DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shep and Rbms3

DIOPT Version :9

Sequence 1:	NP_001246636.1	Gene:	shep / 38605	FlyBaseID:	FBgn0052423	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_017451688.2	Gene:	Rbms3 / 680726	RGDID:	1588240	Length:	536	Species:	Rattus norvegicus

Alignment Length:	636	Identity:	218/636 - (34%)
Similarity:	269/636 - (42%)	Gaps:	191/636 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GVSMRGPSNAQQLPPQIPRSQNYSNGSSSSAAAAPLTSRSAFPGAPLTASAVALKGALPQRPPAM 96
            |||.|        |..|||||     .:..|..||                       ||.|...
  Rat     7 GVSPR--------PEPIPRSQ-----GAGGACQAP-----------------------PQPPQPQ 35

  Fly    97 TSPAAAAAGAAL---AAGAPYRGAASWTPQGYAPAAAAAAAAVAQQAAYRYTAPLP--------- 149
            ..|....|...:   :|||.........|.|....:.:.|...|.|::.......|
  Rat    36 PQPQQQLAQDEVPSESAGAEDSDDPEARPNGERGESKSNATVRAYQSSKSRVTMSPGFSSQWSNS 100

  Fly   150 QPAYAAYT---------PHTATTPATTTVSFLSQPVDYYWYGQRVPTAASPSNTNSSSSSNTGSQ 205
            |||:..|:         .|.:.|..|      ..||..|..........||| |||||:|:
  Rat   101 QPAWNTYSFPRASLHYQSHASYTYCT------GHPVQSYAPAPHPMAPPSPS-TNSSSNSS---- 154

  Fly   206 SGTLSTSLSNTTNTNTNMGPNGTVQNQNQQGGEQLSKTNLYIRGLQQGTTDKDLVNMCAQYGTII 270
                                           ||||||||||||||..||||:||:.:|..||.|:
  Rat   155 -------------------------------GEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIV 188

  Fly   271 STKAILDKTTNKCKGYGFVDFEQPAFAECAVKGLQGKGVQAQMAKQQEQDPTNLYIANLPPHFKE 335
            ||||||||.||:|||||||||:.||.|:.||..|:..|||||||||||||||||||:|||....|
  Rat   189 STKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDE 253

  Fly   336 TDLEAMLSKYGQVVSTRILRDQQMNSKGVGFARMESREKCEQIIQMFNGN------TIPGAKDPL 394
            .:||.||..:|.|:|||||||....|:|||||||||.||||.:||.|||.      .||...:||
  Rat   254 QELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPL 318

  Fly   395 LVKFADGGPKKKNLFKTPDPNARAWRDVSAEGIPVAYDPTMQ-QNGVSVNVGTPIGVPYSRFSAP 458
            |.||||||.||:........|.|.|......|:.:.||||.. |||.              :|:|
  Rat   319 LCKFADGGQKKRQSQNKHTQNGRPWPREGEAGMALTYDPTAALQNGF--------------YSSP 369

  Fly   459 QVGGYPVAGSQWIPGYMMTQVDDQTSYSPQYMQMAAAPPLGV-----TSYKPEAVNQVQPRGISM 518
                |.:|.::.||         |||.:|    ..||.|:..     ||:.|.....:||.|..:
  Rat   370 ----YSLATNRMIP---------QTSITP----FIAASPVSTYQVQSTSWTPHLPYIMQPTGAVI 417

  Fly   519 MVSGD-------TGVPYGTMMPQLATLQIGNS------------------YISP-----TY-PYY 552
            ..:.|       |.: .|.:..|:..|.:|.:                  |::.     || |.|
  Rat   418 TPTMDHPMSMQPTNI-VGPLTQQMNHLSLGTAGTIQSQDRIMVLHQLLCQYMTAAPMQGTYIPQY 481

  Fly   553 AP-PPT-------IIPTMPMT------DS---EQASTAASPDEAYTQYPHQ 586
            .| |||       :..|.|.|      ||   :|.....:|.|....|..|
  Rat   482 TPVPPTAVSIEGVVADTSPQTVAPSSQDSSGQQQQLAVDTPSEHAPAYSFQ 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shep	NP_001246636.1	RRM1_MSSP	243..313	CDD:240689	47/69 (68%)
shep	NP_001246636.1	RRM2_MSSP	322..400	CDD:240690	48/83 (58%)
Rbms3	XP_017451688.2	RRM_SF	156..239	CDD:418427	60/82 (73%)
Rbms3	XP_017451688.2	RRM2_RBMS3	239..326	CDD:240919	51/86 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	93	1.000	Domainoid score	I7357
eggNOG	1	0.900	-	-		E1_KOG4733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I2993
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001320
OrthoInspector	1	1.000	-	-		otm46039
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X530
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.920