DRSC/TRiP Functional Genomics Resources

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Protein Alignment KRT14 and Lam

DIOPT Version :10

Sequence 1:NP_000517.3 Gene:KRT14 / 3861 HGNCID:6416 Length:472 Species:Homo sapiens
Sequence 2:NP_476616.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster


Alignment Length:408 Identity:124/408 - (30%)
Similarity:193/408 - (47%) Gaps:91/408 - (22%)


- Green bases have known domain annotations that are detailed below.


Human   114 SEKVTMQNLNDRLASYLDKVRALEEANADLEVKI---RDWYQRQRP------------------- 156
            :|||.:||||||||:|:|:||.||..|:.|.:::   ||...|:..                   
  Fly    53 AEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDD 117

Human   157 -------AEIKDYSPYFKTIEDLRNKI----LTATVDNANVLL------QIDNARLAADDFRTKY 204
                   ||| |....::..|:|:||:    ...|....||.:      :::|....|:..|.|.
  Fly   118 TARDRARAEI-DIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKL 181

Human   205 ETELN--------LRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALR 261
            ..:||        ||...|.    .|:.|::.||:|.|||..|:||:|||::..:.|.:|:|..|
  Fly   182 NEDLNEALKELERLRKQFEE----TRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESR 242

Human   262 -------GQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVAT 319
                   .::.|.::.|.||    .|.:.|.|:|.|||:..:.||.:.:..:..|.:.|....|.
  Fly   243 RIKQTEYSEIDGRLSSEYDA----KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAAR 303

Human   320 NSELVQSGKSEISELRRTMQNL--------EIELQSQLSMKA---SLENSLEETKGRYCMQLAQI 373
            .|   .|....|.|||.|...:        |:| |:...:.|   .||..|:..:.|:..:    
  Fly   304 TS---NSTHKSIEELRSTRVRIDALNANINELE-QANADLNARIRDLERQLDNDRERHGQE---- 360

Human   374 QEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHL------SSSQFS 432
               |..:|::|.:||.||.||.:||:.|:|:|..|:.|||.|.:||.||:|.|      :::...
  Fly   361 ---IDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQ 422

Human   433 SGSQSSRDVTSSSRQIRT 450
            |.|||.|:.|.::...||
  Fly   423 SFSQSLRNSTRATPSRRT 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT14NP_000517.3 Head 1..114 124/408 (30%)
Filament 114..425 CDD:459643 114/375 (30%)
Coil 1A 115..150 20/37 (54%)
Linker 1 151..168 5/42 (12%)
Coil 1B 169..260 33/108 (31%)
Linker 12 261..283 6/28 (21%)
Coil 2 284..422 47/148 (32%)
Tail 423..472 10/34 (29%)
Interaction with Type I keratins and keratin filaments 425..472 9/32 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 426..472 9/31 (29%)
LamNP_476616.1 Filament 54..409 CDD:459643 114/374 (30%)
LTD 467..572 CDD:460003
Blue background indicates that the domain is not in the aligned region.

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