Protein Alignment Klp64D and cenpe

DIOPT Version :10

• Sequence 1: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_004911147.2
• Gene: cenpe / 100126678
• XenbaseID: XB-GENE-952286
• Length: 3358
• Species: Xenopus tropicalis
• Alignment Length: 673
• Identity: 226/673 - (33%)
• Similarity: 326/673 - (48%)
• Gaps: 148/673 - (21%)

  Fly    17 EIENVRVVVRTRPM------DKNEL--SAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNV 73
            |.:.|:|.||.||:      |::.|  .||:.:...||                 ..|::.||.|
 Frog     3 EEDAVKVCVRVRPLIQREQGDQSTLLWKAGSNTISQVD-----------------GTKSFSFDRV 50

  Fly    74 FDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIF 138
            |:...:...:|.:.|.||:...|:||||||.|||||.:||||||.|.|:|   .||||.|...:|
 Frog    51 FNSHESTSQVYQEIAVPIIQSALQGYNGTIFAYGQTSSGKTYTMMGTPNS---LGIIPQAIQEVF 112

  Fly   139 GHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKD-VGKSLEVKERPDIGVFVKDLSGYVVHNADDL 202
             .|.:...|::||:||||||||||.|:|||..| ..|.||::|..:..|:|.||:..:|...|.:
 Frog   113 -KIIQEIPNREFLLRVSYMEIYNETVKDLLCDDRKKKPLEIREDINRNVYVADLTEELVMVPDHV 176

  Fly   203 ENIMRLGNKNRAVGATKMNQESSRSHAIFSITVE--------RSELGEGDVQHVRMGKLQLVDLA 259
            ...::.|.|||..|.||||..|||||.||.:.||        .||..:|.|.   :..|.|||||
 Frog   177 IQWIKKGEKNRHYGETKMNDHSSRSHTIFRMIVESRDRNDSANSENCDGAVM---VSHLNLVDLA 238

  Fly   260 GSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGKS-THIPYRNSKLTRLLQDSLGGNSKT 323
            ||||.|:|.|.|.||||...||.||.:||.||..|.||:: ..|.||:|||||:||:|||||:||
 Frog   239 GSERASQTGAEGVRLKEGCNINRSLFILGQVIKKLSDGQAGGFINYRDSKLTRILQNSLGGNAKT 303

  Fly   324 VMCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKD-ALLRHFQEEIARLRKQLEEGDSL 387
            |:..||:|.  ::.||:|||::||.||:::|..|:||...| |||:.:::||..|:||||:   |
 Frog   304 VIICTITPV--SFDETLSTLQFASTAKHMRNTPHVNEVLDDEALLKRYRKEILELKKQLED---L 363

  Fly   388 EEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKPKKKRE-------------KTDAEKEEL 439
            |            ...|::|....:.|.|.:.|..|..:|:||             ..::::::.
 Frog   364 E------------TSSEIKAQAMAKEEHSQLLAEIKLLQKEREDRIWHLTNIVVASSQESQQDQR 416

  Fly   440 AKRKNEHQKEIEHAKTE-QETLRNKLVS-------LEGKILVGGENLLEKAQTQELLLEQSIAEL 496
            .|||    :.:..|..: ..:|....||       |.|       |..:||:..:|
 Frog   417 VKRK----RRVTWAPGKIHSSLHGSSVSDFDMPSRLPG-------NFSKKAKFSDL--------- 461

  Fly   497 EQHEKSEEALKQTLQQKATERIDIEERYSTLQ----DASTGITKKIHR-----VMQMLMGVKSEL 552
                   .|..:......||..|.::..|.:.    ||......|:.|     :.|.:|..:..:
 Frog   462 -------PAFPEIDDSVCTEFSDFDDPISMIDNNGIDAEWNFASKVTRREKASLHQSMMDFEGRI 519

  Fly   553 ADQQQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNED----IGEWQLKC 613
            :|..|.|..            |:|:|.|.   .:...||..|:..|.....|:    :..::||.
 Frog   520 SDSVQFHDS------------SKEMAECR---RASFEKEITSLQQQLQSKEEEKRQLVQSFELKI 569

  Fly   614 VAYTG------------NNMRKH 624
            ....|            .::|:|
 Frog   570 TELEGQLRDRAKNLEMVTDLREH 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	158/350 (45%)
		Smc	<433..>578	CDD:440809	29/161 (18%)
cenpe	XP_004911147.2	KISc_CENP_E	6..330	CDD:276825	158/349 (45%)
		SMC_prok_B	551..1422	CDD:274008	6/42 (14%)
		SMC_prok_B	1178..2115	CDD:274008
		SMC_prok_B	1759..2611	CDD:274008
		SMC_prok_B	2220..3059	CDD:274008