Protein Alignment KRT14 and Krt14

DIOPT Version :10

• Sequence 1: NP_000517.3
• Gene: KRT14 / 3861
• HGNCID: 6416
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_058654.1
• Gene: Krt14 / 16664
• MGIID: 96688
• Length: 484
• Species: Mus musculus
• Alignment Length: 489
• Identity: 435/489 - (88%)
• Similarity: 453/489 - (92%)
• Gaps: 22/489 - (4%)

Human     1 MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSSRFSSGGACGL 65
            |.||||||||||||||||    ||||||||:||:|||||||||||| ||:||:|||||||||||:
Mouse     1 MATCSRQFTSSSSMKGSC----GIGGGSSRMSSILAGGSCRAPSTY-GGMSVTSSRFSSGGACGI 60

Human    66 GGGYGGGFSSSS------SSFG---SGFGGGYGGGLGAGLGGGFGGGFAG--GDGLLVGSEKVTM 119
            ||||||.|||||      |.||   .|||||:|||||.|.|||.|||..|  |||||||||||||
Mouse    61 GGGYGGSFSSSSFGGGLGSGFGGRFDGFGGGFGGGLGGGFGGGLGGGLGGGIGDGLLVGSEKVTM 125

Human   120 QNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTIEDLRNKILTATVDNA 184
            ||||||||:||||||||||||.:||||||||||||||.|||||||||||||||::|||.||||||
Mouse   126 QNLNDRLATYLDKVRALEEANTELEVKIRDWYQRQRPTEIKDYSPYFKTIEDLKSKILAATVDNA 190

Human   185 NVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYL 249
            |||||||||||||||||||:|||.:||||||||||||||||||||||||||||||||||||||||
Mouse   191 NVLLQIDNARLAADDFRTKFETEQSLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYL 255

Human   250 KKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELN 314
            ||||||||.::|||||||||||||||||||||||||||||||||||||||||||||||:||||||
Mouse   256 KKNHEEEMASMRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFSKTEELN 320

Human   315 REVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENSLEETKGRYCMQLAQIQEMIGS 379
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
Mouse   321 REVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLAQIQEMIGS 385

Human   380 VEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHL------SSSQFSSGSQSS 438
            |||||||||||||||||||||||||||||||||||||||||||||||      ||||||||||||
Mouse   386 VEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSSSQFSSGSQSS 450

Human   439 RDVTSSSRQIRTKVMDVHDGKVVSTHEQVLRTKN 472
            |||||::|||||||||||||||||||||||||||
Mouse   451 RDVTSTNRQIRTKVMDVHDGKVVSTHEQVLRTKN 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT14	NP_000517.3	Head	1..114		92/123 (75%)
		Filament	114..425	CDD:459643	295/310 (95%)
		Coil 1A	115..150		31/34 (91%)
		Linker 1	151..168		15/16 (94%)
		Coil 1B	169..260		83/90 (92%)
		Linker 12	261..283		21/21 (100%)
		Coil 2	284..422		135/137 (99%)
		Tail	423..472		46/54 (85%)
		Interaction with Type I keratins and keratin filaments	425..472		44/52 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..472		43/51 (84%)
Krt14	NP_058654.1	Head	1..120		92/123 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		17/22 (77%)
		Filament	120..431	CDD:459643	295/310 (95%)
		Coil 1A	121..156		31/34 (91%)
		Linker 1	157..174		15/16 (94%)
		Coil 1B	175..266		83/90 (92%)
		Linker 12	267..289		21/21 (100%)
		Coil 2	290..428		135/137 (99%)
		Tail	429..484		46/54 (85%)
		Interaction with Type I keratins and keratin filaments. /evidence=ECO:0000250	431..484		44/52 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	435..457		17/21 (81%)