYVPKEYQSM 595
            :|.:.:        :|....|..|.:.||  :|:                 |:...::|......
Frog   976 QHAKAENVKPECISDGNQVTIMDLQKTLAPSVCKAQEIPKGATEISVKEKALMARRHLPSPAPPP 1040

  Fly   596 INQYTHWNE------DIGEWQLKC------VAYT------------GNNMRKHISAHKTSGKEPD 636
            .:|....|.      .||..:|||      |:.|            ...:|:..||.||:|.:.|
Frog  1041 GSQSCSSNNVGVRTPPIGMSKLKCQDKHKLVSSTLPVGISTPKQPGPIEVRRFRSAVKTNGFDRD 1105

  Fly   637 FL 638
            .|
Frog  1106 IL 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	117/366 (32%)
		Kinesin	26..352	CDD:278646	115/359 (32%)
		RILP-like	<437..556	CDD:304877	21/138 (15%)
kif26a	XP_004917245.2	KISc	407..757	CDD:276812	117/388 (30%)
kif26a	XP_004917245.2	DUF5401	<1868..>1975	CDD:375164
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000