DRSC/TRiP Functional Genomics Resources

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Protein Alignment KRT14 and CG14355

DIOPT Version :10

Sequence 1:NP_000517.3 Gene:KRT14 / 3861 HGNCID:6416 Length:472 Species:Homo sapiens
Sequence 2:NP_650340.1 Gene:CG14355 / 41723 FlyBaseID:FBgn0038208 Length:1024 Species:Drosophila melanogaster


Alignment Length:176 Identity:52/176 - (29%)
Similarity:67/176 - (38%) Gaps:42/176 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    19 GIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSSRFSSGGACGLGGGYGGGFSSSSSSFGSG 83
            |:.|.:|||... .:.:..|..|.|..:|.|..      ..||..|.|||..|......|:.|.|
  Fly   808 GVFGMMGGGPHG-PNPMPCGRPRVPGAWGVGAG------GDGGGIGGGGGARGVLGGGRSARGGG 865

Human    84 FGGGYG----GGLGAGLGGGFGGGF-------AGGDGLLVG--SEKVTMQNLNDRLASYLDKVRA 135
            .||| |    ||.|.|.|||...||       |.|.|...|  ||.:.::.....|....:..:|
  Fly   866 AGGG-GFRGPGGPGGGPGGGAWKGFPTAAVGKAQGQGKGKGEKSEPIPVRYPKRFLKPAEEAAKA 929

Human   136 LEEA-NADLEVK----------------IRDWYQRQRPAEIKDYSP 164
            .:|| .|.::.|                :|.|    .|.|.||..|
  Fly   930 AKEAEKAAVDAKKKGINMIKYLQKKGTLVRPW----NPQEGKDKRP 971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT14NP_000517.3 Head 1..114 37/107 (35%)
Filament 114..425 CDD:459643 15/68 (22%)
Coil 1A 115..150 8/51 (16%)
Linker 1 151..168 5/14 (36%)
Coil 1B 169..260
Linker 12 261..283
Coil 2 284..422
Tail 423..472
Interaction with Type I keratins and keratin filaments 425..472
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 426..472
CG14355NP_650340.1 DUF4788 41..265 CDD:406440
DUF4776 345..788 CDD:406413
Blue background indicates that the domain is not in the aligned region.

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