Protein Alignment KRT14 and Krt14

DIOPT Version :10

• Sequence 1: NP_000517.3
• Gene: KRT14 / 3861
• HGNCID: 6416
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_001008751.1
• Gene: Krt14 / 287701
• RGDID: 1307463
• Length: 485
• Species: Rattus norvegicus
• Alignment Length: 496
• Identity: 428/496 - (86%)
• Similarity: 446/496 - (89%)
• Gaps: 35/496 - (7%)

Human     1 MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSSRFSSGGACGL 65
            |.||||||||||||||||    ||||||||:|||||||||||||||||     .|||||.||..:
  Rat     1 MATCSRQFTSSSSMKGSC----GIGGGSSRMSSVLAGGSCRAPSTYGG-----MSRFSSAGAYAV 56

Human    66 GGGYGGGFSSSSSSFGSGFGGGYGGGLGAGLGGGFGGGFAG------------------GDGLLV 112
            |.||||||  ||||||.|||||.|||:|.|||||.||||.|                  ||||||
  Rat    57 GSGYGGGF--SSSSFGGGFGGGIGGGIGGGLGGGIGGGFGGGIGGGFGGGIGSGFGGGLGDGLLV 119

Human   113 GSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTIEDLRNKIL 177
            |||||||||||||||:||||||||||||:|||||||||||||||.|||||||||||||||::|||
  Rat   120 GSEKVTMQNLNDRLATYLDKVRALEEANSDLEVKIRDWYQRQRPTEIKDYSPYFKTIEDLKSKIL 184

Human   178 TATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIESL 242
            .|||||||||||||||||||||||||:|||.:||::||:||||||||||||||||||||||||||
  Rat   185 AATVDNANVLLQIDNARLAADDFRTKFETEQSLRINVESDINGLRRVLDELTLARADLEMQIESL 249

Human   243 KEELAYLKKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFF 307
            |||||||||||||||.::|||||||||||||||||||||||||||||||||||||||||||:|||
  Rat   250 KEELAYLKKNHEEEMASMRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFF 314

Human   308 TKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENSLEETKGRYCMQLAQ 372
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
  Rat   315 TKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLAQ 379

Human   373 IQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHL------SSSQF 431
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||      |||||
  Rat   380 IQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSAQFSSSSQF 444

Human   432 SSGSQSSRDVTSSSRQIRTKVMDVHDGKVVSTHEQVLRTKN 472
            ||||||||||||::|||||||||||||||||||||||||||
  Rat   445 SSGSQSSRDVTSTNRQIRTKVMDVHDGKVVSTHEQVLRTKN 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT14	NP_000517.3	Head	1..114		87/130 (67%)
		Filament	114..425	CDD:459643	293/310 (95%)
		Coil 1A	115..150		32/34 (94%)
		Linker 1	151..168		15/16 (94%)
		Coil 1B	169..260		80/90 (89%)
		Linker 12	261..283		21/21 (100%)
		Coil 2	284..422		135/137 (99%)
		Tail	423..472		46/54 (85%)
		Interaction with Type I keratins and keratin filaments	425..472		44/52 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..472		43/51 (84%)
Krt14	NP_001008751.1	Head. /evidence=ECO:0000250|UniProtKB:P02533	1..121		87/130 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		18/23 (78%)
		Filament	121..432	CDD:459643	293/310 (95%)
		Coil 1A. /evidence=ECO:0000250|UniProtKB:P02533	122..157		32/34 (94%)
		Linker 1. /evidence=ECO:0000250|UniProtKB:P02533	158..175		15/16 (94%)
		Coil 1B. /evidence=ECO:0000250|UniProtKB:P02533	176..267		80/90 (89%)
		Linker 12. /evidence=ECO:0000250|UniProtKB:P02533	268..290		21/21 (100%)
		Coil 2. /evidence=ECO:0000250|UniProtKB:P02533	291..429		135/137 (99%)
		Tail. /evidence=ECO:0000250|UniProtKB:P02533	430..485		46/54 (85%)
		Interaction with Type I keratins and keratin filaments. /evidence=ECO:0000250	432..485		44/52 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	437..458		17/20 (85%)