Protein Alignment KRT14 and alp7

DIOPT Version :10

• Sequence 1: NP_000517.3
• Gene: KRT14 / 3861
• HGNCID: 6416
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_594820.1
• Gene: alp7 / 2543382
• PomBaseID: SPAC890.02C
• Length: 474
• Species: Schizosaccharomyces pombe
• Alignment Length: 294
• Identity: 62/294 - (21%)
• Similarity: 116/294 - (39%)
• Gaps: 58/294 - (19%)

Human   156 PAEIKDYSPYFKTIEDLRNKILTATVDNANVLLQ--IDNARLAADDFRTKYET------------ 206
            |..:||         ::||. .|.:...|::..|  |::.:..    :.|||.
pombe   193 PVHLKD---------NIRNS-ATPSTSQADIPTQYPINSTQKQ----QAKYEAEIEGYKAKLAGT 243

Human   207 --ELNLRMSVEADING-LRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGGDV 268
              |:::..:...:::| |..|.|:|...|:.......|.|:....|.:.|.||..||  |.|...
pombe   244 YHEISVLQNTIVNVSGQLIAVNDQLQQLRSGKASTSPSTKDTNMRLVEGHNEETLAL--QRGKYT 306

Human   269 NVEMDAAPGVDLSRILNEMRDQY-----EKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGK 328
            ..|:|......:.::..::..||     :|:.......|.::..| .:||..::.|.....:...
pombe   307 QEEVDKLIQERMEKVAEDLHAQYSAKHTQKINAFKANYARKYEAT-IQELQNQIGTAPNAPKISN 370

Human   329 SEISELRRTM----QNLEIELQSQLSMKASLENSLEETKG------RYCMQLAQIQEMIGSVEE- 382
            |...|.||.:    |.|:.:|:..:..:..:.:.|...|.      :..||  |..:..|.:|.
pombe   371 SNWEEERRALKADNQTLQKQLEKAIQERQDMSDFLNNFKADMAKSDKLLMQ--QQSQQTGDLETL 433

Human   383 --QL----AQLRCEMEQQNQEYKILLDVKTRLEQ 410
              ||    .:||.|.|::.|..::..|:...::|
pombe   434 RLQLQALQEELRVEREERQQLIQMSEDLVIAMDQ 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT14	NP_000517.3	Head	1..114
		Filament	114..425	CDD:459643	62/294 (21%)
		Coil 1A	115..150
		Linker 1	151..168		3/11 (27%)
		Coil 1B	169..260		22/107 (21%)
		Linker 12	261..283		4/21 (19%)
		Coil 2	284..422		31/149 (21%)
		Tail	423..472
		Interaction with Type I keratins and keratin filaments	425..472
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..472
alp7	NP_594820.1	SMC_prok_B	<229..>473	CDD:274008	52/244 (21%)
		Fungal_TACC	316..407	CDD:403801	16/91 (18%)