DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4611 and Ptcd1

DIOPT Version :9

Sequence 1:	NP_647949.1	Gene:	CG4611 / 38601	FlyBaseID:	FBgn0035591	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	NP_598496.3	Gene:	Ptcd1 / 71799	MGIID:	1919049	Length:	695	Species:	Mus musculus

Alignment Length:	653	Identity:	198/653 - (30%)
Similarity:	307/653 - (47%)	Gaps:	107/653 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ELITAAPKEHQ----------KFKPEKKPKEKSTKKVQDFGDPDTFGDAKVAATEDPGDVEEEEF 134
            :|.|.||:|..          ||. .::...|||.::.:           :...|..|   |||.
Mouse    72 KLSTVAPQEEAEEESFGSLSGKFS-SRRIFHKSTAQLYN-----------LQLKEQGG---EEEE 121

  Fly   135 LSNSTRRSKKLKAVEYARQIKDHLKANRLNEAIAVLEQRMLKEDRAKPDKYIYNLLISGCAKAGY 199
            |.....|.::.....|..|.|..:|..:|.||:.:.|::||||:|.:|.:..|.:||.||.:.||
Mouse   122 LEPRPWRGRRNTQYWYFFQCKRLIKEGKLAEALDLFERQMLKEERLQPLECNYTVLIGGCGRVGY 186

  Fly   200 TRKAFFLYTKMRQRGLQVTGGTYTSLFNACANAPSVSDGLAKAQILRENMLEKGYEPNVKNYNAM 264
            .:|||.|:..|::|.|:.:..|||:|||.||.:|.....|..|..||:.:..:.::.|:|.|:|:
Mouse   187 LKKAFRLFNDMKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQARNFQLNLKTYHAL 251

  Fly   265 IKAYGRCGDVDTAYMLADEMMERQLELNADTFNFLLQACASNSEHGFRHALLTWHNMLQRGISPD 329
            :|...:|.|:.....:..|:::|...:..:||.|||..|..:.:.|||.|:..|..||..||.|.
Mouse   252 LKVAAKCADLRLCLDVFKEIIQRGHAVTEETFCFLLVGCIQDKKTGFRQAMQVWRQMLSLGIKPS 316

  Fly   330 YYSFNAMLRCARDCGFGD--------LDSMREVIDKIAPS----AARK---KPV----------- 368
            .:.:|.:|..|||||.||        |.|..|.|....|.    |.||   |.|
Mouse   317 RHGYNLLLEAARDCGLGDPEVASRLLLTSQEETILLPPPKGRHMAGRKVQAKTVHGVSLRHVEAL 381

  Fly   369 ---LQLEKGQQDD----LPSVEANTTTLPAQIEVATTA---------------SELELPNLLLPQ 411
               |.||..|:.:    ||.....:.|.|   ||.|||               :.|||...||
Mouse   382 ERQLFLEPSQKLEGPPALPEARVTSRTQP---EVETTAEPGHTVALTPLASKPTHLELEVSLL-- 441

  Fly   412 PHLGSL----VALEEVTRPHERFLLLGGLTGFLEHMKQHNITPDIETFTAMLEVIPPTNAAEKQL 472
             .||:|    |:...|..|.:|..|:|||.|||..|.:|.:.|||:|.|.:.||:.|.:.||..|
Mouse   442 -SLGTLSPAVVSFGTVATPADRLALMGGLEGFLGKMTEHGLQPDIKTLTLLAEVVEPGSTAESSL 505

  Fly   473 LTFVRKIGLKADIDFFNILIKKRSMRFDYESAKEVLLMIRTAGLRPDIVTYGVLALGCRTQEEAR 537
            |:.:.:..::||:.|||.||:|:|...|.|.||.:|.::...|:.|::.|:..||:||....:..
Mouse   506 LSVLDRHRVEADVTFFNTLIRKKSKLGDLEGAKALLPILAKKGIVPNLRTFCNLAIGCHRPRDGM 570

  Fly   538 ELLEQMHVAGIKMNMPILGAMLRQGCANKSFSYVNEIIQLSLEEGLKPNEAFLRHLHNFHRGCAR 602
            :||..|..:.:..|:.|...::........::|:..|::...:..:..||..:|.|.
Mouse   571 QLLADMKKSQVSPNIHIYSTLINAALKKLDYTYLISILKDMRQNSVPVNEVVVRQLE-------- 627

  Fly   603 AIDARHPSTKTAAFK--KGHSKFCDK---YRLYYEEQGLSGLKLEDAIAKVKERPYDQFKLPPVN 662
             ..|.:|.|    |.  ||.:.:.:|   :|.|| :|.|..:..|:|     ..|:.:|:..||.
Mouse   628 -FAAEYPPT----FDRYKGKNTYLEKIDGFRAYY-KQWLKAMPAEEA-----PHPWQEFQNKPVG 681

  Fly   663 GME 665
            ..:
Mouse   682 DQD 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4611	NP_647949.1	PPR_2	<157..196	CDD:289786	16/38 (42%)
		PPR_2	182..231	CDD:289786	22/48 (46%)
		PPR	185..215	CDD:279828	13/29 (45%)
		PPR repeat	186..213	CDD:276811	12/26 (46%)
		PPR repeat	219..252	CDD:276811	13/32 (41%)
		PPR_1	252..284	CDD:289614	7/31 (23%)
		PPR_2	256..304	CDD:289786	14/47 (30%)
		PPR repeat	258..287	CDD:276811	7/28 (25%)
		PPR repeat	293..324	CDD:276811	13/30 (43%)
		PPR repeat	330..357	CDD:276811	13/34 (38%)
		PPR repeat	485..514	CDD:276811	12/28 (43%)
		PPR repeat	552..576	CDD:276811	3/23 (13%)
Ptcd1	NP_598496.3	PPR 1	133..169		13/35 (37%)
		PPR 2	170..204		14/33 (42%)
		PPR_2	174..217	CDD:289786	20/42 (48%)
		PPR	174..206	CDD:273253	14/31 (45%)
		PPR repeat	174..200	CDD:276811	12/25 (48%)
		PPR 3	205..243		13/37 (35%)
		PPR repeat	206..239	CDD:276811	13/32 (41%)
		PPR 4	244..278		9/33 (27%)
		PPR repeat	245..274	CDD:276811	7/28 (25%)
		PPR 5	279..315		15/35 (43%)
		PPR repeat	280..311	CDD:276811	13/30 (43%)
		PPR 6	316..352		13/35 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..416		8/27 (30%)
		PPR 5	470..485		6/14 (43%)
		PPR 7	517..551		14/33 (42%)
		PPR repeat	521..547	CDD:276811	11/25 (44%)
		PPR_2	551..594	CDD:289786	11/42 (26%)
		PPR 8	552..583		8/30 (27%)
		PPR repeat	553..579	CDD:276811	8/25 (32%)
		PPR 9	584..618		4/33 (12%)
		PPR repeat	585..614	CDD:276811	3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..695		3/13 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5548
eggNOG	1	0.900	-	-		E33208_3BFSV
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33161
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3109
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54853
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007295
OrthoInspector	1	1.000	-	-		oto92128
orthoMCL	1	0.900	-	-		OOG6_106729
Panther	1	1.100	-	-	LDO	PTHR24014
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5607
SonicParanoid	1	1.000	-	-		X5397
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.860