Protein Alignment KRT14 and krt97

DIOPT Version :10

• Sequence 1: NP_000517.3
• Gene: KRT14 / 3861
• HGNCID: 6416
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_001002383.1
• Gene: krt97 / 436656
• ZFINID: ZDB-GENE-040718-78
• Length: 438
• Species: Danio rerio
• Alignment Length: 467
• Identity: 239/467 - (51%)
• Similarity: 313/467 - (67%)
• Gaps: 48/467 - (10%)

Human     5 SRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTY---GGGLSVSSSRFSSGGACGLG 66
            ||:..|||....|..:.||.   |.||    |.|  ||||.|   ||.:.||.::.|.
Zfish     9 SRKSVSSSRPFSSQSLTGGY---SKRI----AVG--RAPSVYAGAGGSVRVSYAQSSR------- 57

Human    67 GGYGGGFSSSSSSFGSGFGGGYGGGLGAGLGGGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLD 131
                |||..||:.              ||...|||         :|.:||.|||||||||||||:
Zfish    58 ----GGFDMSSAL--------------AGGDNGFG---------MVVNEKTTMQNLNDRLASYLE 95

Human   132 KVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTIEDLRNKILTATVDNANVLLQIDNARLA 196
            |||:||:|||:||.:||:||.::.|.. :|||.|:.||||||.||..|:.|||.::||||||:||
Zfish    96 KVRSLEKANAELERQIREWYDKRTPVS-RDYSHYYVTIEDLRKKISVASQDNARIILQIDNAKLA 159

Human   197 ADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALR 261
            |:|||.|||.||.||:||||||.|||:|||:||:.|:|||||||.|||||.||||||.||:.|||
Zfish   160 AEDFRVKYENELALRLSVEADIAGLRKVLDDLTMTRSDLEMQIEGLKEELVYLKKNHAEELAALR 224

Human   262 GQV-GGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQ 325
            .|: ...||||:||||..||:||:.|||.|||.:.|||:::.|.|:..|.:|||::|:|..|.:.
Zfish   225 AQMTSSSVNVEVDAAPQQDLARIMEEMRQQYEGITEKNKREMEAWYKGKFDELNKQVSTRQEDLS 289

Human   326 SGKSEISELRRTMQNLEIELQSQLSMKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCE 390
            ..::||:|||||:|.||||||||||:|::||.:|.||:.||.:||.|:|.:|.|:|::|.|:|.:
Zfish   290 MSRNEINELRRTLQALEIELQSQLSLKSALEGTLGETESRYSIQLNQLQAVINSLEQELTQMRMD 354

Human   391 MEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSGSQSSRDVTSSSRQIRTKVMDV 455
            :|:|..|||:|||:|||||.|||.|||||:|||....:.:........:.....::::||.:.:|
Zfish   355 IERQASEYKLLLDIKTRLEMEIAEYRRLLDGEDIQRQTIKVVEVVAPPKPDPVVTKRVRTVIEEV 419

Human   456 HDGKVVSTHEQV 467
            .||||||..|.|
Zfish   420 VDGKVVSRTEDV 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT14	NP_000517.3	Head	1..114		34/111 (31%)
		Filament	114..425	CDD:459643	194/311 (62%)
		Coil 1A	115..150		27/34 (79%)
		Linker 1	151..168		6/16 (38%)
		Coil 1B	169..260		65/90 (72%)
		Linker 12	261..283		12/22 (55%)
		Coil 2	284..422		75/137 (55%)
		Tail	423..472		12/45 (27%)
		Interaction with Type I keratins and keratin filaments	425..472		11/43 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..472		11/42 (26%)
krt97	NP_001002383.1	Filament	78..387	CDD:459643	192/309 (62%)