DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shep and Rbms1

DIOPT Version :9

Sequence 1:	NP_001246636.1	Gene:	shep / 38605	FlyBaseID:	FBgn0052423	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_006234296.1	Gene:	Rbms1 / 362138	RGDID:	1307777	Length:	421	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	181/472 - (38%)
Similarity:	230/472 - (48%)	Gaps:	108/472 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 LPQPAYAAYTPHTATTPATTTVSFLSQPVDYYWYGQRVPTAASPSNTNSSSSSNTGSQSGTLSTS 212
            |||.:.....|....:|:||:                       ||.|||||||:
  Rat    25 LPQQSLVPAHPMAPPSPSTTS-----------------------SNNNSSSSSNS---------- 56

  Fly   213 LSNTTNTNTNMGPNGTVQNQNQQGGEQLSKTNLYIRGLQQGTTDKDLVNMCAQYGTIISTKAILD 277
                                   |.:||||||||||||...|||:|||.:|..||.|:|||||||
  Rat    57 -----------------------GWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILD 98

  Fly   278 KTTNKCKGYGFVDFEQPAFAECAVKGLQGKGVQAQMAKQQEQDPTNLYIANLPPHFKETDLEAML 342
            |.||||||||||||:.||.|:.||..|:..|||||||||||||||||||:|||....|.:||.||
  Rat    99 KATNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENML 163

  Fly   343 SKYGQVVSTRILRDQQMNSKGVGFARMESREKCEQIIQMFNG---NTIPGAK---DPLLVKFADG 401
            ..:|||:|||:|||....|:|||||||||.||||.:|..|||   .|.||..   :|||.|||||
  Rat   164 KPFGQVISTRVLRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADG 228

  Fly   402 GPKKKNLFKTPD---PNARAWRDVSAEGIPVAYDPTMQ--QNGVSVNVGTPIGVPYSR------- 454
            |.||:   :.|:   ||.|.|......|:.:.||||..  .||.   ..:|..:..:|
  Rat   229 GQKKR---QNPNKYIPNGRPWPREGEAGMTLTYDPTTAALHNGF---YPSPYSIATNRMITQTSL 287

  Fly   455 --FSAPQVGGYPVAGSQWIPGYMMTQVDDQTSYSPQYMQ----------MAAAPPLGVT-SYKPE 506
              :.|..|..|.||.......|....:..|   ||.:||          ....|.:..| |.:|.
  Rat   288 TPYIASPVSAYQVAKETREKKYRGPALKVQ---SPSWMQPQPYILQHPGAVLTPSMEHTMSLQPA 349

  Fly   507 AVNQVQPRGISMMVSGDTGVPYGTMMPQLATLQIGNSYISPTYPYYAPPPT-IIPTMPMTDSEQA 570
            ::.....:.:|.:..|.|    ||.||..:.:|  .:|:    |.|....| .:|....:..:|.
  Rat   350 SMISPLAQQMSHLSLGST----GTYMPATSAMQ--GAYL----PQYTHMQTATVPVEEASGQQQV 404

  Fly   571 STAASPDEA-YTQYPHQ 586
            :...|.|.: ||..|::
  Rat   405 TVETSNDHSPYTFPPNK 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shep	NP_001246636.1	RRM1_MSSP	243..313	CDD:240689	48/69 (70%)
shep	NP_001246636.1	RRM2_MSSP	322..400	CDD:240690	48/83 (58%)
Rbms1	XP_006234296.1	RRM1_MSSP1	57..142	CDD:240914	61/84 (73%)
Rbms1	XP_006234296.1	RRM2_MSSP2	143..228	CDD:240918	49/84 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	93	1.000	Domainoid score	I7357
eggNOG	1	0.900	-	-		E1_KOG4733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I2993
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001320
OrthoInspector	1	1.000	-	-		otm46039
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X530
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.960