DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shep and spo5

DIOPT Version :9

Sequence 1:	NP_001246636.1	Gene:	shep / 38605	FlyBaseID:	FBgn0052423	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_596047.1	Gene:	spo5 / 2540637	PomBaseID:	SPBC29A10.02	Length:	567	Species:	Schizosaccharomyces pombe

Alignment Length:	633	Identity:	166/633 - (26%)
Similarity:	256/633 - (40%)	Gaps:	166/633 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SPAPPPQQQQQMGGPPHQ--------QQGGGGGGGVSMRGPSNAQQLPP--------QIPRSQNY 54
            ||:..|....::..|..|        ::..|....:.:..|..:....|        :.|.|..
pombe    16 SPSRDPLSTTELSTPTSQTTVDVNDTKKSEGLDSTIILLTPGTSPNATPGSSELGLSKKPNSIK- 79

  Fly    55 SNGSSSSAAAAPLTSRSAFPGAPLTASAVAL------KGALPQRPPAMTS---PAAAAAGAALAA 110
            :|..|::|.||.|..|:|.....:|...::.      .|.|||:.....:   |:..|...|::.
pombe    80 NNTYSTAAQAAYLNRRAADQSTVMTTDPISYANNNINNGTLPQQNAYYANSYYPSYYAQSQAISN 144

  Fly   111 GAPYRGAASWTPQGYAPAAAAAAAAVAQQ-------------AAYRYTAPLPQPAYAAYTPHTAT 162
            ..|  |.:     |:.||..:.|.....|             ..::|..|..|..|    |...:
pombe   145 NRP--GVS-----GFRPAFNSVAPCYGSQWQTHQSVHPYHVNNTHQYLKPYVQNVY----PQMPS 198

  Fly   163 TPATTTVSFLSQP----VDYYWYGQRVPTAASPSNTNSSS--SSNTGSQS--GTLSTSLS-NTTN 218
                     |:||    |:...|...||:|..|:|:.|.|  |.:.|.::  ..::..:| .||.
pombe   199 ---------LNQPGLHIVNQPTYLAPVPSATVPTNSVSLSMPSFSQGQKNIPAAINQEMSVGTTK 254

  Fly   219 TNTN------------------MGPNGTVQNQNQQGG-EQLSKT-NLYIRGLQQGTTDKDLVNMC 263
            .|||                  |.|   :.:.|::.. |..|:| |:|||||...|:|::|:...
pombe   255 ENTNYLSQLVGLHPAIPPAIPSMFP---MSHDNKKSNMESTSRTRNVYIRGLPPNTSDENLLLYT 316

  Fly   264 AQYGTIISTKAILDKTTNKCKGYGFVDFEQPAFAECAVKGLQGKGVQAQMAKQ---------QEQ 319
            .::|.:.|:|||:|..||.||||||..||:...|...:..:...|.|...||:         |:.
pombe   317 NRFGKVSSSKAIIDMETNLCKGYGFACFEEEKSALICISAMTLCGYQCSFAKESFSARLQSLQDT 381

  Fly   320 DPTNLYIANLPPHFKETDLEAMLSKYGQVVSTRILRDQQMNSKGVGFARMESREKCEQIIQMFNG 384
            :.|||||:|||.|:.|:|: :.|.|..:::|.|:|||.:..|:|||||||:.|:..|.||..||.
pombe   382 ESTNLYISNLPLHWNESDI-STLFKPSKIISNRVLRDSKEQSRGVGFARMQDRKTAEDIINKFNN 445

  Fly   385 NTIPGAKDPLLVKFADGGPKKKNLFKTPDPNARAWRDVSAEGIPVAYDPTMQQNGVSVNVGTPIG 449
            ..:..|..||.::|||...:||  ||......|.||         |.:.::...|::.|......
pombe   446 FVLDPALPPLQIRFADSTDQKK--FKGQTQKRRLWR---------AREYSVLTKGMTANNAFSKV 499

  Fly   450 VPYSRFSAP-QVGGYPVAGSQWIPGYMMTQVDDQTSY--SPQYMQMAAAPPLGVTSYKPEAVNQV 511
            ..::..|.| :||.|       :|      ::..|.|  ||.|
pombe   500 EEFANNSMPSKVGMY-------VP------LESNTVYQHSPTY---------------------- 529

  Fly   512 QPRGISMMVSGDTGVPYG--TMMPQLATLQIGNSYISPTYPYYAPPPT 557
                       ||   ||  :|.|..:...........|.||:|.|.|
pombe   530 -----------DT---YGWQSMYPSYSVYPSNYENSRSTTPYHAHPAT 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shep	NP_001246636.1	RRM1_MSSP	243..313	CDD:240689	29/70 (41%)
shep	NP_001246636.1	RRM2_MSSP	322..400	CDD:240690	36/77 (47%)
spo5	NP_596047.1	RRM1_MSSP	296..366	CDD:240689	28/69 (41%)
spo5	NP_596047.1	RRM2_MSSP	384..461	CDD:240690	36/77 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	63	1.000	Domainoid score	I2931
eggNOG	1	0.900	-	-		E1_KOG4733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	145	1.000	Inparanoid score	I1333
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001320
OrthoInspector	1	1.000	-	-		oto101800
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3067
SonicParanoid	1	1.000	-	-		X530
TreeFam	1	0.960	-	-
	9	9.040