DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lama and plbd2

DIOPT Version :9

Sequence 1:	NP_001261440.1	Gene:	lama / 38610	FlyBaseID:	FBgn0016031	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_001076460.1	Gene:	plbd2 / 100009622	ZFINID:	ZDB-GENE-070209-116	Length:	550	Species:	Danio rerio

Alignment Length:	607	Identity:	164/607 - (27%)
Similarity:	251/607 - (41%)	Gaps:	135/607 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 YKDSVYENGWAQIEVETQRTYPDWVQAYAAGMLEGSLTWRNIYNQWSNTISSSCERDESTQKFCG 143
            :.|.:...|||.:::.|...|.|.:||||||::||:.|.:.:|..|.||:...|....|...||.
Zfish    50 FTDHINTTGWAYLDLSTSAGYNDSLQAYAAGLVEGAATSQLLYKHWMNTLMGYCGPFSSDVGFCE 114

  Fly   144 WLRDLLTTNYHRLKRQTEKAENDHYWHQLHLFITQLEGLETGYKRGASRARSDLEEEI----PFS 204
            .|:|.::||...:.:|.|...:..||||:.|.:.||:|||.||     ..|.|.....    ||.
Zfish   115 RLKDYISTNLQWMWQQMETHTHSPYWHQVRLSLLQLKGLEDGY-----NGRIDFPSGSFSINPFG 174

  Fly   205 DFLLMNAAADIQDLKIYYENYELQNSTEHTEEPGTDQPKNFFLPSATMLTKIVQEEESPQVLQLL 269
             |||.....|::||:      ...|.:..:...|:.        |.:.|.|::     |....||
Zfish   175 -FLLFQMGGDLEDLE------AALNKSSQSRSVGSG--------SCSALIKLL-----PGHKDLL 219

  Fly   270 FGHSTAGSYSSMLRIQKRYKFHYHFSSKLRSNTVPGVDITFTGYPGILGSTDDFYTIKGR--HLH 332
            ..|.|..:|.|||||.|||...|. :|....:.:||....|:.|||.:.|.||||.|...  .|.
Zfish   220 VSHDTWNNYQSMLRIMKRYSLSYR-TSPTEQDVIPGATQVFSSYPGSIFSGDDFYLISSGLVTLE 283

  Fly   333 AIVGGVGIKNENLQLWKTVDPKKMVPLVARVMAANRISQNRQTWASAMSRH-PFTGAKQWITVDL 396
            ..:|     |.|..|||.|.|:..|....|.:.|||::.:.|:||...||: ..|...||:.||.
Zfish   284 TTIG-----NSNAALWKFVQPRGSVMEWLRNIVANRLAGDGQSWAQTFSRYNSGTYNNQWMVVDY 343

  Fly   397 NKMKVQDNLYNVLEGDDKHDDAPVVLNEKDRTAIQQRHDQLRDMVWIAEQLPGMMTKKDVTQGFL 461
            .         |.:.|.                |:.:     :.:..:.||:|||:...|.|....
Zfish   344 K---------NFVPGQ----------------AVAK-----QGLFTVLEQIPGMIKTADKTTELF 378

  Fly   462 VPGNTSWLANGVPYFKNVLELSG-----------VNYSED--QQLTVADEEELTSLASVDKYLRT 513
            ..|  .|.:..:|||:.|...||           .::|::  .|:...::.::|.:.|:::.:|.
Zfish   379 QTG--YWASYNIPYFEEVFNASGGQELVQKYGSWFSFSQNPRAQIFRRNQTQVTDIQSMERLMRY 441

  Fly   514 HGFRGDLLG-SQESIAYGNIDLKLFSYNARLGISDFHAFAGPVFLRFQHTQPRTLEDEGQDGGVP 577
            :.:..|.|. .:|...:.|.:   .|.:||   ||.:...|        :.|.....:...||.
Zfish   442 NNYLEDPLSRCEECDPHQNAE---NSISAR---SDLNPANG--------SYPFGALQQRPHGGT- 491

  Fly   578 PAASMGDERLSVSIEDADSLAEMELITERRSVRNDMRAIAMRKIGSGP-------FKWSEMSPVE 635
                      .:.:..:....:.||:.                 .|||       |:||. ||.
Zfish   492 ----------DMKMTSSSMFRQWELLA-----------------ASGPSCEQTPVFQWSR-SPY- 527

  Fly   636 EGGGHEGHPDEWNFDKVSPKWA 657
            ....|.|.||.|:|..|..:||
Zfish   528 SSLMHMGQPDRWDFPTVHVRWA 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lama	NP_001261440.1	Phospholip_B	19..654	CDD:282734	162/602 (27%)
plbd2	NP_001076460.1	Phospholip_B	45..544	CDD:282734	161/600 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I3618
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	174	1.000	Inparanoid score	I4062
OMA	1	1.010	-	-		QHG54246
OrthoDB	1	1.010	-	-		D167631at33208
OrthoFinder	1	1.000	-	-		FOG0002308
OrthoInspector	1	1.000	-	-		otm25492
orthoMCL	1	0.900	-	-		OOG6_101392
Panther	1	1.100	-	-	LDO	PTHR12370
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4061
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980