Protein Alignment KRT14 and ifc-2

DIOPT Version :10

• Sequence 1: NP_000517.3
• Gene: KRT14 / 3861
• HGNCID: 6416
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_001362085.1
• Gene: ifc-2 / 180414
• WormBaseID: WBGene00002056
• Length: 1339
• Species: Caenorhabditis elegans
• Alignment Length: 472
• Identity: 116/472 - (24%)
• Similarity: 175/472 - (37%)
• Gaps: 147/472 - (31%)

Human    81 GSGFGGGYGGGLGAGLGGGFGGGFAGGDGLLVGS------------------EKVTMQNLNDRLA 127
            |||....|..|.|..     .|.:|.|.|.||..                  ||..:..||||||
 Worm   721 GSGMSRTYSEGRGLA-----SGTYASGFGQLVSGMSSAGAICTTQIRDAREREKREIGLLNDRLA 780

Human   128 SYLDKVRALEEANA-----------------------DLEVK----IRDWYQRQRPAEIKDYSPY 165
            .|::|||.||..|.                       |.|:.    |.:.....|....:|.:..
 Worm   781 DYIEKVRFLEAQNRCLSHDIDILRNGFSGGGHVSGLFDAEINQAKHILEQTTAHRSTFERDITGL 845

Human   166 FKTIEDLRNKILTATVDNANVLL------QIDNARLAADDFRTKYETELNL-----RMSVEADIN 219
            ...||..|.|.|    |..|.:.      .:|..|||      |.|.|::|     |: ||.|:.
 Worm   846 SAEIEVFRKKWL----DAVNAVKAHREDHDVDLDRLA------KIEAEISLFKRKIRI-VEEDVI 899

Human   220 GLRRVLD---------------------ELTLARADLEMQIESLKEELAYLKKNH---EEEMNAL 260
            .:||..|                     |.:|..:||..:|..|:.|      |:   |:|:..:
 Worm   900 RIRRENDGIYNEIARIKQLTHNEIALKNERSLNVSDLLQRINLLQTE------NNVRIEQELVFI 958

Human   261 RGQVGGD----VNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNRE-VATN 320
            |.....|    ...|:.||        :.::|..||.::.:||:|.|.|:..:..::..| |..|
 Worm   959 RRDTTADNRDYFRHELQAA--------IRDIRADYEAISIRNRQDIEVWYREQIRKIQDESVRVN 1015

Human   321 SELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENSLEETKGR-----YCMQLAQIQEMIGSV 380
            .:|.   |.|:..:|.|:.|:...|.........||..:::.|..     :.:.||:....|.::
 Worm  1016 PDLY---KEELISIRTTVTNVRSRLAEVEGRNFFLERLIDDLKNNEEAKFFEISLAERDAQIATL 1077

Human   381 EEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEG-------EDAHLSSSQFSSG---- 434
            .:|..:|..:||:       |.|.:..|..||..||.||.|       .:.|.|.|..:.|
 Worm  1078 RDQCTELSIQMEK-------LCDNEISLRAEIERYRILLNGANVTTYTSNTHGSGSGIAVGGVVG 1135

Human   435 ------SQSSRDVTSSS 445
                  ||::|..:||:
 Worm  1136 GSTRVISQTTRTHSSSN 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT14	NP_000517.3	Head	1..114		12/32 (38%)
		Filament	114..425	CDD:459643	95/407 (23%)
		Coil 1A	115..150		18/61 (30%)
		Linker 1	151..168		2/16 (13%)
		Coil 1B	169..260		32/125 (26%)
		Linker 12	261..283		5/25 (20%)
		Coil 2	284..422		38/150 (25%)
		Tail	423..472		9/33 (27%)
		Interaction with Type I keratins and keratin filaments	425..472		9/31 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..472		8/30 (27%)
ifc-2	NP_001362085.1	Filament	768..1111	CDD:459643	94/377 (25%)