Protein Alignment KRT14 and CG31533

DIOPT Version :10

• Sequence 1: NP_000517.3
• Gene: KRT14 / 3861
• HGNCID: 6416
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_731887.1
• Gene: CG31533 / 318788
• FlyBaseID: FBgn0051533
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 273
• Identity: 57/273 - (20%)
• Similarity: 102/273 - (37%)
• Gaps: 72/273 - (26%)

Human   176 ILTATVDNANVLL----------QIDNARLAADDFRTKYETEL-----NLRMSVEADINGLRRVL 225
            |...|:|....||          ::.::|:..|.|....|.||     .||.|:|.....|..|.
  Fly    18 IFGVTIDEPAKLLVETKVAGKSVKVTSSRINVDQFVAGREFELPMEASTLRQSLEEKGLTLAGVY 82

Human   226 DELTLARADLEMQIESLKEELAYLKKN--HEEEMNALRG-QVGGDVNVEMDAAPGVDLSRILNEM 287
            ...||.:|.....:|.| ::::....:  ||:.::.:|. .|.|.|:|         |.|:..:.
  Fly    83 QGSTLGKATGNFPVEFL-DKISPTMNDLVHEDTLDLVRRVDVVGTVSV---------LIRLTVKC 137

Human   288 RDQYEKMAEK---NRKDAEEWFFTKTEELNREVATNSE------------------LVQSGKSEI 331
            .:..|:...:   :|.........|.|:..| |:..|:                  |::......
  Fly   138 EEHPEQKPSRQSLSRTSKSSMILPKKEKSGR-VSCASQGPTFNPQDVMFLIGDPDPLLRIPSEPC 201

Human   332 SELRRTM--QNLEIELQSQLSMKASLENSLEETKGRY-----C-------MQLAQIQEMIGSVEE 382
            |||...:  :.|:::||..        .|||..:..:     |       |||.::.|...::.:
  Fly   202 SELLSEIGDERLKLDLQRY--------KSLENRRAIFPDDDRCPKQKPSFMQLKKLTEEYSNIID 258

Human   383 QLAQLRCEMEQQN 395
            .:.:...|||.|:
  Fly   259 SVTKKVKEMEPQS 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT14	NP_000517.3	Head	1..114
		Filament	114..425	CDD:459643	57/273 (21%)
		Coil 1A	115..150
		Linker 1	151..168
		Coil 1B	169..260		24/100 (24%)
		Linker 12	261..283		6/22 (27%)
		Coil 2	284..422		26/147 (18%)
		Tail	423..472
		Interaction with Type I keratins and keratin filaments	425..472
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..472
CG31533	NP_731887.1	DUF4788	12..260	CDD:406440	53/260 (20%)
		DUF4776	315..758	CDD:406413