Protein Alignment shep and RBMS1

DIOPT Version :10

• Sequence 1: NP_001246636.1
• Gene: shep / 38605
• FlyBaseID: FBgn0052423
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: XP_047301324.1
• Gene: RBMS1 / 5937
• HGNCID: 9907
• Length: 422
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 192/503 - (38%)
• Similarity: 241/503 - (47%)
• Gaps: 121/503 - (24%)

  Fly   120 WTPQGYAPAAAAAAAAVAQQAAYRYTAPLPQPAYAAYTPHTATTPATTTVSFLSQPVDYYWYGQR 184
            |..|.|           .|.|.|.|...| |...:....|....|:.:|.|
Human     5 WKQQMY-----------PQYATYYYPQYL-QAKQSLVPAHPMAPPSPSTTS-------------- 43

  Fly   185 VPTAASPSNTNSSSSSNTGSQSGTLSTSLSNTTNTNTNMGPNGTVQNQNQQGGEQLSKTNLYIRG 249
                   ||.|||||||:                                 |.:|||||||||||
Human    44 -------SNNNSSSSSNS---------------------------------GWDQLSKTNLYIRG 68

  Fly   250 LQQGTTDKDLVNMCAQYGTIISTKAILDKTTNKCKGYGFVDFEQPAFAECAVKGLQGKGVQAQMA 314
            |...|||:|||.:|..||.|:|||||||||||||||||||||:.||.|:.||..|:..|||||||
Human    69 LPPHTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMA 133

  Fly   315 KQQEQDPTNLYIANLPPHFKETDLEAMLSKYGQVVSTRILRDQQMNSKGVGFARMESREKCEQII 379
            ||||||||||||:|||....|.:||.||..:|||:|||||||....|:|||||||||.||||.:|
Human   134 KQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVI 198

  Fly   380 QMFNG---NTIPGAK---DPLLVKFADGGPKKKNLFKTPD---PNARAWR---DVSAEGIPVAYD 432
            ..|||   .|.||..   :|||.||||||.||:   :.|:   ||.|.|.   :|...|:.:.||
Human   199 GHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKR---QNPNKYIPNGRPWHREGEVRLAGMTLTYD 260

  Fly   433 PTMQ--QNGVSVNVGTPIGVPYSR---------FSAPQVGGYPVAGSQWIPGYMMTQVDDQTSYS 486
            ||..  |||.   ..:|..:..:|         :.|..|..|.||.......|..:.:..|   |
Human   261 PTTAAIQNGF---YPSPYSIATNRMITQTSITPYIASPVSAYQVAKETRENKYRGSAIKVQ---S 319

  Fly   487 PQYMQ----------MAAAPPLGVT-SYKPEAVNQVQPRGISMMVSGDTGVPYGTMMPQLATLQI 540
            |.:||          ....|.:..| |.:|.::.....:.:|.:..|.|    ||.||..:.:|
Human   320 PSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGST----GTYMPATSAMQ- 379

  Fly   541 GNSYISPTYPYYA-PPPTIIPTMPMTDSEQASTAASPDEA-YTQYPHQ 586
             .:|:    |.|| ...|.:|....:..:|.:...|.|.: ||..|::
Human   380 -GAYL----PQYAHMQTTAVPVEEASGQQQVAVETSNDHSPYTFQPNK 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shep	NP_001246636.1	RRM_SF	240..321	CDD:473069	60/80 (75%)
		RRM2_MSSP	322..400	CDD:409690	49/83 (59%)
RBMS1	XP_047301324.1	RRM1_MSSP1	55..140	CDD:409900	62/84 (74%)
		RRM2_MSSP1	141..225	CDD:409903	49/83 (59%)