Protein Alignment KRT14 and LamC

DIOPT Version :10

• Sequence 1: NP_000517.3
• Gene: KRT14 / 3861
• HGNCID: 6416
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_001260974.1
• Gene: LamC / 36615
• FlyBaseID: FBgn0010397
• Length: 640
• Species: Drosophila melanogaster
• Alignment Length: 415
• Identity: 127/415 - (30%)
• Similarity: 195/415 - (46%)
• Gaps: 96/415 - (23%)

Human   115 EKVTMQNLNDRLASYLDKVRALEEANADLEVKI---RDWYQRQRPAEIKDYSPYFKTIEDLRNKI 176
            ||..:|:||||||.|:|::|.||..|:.|..::   :|...|: .:.:|  :.|.|.:...| |:
  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRE-TSNLK--AVYEKELAAAR-KL 106

Human   177 LTATVDNANVLLQIDNARLAAD--------DFRTKYET--ELNLRMSVEA--DING--------- 220
            |..|. .....|:||..||..:        |.:||..|  |.|.|:....  ::||
  Fly   107 LDETA-KEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADR 170

Human   221 ----------------LRRVLDEL-------TLARADLEMQIESLKEELAYLKKNHEEEMNALR- 261
                            |||.||:|       ||||.|||.|.:||:||||:..:.|.:|:...|
  Fly   171 KKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRS 235

Human   262 ------GQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEEL----NRE 316
                  .::.|.::.:.:|    .|.:.|.|:|||||.....||::.|..:..:.:.|    ||.
  Fly   236 RRQIEISEIDGRLSRQYEA----KLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRA 296

Human   317 V---ATNSELVQSGKSEISELRRTMQNLEIELQSQLSMK-ASLENSLEETKGRYCMQLAQIQEMI 377
            .   |..:|.|:..:::|..|...:|||| :..:.|:.: ..|||.|:..:.|:       .:.|
  Fly   297 AQGSALATEEVRLMRTKIDGLNAKLQNLE-DTNAGLNARIRELENLLDTERQRH-------NQYI 353

Human   378 GSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHL---------------S 427
            .|:|.:|.::|.||..|.|||:.|:|:|..|:.|||.|.:||.||:..|               |
  Fly   354 ASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISS 418

Human   428 SSQFSSGSQSSRD--VTSSSRQIRT 450
            :....:.|.|||.  ||.|.|:..|
  Fly   419 NGSHLTASASSRSGRVTPSGRRSAT 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT14	NP_000517.3	Head	1..114
		Filament	114..425	CDD:459643	116/371 (31%)
		Coil 1A	115..150		16/37 (43%)
		Linker 1	151..168		3/16 (19%)
		Coil 1B	169..260		40/134 (30%)
		Linker 12	261..283		4/28 (14%)
		Coil 2	284..422		49/145 (34%)
		Tail	423..472		11/45 (24%)
		Interaction with Type I keratins and keratin filaments	425..472		11/43 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..472		11/42 (26%)
LamC	NP_001260974.1	Filament	45..401	CDD:459643	116/371 (31%)
		PRK13922	154..>221	CDD:473155	21/66 (32%)
		LTD	474..574	CDD:460003